Rowena Green Matthews

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Rowena Green Matthews is G. Robert Greenberg Distinguished University Professor Emeritus at the University of Michigan, Ann Arbor.[2] Her research focuses on the role of organic cofactors as partners of enzymes catalyzing difficult biochemical reactions, especially folic acid and cobalamin (vitamin B12). She is a Fellow of the National Academy of Sciences (elected 2002),[3] the Institute of Medicine (elected 2004),[4] the American Academy of Arts and Sciences (2005), the American Philosophical Society (2009) [5] and the American Academy of Microbiology (2002).

Early life and education

Matthews earned her B. A. in Biology, summa cum laude, from Radcliffe College in 1960. As an undergraduate, and for three years thereafter, she worked with George Wald and published a first author paper in which she first described a new intermediate in the bleaching of the visual pigment rhodopsin that temporally coincided with initiation of visual excitation.[6] She then went to graduate school in Biophysics at the University of Michigan, where she did her dissertation research in the laboratory of Vincent Massey. She received her Ph.D. in 1969.

Career

She was the Frederick Gowland Hopkins Lecturer at 12th International Conference of Pteridines and Folates.[7] She currently serves on the Medical Advisory Board of the Howard Hughes Medical Institute,[8] and on the Council of the National Academy of Sciences.[9] She is a member of the American Philosophical Society.[10]

Publications

[citation needed]

  • Matthews, R. G.; Hubbard, R.; Brown, P. K.; Wald, G. (1963). "Tautomeric forms of metarhodopsin". Journal of General Physiology. 47: 215–240. doi:10.1085/jgp.47.2.215. PMC 2195338. PMID 14080814.
  • Daubner, S. C.; Matthews, R. G. (1982). "Purification and properties of methylenetetrahydrofolate reductase from pig liver". Journal of Biological Chemistry. 257 (1): 140–145.
  • Banerjee, R. V.; Johnston, N. L.; Sobeski, J. K.; Datta, P.; Matthews, R. G. (1989). "Cloning and sequence analysis of the Escherichia coli metH gene encoding cobalamin-dependent methionine synthase and isolation of a tropic fragment containing the cobalamin-binding domain". Journal of Biological Chemistry. 264 (23): 13888–13895.
  • Goyette, P.; Sumner, J. S.; Milos, R.; Duncan, A. M. V.; Rosenblatt, D. S.; Matthews, R. G.; Rozen, R. (1994). "Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification". Nature Genetics. 7: 195–200. doi:10.1038/ng0694-195. PMID 7920641.
  • Frosst, P.; Blom, H. J.; Milos, R.; Goyette, P.; Sheppard, C. A.; Matthews, R. G.; Boers, G. J. H.; den Heijer, M.; Kluijtmans, L. A. J.; den Heuvel, L. P.; Rozen, R. (1995). "A candidate genetic risk factor for vascular disease: a common mutation in methyenetetrahydrofolate reductase". Nature Genetics. 10: 111–113. doi:10.1038/ng0595-111. PMID 7647779.
  • Drennan, C. L.; Huang, S.; Drummond, J. T.; Matthews, R. G.; Ludwig, M. L. (1994). "How a protein binds B12: a 3.0 Å x-ray structure of B12-binding domains of methionine synthase". Science. 266: 1669–1674. doi:10.1126/science.7992050. PMID 7992050.
  • González, J. C.; Peariso, K.; Penner-Hahn, J. E.; Matthews, R. G. (1996). "Cobalamin-independent methionine synthase from Escherichia coli: a zinc metalloenzyme". Biochemistry. 35: 12228–12234. doi:10.1021/bi9615452. PMID 8823155.
  • Ludwig, M. L.; Matthews, R. G. (1997). "Structure-based perspectives on B12-dependent enzymes". Annu. Rev. Biochem. 66: 269–313. doi:10.1146/annurev.biochem.66.1.269. PMID 9242908.
  • Goulding, C. W.; Postigo, D.; Matthews, R. G. (1997). "Cobalamin-dependent methionine synthase is a modular protein with distinct regions for binding homocysteine, methyltetrahydrofolate, cobalamin, and adenosylmethionine". Biochemistry. 36: 8082–8091. doi:10.1021/bi9705164.
  • Goulding, C. W.; Matthews, R. G. (1997). "Cobalamin-dependent methionine synthase from Escherichia coli:involvement of zinc in homocysteine activation". Biochemistry. 36: 15749–15757. doi:10.1021/bi971988l.
  • Guenther, B. D.; Sheppard, C. A.; Tran, P.; Rozen, R.; Matthews, R. G.; Ludwig, M. L. (1999). "The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia". Nature Structural Biology. 6: 359–365. doi:10.1038/7594.
  • Bandarian, V.; Pattridge, K. A.; Lennon, B. W.; Huddler, D. P.; Matthews, R. G.; Ludwig, M. L. (2001). "Domain alteration switches B12-dependent methionine synthase to the activation conformation". Nature Structural Biology. 9: 53–56. doi:10.1038/nsb738. PMID 11731805.
  • Bandarian, V.; Ludwig, M. L.; Matthews, R. G. (2003). "Factors modulating conformational equilibria in large modular proteins: a case study with cobalamin-dependent methionine synthase". Proc. Natl. Acad. Sci. USA. 100: 8156–8163. doi:10.1073/pnas.1133218100.
  • Koutmos, M.; Pejchal, R.; Bomer, T. M.; Matthews, R. G.; Smith, J. L.; Ludwig, M. L. (2008). "Metal active site elasticity linked to activation of homocysteine in methionine synthases". Proc. Natl. Acad. Sci. USA. 105: 3286–3291. doi:10.1073/pnas.0709960105.
  • Matthews, R. G. (2009) Cobalamin- and corrinoid-dependent enzymes, in Metal Carbon Bonds in Enzymes and Cofactors, 6, Metal Ions in Life Sciences, Sigel, A., Sigel, H., and Sigel, R. K. O., eds. RSC Publishing, Cambridge UK, pp. 53–114.
  • Koutmos, M.; Datta, S.; Pattridge, K. A.; Smith, J. L.; Matthews, R. G. (2009). "Insights into the reactivation of cobalamin-dependent methionine synthase". Proc. Natl. Acad. Sci. USA. 106: 18527–18532. doi:10.1073/pnas.0906132106.

