The river rises from an unnamed pond in Warwick near the intersection of Cowesett Road and Paddock Drive. From there, the river flows east along Cowesett Road, then turns southeast and flows past Interstate 95 to East Greenwich. The river then continues to its mouth at Greenwich Cove, on the north side of Potowomut Peninsula.
Below is a list of all crossings over the Maskerchugg River. The list starts at the headwaters and goes downstream.
- Cowesett Road (Twice)
- Interstate 95
- East Greenwich
Dark Entry Brook is the Maskerchugg River's only named tributary, though it has many unnamed streams that also feed it.
- Maps from the United States Geological Survey