Melanin-concentrating hormone

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Melanin-concentrating hormone
Symbol PMCH
CAS number 67382-96-1
Entrez 5367
HUGO 9109
OMIM 176795
RefSeq NM_002674
UniProt P20382
Other data
Locus Chr. 12 q23.2

Melanin-concentrating hormone (MCH) is a cyclic 19-amino acid orexigenic hypothalamic peptide originally isolated from the pituitary gland of teleost fish where it controls skin pigmentation.

In mammals it is involved in the regulation of feeding behavior, mood, sleep-wake cycle[1] and energy balance. MCH expressing neurons are located within the lateral hypothalamus and zona incerta. Despite this restricted distribution MCH neurons project widely throughout the brain. MCH knockout mice are hypophagic (eat less) and are lean. When administered centrally it increases food intake and weight gain.

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  1. ^ Verret L, Goutagny R, Fort P, Cagnon L, Salvert D, Léger L, Boissard R, Salin P, Peyron C, Luppi PH. (2003). "A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep". BMC Neurosci 4 (19): 19. doi:10.1186/1471-2202-4-19. PMC 201018. PMID 12964948. 

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