LIMK1

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LIM domain kinase 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols LIMK1 ; LIMK; LIMK-1
External IDs OMIM601329 MGI104572 HomoloGene1738 ChEMBL: 3836 GeneCards: LIMK1 Gene
EC number 2.7.11.1
RNA expression pattern
PBB GE LIMK1 208372 s at tn.png
PBB GE LIMK1 204357 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3984 16885
Ensembl ENSG00000106683 ENSMUSG00000029674
UniProt P53667 P53668
RefSeq (mRNA) NM_001204426 NM_010717
RefSeq (protein) NP_001191355 NP_034847
Location (UCSC) Chr 7:
73.5 – 73.54 Mb
Chr 5:
134.66 – 134.69 Mb
PubMed search [1] [2]

LIM domain kinase 1 is an enzyme that in humans is encoded by the LIMK1 gene.[1][2]

Function[edit]

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs, a central PDZ domain, and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development.[3]

Clinical signficance[edit]

LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome.[3]

Interactions[edit]

LIMK1 has been shown to interact with:

References[edit]

  1. ^ Tassabehji M, Metcalfe K, Fergusson WD, Carette MJ, Dore JK, Donnai D, Read AP, Proschel C, Gutowski NJ, Mao X, Sheer D (Aug 1996). "LIM-kinase deleted in Williams syndrome". Nat Genet 13 (3): 272–3. doi:10.1038/ng0796-272. PMID 8673124. 
  2. ^ Osborne LR, Martindale D, Scherer SW, Shi XM, Huizenga J, Heng HH, Costa T, Pober B, Lew L, Brinkman J, Rommens J, Koop B, Tsui LC (Jan 1997). "Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients". Genomics 36 (2): 328–36. doi:10.1006/geno.1996.0469. PMID 8812460. 
  3. ^ a b "Entrez Gene: LIMK1 LIM domain kinase 1". 
  4. ^ Foletta VC, Lim MA, Soosairajah J, Kelly AP, Stanley EG, Shannon M, He W, Das S, Massague J, Bernard O, Soosairaiah J (September 2003). "Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1". J. Cell Biol. 162 (6): 1089–98. doi:10.1083/jcb.200212060. PMC 2172847. PMID 12963706. 
  5. ^ Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, Obinata T, Ohashi K, Mizuno K, Narumiya S (August 1999). "Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase". Science 285 (5429): 895–8. doi:10.1126/science.285.5429.895. PMID 10436159. 
  6. ^ Yokoo T, Toyoshima H, Miura M, Wang Y, Iida KT, Suzuki H, Sone H, Shimano H, Gotoda T, Nishimori S, Tanaka K, Yamada N (December 2003). "p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus". J. Biol. Chem. 278 (52): 52919–23. doi:10.1074/jbc.M309334200. PMID 14530263. 
  7. ^ Wang JY, Frenzel KE, Wen D, Falls DL (August 1998). "Transmembrane neuregulins interact with LIM kinase 1, a cytoplasmic protein kinase implicated in development of visuospatial cognition". J. Biol. Chem. 273 (32): 20525–34. doi:10.1074/jbc.273.32.20525. PMID 9685409. 
  8. ^ Edwards DC, Sanders LC, Bokoch GM, Gill GN (September 1999). "Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics". Nat. Cell Biol. 1 (5): 253–9. doi:10.1038/12963. PMID 10559936. 
  9. ^ Dan C, Kelly A, Bernard O, Minden A (August 2001). "Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin". J. Biol. Chem. 276 (34): 32115–21. doi:10.1074/jbc.M100871200. PMID 11413130. 
  10. ^ Birkenfeld J, Betz H, Roth D (January 2003). "Identification of cofilin and LIM-domain-containing protein kinase 1 as novel interaction partners of 14-3-3 zeta". Biochem. J. 369 (Pt 1): 45–54. doi:10.1042/BJ20021152. PMC 1223062. PMID 12323073. 

