L-seryl-tRNASec selenium transferase

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L-seryl-tRNASec selenium transferase
Identifiers
EC number 2.9.1.1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a L-seryl-tRNASec selenium transferase (EC 2.9.1.1) is an enzyme that catalyzes the chemical reaction

L-seryl-tRNASec + selenophosphate \rightleftharpoons L-selenocysteinyl-tRNASec + phosphate

Thus, the two substrates of this enzyme are L-seryl-tRNASec and selenophosphate, whereas its two products are L-selenocysteinyl-tRNASec and phosphate.

This enzyme belongs to the family of transferases, specifically those transferring selenium-containing groups selenotransferases. The systematic name of this enzyme class is selenophosphate:L-seryl-tRNASec selenium transferase. Other names in common use include L-selenocysteinyl-tRNASel synthase, L-selenocysteinyl-tRNASec synthase selenocysteine synthase, cysteinyl-tRNASec-selenium transferase, and cysteinyl-tRNASec-selenium transferase. This enzyme participates in selenoamino acid metabolism. It employs one cofactor, pyridoxal phosphate.

References[edit]

  • Forchhammer K, Bock A (1991). "Selenocysteine synthase from Escherichia coli. Analysis of the reaction sequence". J. Biol. Chem. 266 (10): 6324–8. PMID 2007585.