In December 2011, Jiráček signed a four-and-a-half year deal with German Bundesliga side VfL Wolfsburg. He immediately made an impression as he scored a brace in his fourth league game to secure a 3–2 win against SC Freiburg. He suffered an injury in the end of February, however, that led him to miss a number of matches and be on the bench a few times for the rest of the season.
On 26 August 2012, VfL Wolfsburg head coach Felix Magath confirmed that Jiráček would join Hamburger SV for an undisclosed fee after failing to impress him during his stay in Wolfsburg.
He went on to play a crucial part in the team that reached the quarterfinals of the UEFA Euro 2012, scoring two goals in the tournament, both opening goals against Greece and Poland in the group stage, being elected the man of the match in the latter match.