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Microsomal glutathione S-transferase 1

From Wikipedia, the free encyclopedia
MGST1
Identifiers
AliasesMGST1, GST12, MGST, MGST-I, microsomal glutathione S-transferase 1
External IDsOMIM: 138330; MGI: 1913850; HomoloGene: 10544; GeneCards: MGST1; OMA:MGST1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_019946
NM_001347489
NM_001361308
NM_001361309
NM_001361307

RefSeq (protein)

NP_001334418
NP_064330
NP_001348237
NP_001348238
NP_001348236

Location (UCSC)Chr 12: 16.35 – 16.61 MbChr 6: 138.12 – 138.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Microsomal glutathione S-transferase 1 is an enzyme that in humans is encoded by the MGST1 gene.[5]

Function

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The MAPEG family (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Four transcript variants of this gene encode one protein isoform.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000008394Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000008540Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: MGST1 microsomal glutathione S-transferase 1".

Further reading

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