Music was in Nitti from the start. He grew up in the state of Georgia. Church was a place that Nitti would always find himself on Sundays. His first instrument of choice is the drums. Nitti began studying music while attending church with his family in south Georgia. As a young boy, he didn't have a father in his life to show him how to become a young man. His bio-father and mother divorced shortly after he was around the age of 2 years old. His dad played the bass guitar around the small churches in south Georgia. He was raised by his mother in Decatur, Georgia. His mother found her way into the music scene in Decatur, Georgia. She went on to become a gospel radio station program director in Atlanta, Georgia, from the early 1990s to the mid-2000s. Nitti would always sneak into the post production studios at the radio stations while at work with his mother. Nitti was raise, along with his only sister, by his mother in Decatur, Georgia. He began doing production for local rap acts in Atlanta, Georgia. He would then meet rap veteran 8ball (of 8Ball & MJG). He produced 7 songs on the sophomore album, "Almost Famous" by 8ball. One of the songs produced was a single titled "Stop Playin' Games. The record soared on the Billboard charts to become the 1st national hit record for Nitti. After meeting 8ball, Nitti began to work on production for the veteran that would later catch the attention of other major artists. Once Nitti established a name for himself, well known music mogul Jermaine Dupri approached Nitti with a production deal. He did production work on many projects released through the So So Def label including projects for Bow Wow, Jermaine Dupri, and other projects. In 2007, Nitti also secured a production deal with Warner Bros. Records in Los Angeles, California. In 2012, Nitti starting recording a new project called TGTN, along with rapper Don P (Lil Jon's group Trillville).
Nitti started his own record label in 2007. He has signed artists 9th Ward, Playa Shaw, PLP Pipeline, Da Robbin Cru, K-Camp, Myyko Montana, Yung F.A., and Nicole Wray. In 2010, he signed Atlanta rapper Mykko Montana to his company. In 2011, the single "Do It" was released to the internet. In 2012, Nitti sealed a distribution deal for his company, Playmaker Worldwide, with Universal Republic Records. He then launched the new company, "Nitti Beatz Recordings". Mykko Montana was the 1st artist signed to this new imprint. In 2013, due to Nitti and Universal not seeing the vision, Mykko Montana was released from both Nitti Beatz and Universal Republic Records. In 2015, Nitti produced the lead single on rapper Rich Homie Quan, entitled, "FLEX" (Ooh, Ooh, Ooh).
Most of Nitti's productions typically start with some form of a little kid or himself saying "It's a Nitti Beat!" and slightly more monologue before the song lyrics start. Nitti's sound is primarily sample-free, relying heavily on synthesized sounds. He has worked primarily with southern hip hop artists throughout his career and is credited with helping popularize "snap music" production with Yung Joc's "It's Goin' Down". In 2010, Nitti produced the single "Bring It Back" for the rap duo 8Ball & MJG. He was also nominated for a Grammy. On December 4th 2014 he signed artist Boonie Baby.