Hydrolase
From Wikipedia, the free encyclopedia
In biochemistry, a hydrolase (pronounced /ˈhaɪdrəleɪz/) is an enzyme that catalyzes the hydrolysis of a chemical bond. For example, an enzyme that catalyzed the following reaction is a hydrolase:
- A–B + H2O → A–OH + B–H
[edit] Nomenclature
Systematic names of hydrolases are formed as "substrate hydrolase." However, common names are typically in the form "substratease." For example, a nuclease is a hydrolase that cleaves nucleic acids.
[edit] Classification
Hydrolases are classified as EC 3 in the EC number classification of enzymes. Hydrolases can be further classified into several subclasses, based upon the bonds they act upon:
[edit] References
[edit] See also
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| 3.1.1: Carboxylic ester hydrolases |
Cholinesterase (Acetylcholinesterase, Butyrylcholinesterase) · Pectinesterase · 6-phosphogluconolactonase · PAF acetylhydrolase
Lipase (Bile salt-dependent, Gastric/Lingual, Pancreatic, Lysosomal, Hormone-sensitive, Endothelial, Hepatic, Lipoprotein, Monoacylglycerol, Diacylglycerol)
Phospholipase ( A1, A2, B)
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| 3.1.2: Thioesterase |
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| 3.1.3: Phosphatase |
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| 3.1.4: Phosphodiesterase |
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| 3.1.6: Sulfatase |
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Nuclease (includes
deoxyribonuclease and
ribonuclease) |
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| 3.6.1 |
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| 3.6.2 |
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| 3.6.3-4: ATPase |
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| 3.6.5: GTPase |
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Rho family of GTPases: Cdc42 (CDC42, TC10, TCL) • RhoUV (RhoU, RhoV) • Rac (Rac1, 2, 3, RhoG) • RhoBTB (1, 2) • RhoH • Rho (A, B, C) • Rnd (1, 2, 3) • RhoDF (RhoF, RhoD)
other: Ras ( HRAS, KRAS, NRAS) · Rab ( RAB23, RAB27) · Arf ( ARF6, SAR1B, ARL13B, ARL6) · Ran · Rheb · Rap
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Hydrolases: carbon-carbon ( EC 3.7)
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| 3.7.1 |
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