He has also functioned as wicket-keeper. He made his ODI debut at Lords in 2003 scoring 17 in a very low scoring game. He is also the brother of fellow Eagles player Divan van Wyk. On 9 January 2011 in a Twenty20 International match against India, Morné scored the quickest half-century ever by a South African. It came off only 24 balls.
During the 2014-15 West Indian tour of South Africa, van Wyk scored a Twenty20 International century in the third T20I of the series, and by doing so became the third South African to score a T20I century.
^ "Even he if doesn't play for the Proteas in their T20 clash against India, Morné van Wyk is a strong candidate for the World T20."
^Knights too strong for Titans February 19, 2012 "A partnership of 97 runs between captain Morné van Wyk and Reeza Hendricks ensured the Knights got over the line in their T20 Challenge match against the Titans"