List of Mendelian traits in humans
In Mendelian inheritance, a child receiving a dominant allele from either parent will have the dominant form of the trait. Only those that received the recessive allele from both parents present with the recessive phenotype. Those that receive a dominant allele from one parent and a recessive allele from the other parent will have the dominant form of the trait. Purely Mendelian traits are a tiny minority of all traits, since most phenotypic traits exhibit incomplete dominance, codominance, and contributions from many genes.
The recessive phenotype may theoretically skip any number of generations, lying dormant in heterozygous "carrier" individuals until they have children with someone who also has the recessive allele and both pass it on to their child.
These traits include:
- Wet (dominant) or dry (recessive) earwax - dry is found mostly in Asians and Native Americans
- Ability to taste phenylthiocarbamide (dominant) - largely determined by a single gene, TAS2R38, with two common alleles, though there are 8 possible haplotypes
- Albinism (recessive)
- Brachydactyly (shortness of fingers and toes)
- Lactase persistence (dominant)
May be Mendelian but there is conflicting evidence:
Traits previously believed to be Mendelian
- Eye color
- Hair color
- Morton's toe
- Tongue rolling
- Widow's peak (allele)
- Detached (dominant) or attached (recessive) earlobes
- Hitchhiker's thumb (recessive)
- Kim, U. K., E. Jorgenson, H. Coon, M. Leppert, N. Risch, and D. Drayna. 2003. Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science 299: 1221-1225
- Mange, Elaine J.; Mange, Arthur R. (1999). Basic Human Genetics (second ed.). Sunderland (MA): Sinauer. ISBN 0-87893-497-9. Lay summary (16 October 2010).
- Speicher, Michael R.; Antonarakis, Stylianos E.; Motulsky, Arno G., eds. (2010). Vogel and Motulsky's Human Genetics: Problems and Approaches. Heidelberg: Springer Scientific. doi:10.1007/978-3-540-37654-5. ISBN 978-3-540-37653-8. Lay summary (4 September 2010).