Lyonpo Khandu Wangchuk (born 24 November 1950) is a political figure in Bhutan. He was Chairman of the Council (Prime Minister) from 2001 until 2002. In September 2006, he became Prime Minister again; he was then replaced by Kinzang Dorji on 2 August 2007, after Wangchuk resigned to participate in the 2008 election as a member of the Druk Phuensum Tshogpa (DPT) political party. He also served as Minister of Foreign Affairs from 2003 to 2007.
Following the DPT's victory in the March 2008 election, Wangchuk became Minister of Economic Affairs on April 11, 2008.