References

  1. ^ Matthews, Rowena G.; Ruth Hubbard; Paul K. Brown; George Wald (1963). "Tautomeric forms of metarhodopsin". Journal of General Physiology. 47: 215–240. doi:10.1085/jgp.47.2.215. PMC 2195338. PMID 14080814.
  2. ^ Matthews, Rowena. "Rowena Matthews-University of Michigan Department of Biological Chemistry". Archived from the original on July 30, 2013. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  3. ^ Matthews, Rowena. "Rowena Matthews-National Academy of Sciences".
  4. ^ Matthews, Rowena. "Directory: IOM Member-Rowena G. Matthews, Ph.D." Global directory.
  5. ^ Matthews, Rowena. "Institute News: American Philosophical Society Honors HHMI scientists and board members". American Philosophical Society.
  6. ^ Matthews, Rowena G.; Ruth Hubbard; Paul K. Brown; George Wald (1963). "Tautomeric forms of metarhodopsin". Journal of General Physiology. 47: 215–240. doi:10.1085/jgp.47.2.215. PMC 2195338. PMID 14080814.
  7. ^ http://books.google.com/books?id=CvwnJmFmGcIC&pg=PR21&lpg=PR21&dq=Rowena+Green+Matthews&source=bl&ots=80jfeHTUpo&sig=tGZBm9tbdD3Q8xp6qFRyzEWBV0Y&hl=en&sa=X&ei=tjDHUtL-C864yAG4hYDgBQ&ved=0CDgQ6AEwBDgU#v=onepage&q=Rowena%20Green%20Matthews&f=false
  8. ^ "Medical Advisory Board". Howard Hughes Medical Institute. Retrieved 25 March 2015.
  9. ^ "Leadership and Governance". National Academy of Sciences. Retrieved 25 March 2015.
  10. ^ http://www.amphilsoc.org/memhist/search?creator=Rowena+Matthews&title=&subject=&subdiv=&mem=&year=&year-max=&dead=&keyword=&smode=advanced
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