According to the National Gallery of Adelaide, Australia,
Piccinini has an ambivalent attitude towards technology and she uses her artistic practice as a forum for discussion about how technology impacts upon life. She is keenly interested in how contemporary ideas of nature, the natural and the artificial are changing our society. Specific works have addressed concerns about biotechnology, such as gene therapy and ongoing research to map the human genome... she is also fascinated by the mechanisms of consumer culture."
In a 2015 interview on ABC Radio, Piccinini made comments that some perceived as homophobic. In the interview, Sarah L'Estrange asked: "Why is this particularly the bravest thing you've done?". Piccinini replied: "because (the artwork) can be so easily dismissed. People could easily say ""Oh, look at that Horny Lezzo, making these repugnant images."" But it's not that. They're the opposite of that"