Further reading[edit]

  • Scott RW, Olson MF (2007). "LIM kinases: function, regulation and association with human disease.". J. Mol. Med. 85 (6): 555–68. doi:10.1007/s00109-007-0165-6. PMID 17294230. 
  • Mizuno K, Okano I, Ohashi K, et al. (1994). "Identification of a human cDNA encoding a novel protein kinase with two repeats of the LIM/double zinc finger motif.". Oncogene 9 (6): 1605–12. PMID 8183554. 
  • Okano I, Hiraoka J, Otera H, et al. (1996). "Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs.". J. Biol. Chem. 270 (52): 31321–30. doi:10.1074/jbc.270.52.31321. PMID 8537403. 
  • Frangiskakis JM, Ewart AK, Morris CA, et al. (1996). "LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition.". Cell 86 (1): 59–69. doi:10.1016/S0092-8674(00)80077-X. PMID 8689688. 
  • Nebl G, Meuer SC, Samstag Y (1996). "Dephosphorylation of serine 3 regulates nuclear translocation of cofilin.". J. Biol. Chem. 271 (42): 26276–80. doi:10.1074/jbc.271.42.26276. PMID 8824278. 
  • Hiraoka J, Okano I, Higuchi O, et al. (1997). "Self-association of LIM-kinase 1 mediated by the interaction between an N-terminal LIM domain and a C-terminal kinase domain.". FEBS Lett. 399 (1-2): 117–21. doi:10.1016/S0014-5793(96)01303-8. PMID 8980133. 
  • Yang N, Higuchi O, Ohashi K, et al. (1998). "Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization.". Nature 393 (6687): 809–12. doi:10.1038/31735. PMID 9655398. 
  • Wang JY, Frenzel KE, Wen D, Falls DL (1998). "Transmembrane neuregulins interact with LIM kinase 1, a cytoplasmic protein kinase implicated in development of visuospatial cognition.". J. Biol. Chem. 273 (32): 20525–34. doi:10.1074/jbc.273.32.20525. PMID 9685409. 
  • Edwards DC, Gill GN (1999). "Structural features of LIM kinase that control effects on the actin cytoskeleton.". J. Biol. Chem. 274 (16): 11352–61. doi:10.1074/jbc.274.16.11352. PMID 10196227. 
  • Sotiropoulos A, Gineitis D, Copeland J, Treisman R (1999). "Signal-regulated activation of serum response factor is mediated by changes in actin dynamics.". Cell 98 (2): 159–69. doi:10.1016/S0092-8674(00)81011-9. PMID 10428028. 
  • Bach I, Rodriguez-Esteban C, Carrière C, et al. (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex.". Nat. Genet. 22 (4): 394–9. doi:10.1038/11970. PMID 10431247. 
  • Maekawa M, Ishizaki T, Boku S, et al. (1999). "Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.". Science 285 (5429): 895–8. doi:10.1126/science.285.5429.895. PMID 10436159. 
  • Edwards DC, Sanders LC, Bokoch GM, Gill GN (1999). "Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics.". Nat. Cell Biol. 1 (5): 253–9. doi:10.1038/12963. PMID 10559936. 
  • Ohashi K, Nagata K, Maekawa M, et al. (2000). "Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop.". J. Biol. Chem. 275 (5): 3577–82. doi:10.1074/jbc.275.5.3577. PMID 10652353. 
  • Martindale DW, Wilson MD, Wang D, et al. (2000). "Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23.". Mamm. Genome 11 (10): 890–8. doi:10.1007/s003350010166. PMID 11003705. 
  • Sumi T, Matsumoto K, Shibuya A, Nakamura T (2001). "Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha.". J. Biol. Chem. 276 (25): 23092–6. doi:10.1074/jbc.C100196200. PMID 11340065. 
  • Dan C, Kelly A, Bernard O, Minden A (2001). "Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin.". J. Biol. Chem. 276 (34): 32115–21. doi:10.1074/jbc.M100871200. PMID 11413130. 
  • Toshima J, Toshima JY, Takeuchi K, et al. (2001). "Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells.". J. Biol. Chem. 276 (33): 31449–58. doi:10.1074/jbc.M102988200. PMID 11418599. 

External links[edit]