RGS14

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Regulator of G-protein signaling 14

PDB rendering based on 1kjy.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol RGS14
External IDs OMIM602513 MGI1859709 HomoloGene4735 GeneCards: RGS14 Gene
RNA expression pattern
PBB GE RGS14 38290 at tn.png
PBB GE RGS14 204280 at tn.png
PBB GE RGS14 211021 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10636 51791
Ensembl ENSG00000169220 ENSMUSG00000052087
UniProt O43566 P97492
RefSeq (mRNA) NM_006480 NM_016758
RefSeq (protein) NP_006471 NP_058038
Location (UCSC) Chr 5:
176.78 – 176.8 Mb
Chr 13:
55.37 – 55.38 Mb
PubMed search [1] [2]

Regulator of G-protein signaling 14 (RGS14) is a protein that in humans is encoded by the RGS14 gene.[1]

Function[edit]

RGS14 is a member of the regulator of G protein signalling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco motif. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[1]

Increasing the expression of the RGS14 protein in the V2 secondary visual cortex of mice promotes the conversion of short-term to long-term object-recognition memory.[2] Conversely RGS14 is enriched in CA2 pyramidal neurons and suppresses synaptic plasticity of these synapses and hippocampal-based learning and memory.[3]

Interactions[edit]

RGS14 has been shown to interact with:

References[edit]

  1. ^ a b "Entrez Gene: RGS14 regulator of G-protein signalling 14". 
  2. ^ López-Aranda MF, López-Téllez JF, Navarro-Lobato I, Masmudi-Martín M, Gutiérrez A, Khan ZU (July 2009). "Role of layer 6 of V2 visual cortex in object-recognition memory". Science 325 (5936): 87–9. doi:10.1126/science.1170869. PMID 19574389. Lay summaryMad Science. 
  3. ^ Lee SE, Simons SB, Heldt SA, Zhao M, Schroeder JP, Vellano CP, Cowan DP, Ramineni S, Yates CK, Feng Y, Smith Y, Sweatt JD, Weinshenker D, Ressler KJ, Dudek SM, Hepler JR (September 2010). "RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory". Proc Natl Acad Sci U S A 107 (39): 16994–8. doi:10.1073/pnas.1005362107. PMC 2947872. PMID 20837545. Lay summaryMedicalDaily. 
  4. ^ a b Kimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP (August 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". J. Biol. Chem. 276 (31): 29275–81. doi:10.1074/jbc.M103208200. PMID 11387333. 
  5. ^ Hollinger S, Taylor JB, Goldman EH, Hepler JR (December 2001). "RGS14 is a bifunctional regulator of Galphai/o activity that exists in multiple populations in brain". J. Neurochem. 79 (5): 941–9. doi:10.1046/j.1471-4159.2001.00629.x. PMID 11739605. 
  6. ^ Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP (April 2002). "Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits". Nature 416 (6883): 878–81. doi:10.1038/416878a. PMID 11976690. 
  7. ^ Shu FJ, Ramineni S, Amyot W, Hepler JR (January 2007). "Selective interactions between Gi alpha1 and Gi alpha3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization". Cell. Signal. 19 (1): 163–76. doi:10.1016/j.cellsig.2006.06.002. PMID 16870394. 

Further reading[edit]