SAFB2

SAFB2
Identifiers
Aliases	SAFB2, scaffold attachment factor B2
External IDs	OMIM: 608066 MGI: 2146808 HomoloGene: 35210 GeneCards: SAFB2
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.3 Start 5,586,999 bp End 5,624,046 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 D Start 56,560,965 bp End 56,584,585 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary right uterine tube sural nerve canal of the cervix right lobe of thyroid gland left lobe of thyroid gland right adrenal gland nucleus accumbens left uterine tube right lobe of liver Top expressed in yolk sac superior frontal gyrus thymus lip cerebellar cortex Paneth cell secondary oocyte crypt of lieberkuhn of small intestine lens spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleic acid binding identical protein binding protein binding double-stranded DNA binding RNA binding sequence-specific DNA binding Cellular component extracellular exosome nucleoplasm cytoplasm intracellular membrane-bounded organelle nucleus nuclear body Biological process regulation of transcription, DNA-templated transcription, DNA-templated Sertoli cell differentiation regulation of transcription by RNA polymerase II regulation of androgen receptor signaling pathway regulation of mRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9667 224902 Ensembl ENSG00000130254 ENSMUSG00000042625 UniProt Q14151 Q80YR5 RefSeq (mRNA) NM_014649 NM_001029979 NM_001355463 RefSeq (protein) NP_055464 NP_001025150 NP_001342392 Location (UCSC) Chr 19: 5.59 – 5.62 Mb Chr 17: 56.56 – 56.58 Mb PubMed search
Wikidata
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Scaffold attachment factor B2 is a protein that in humans is encoded by the SAFB2 gene.

Interactions

SAFB2 has been shown to interact with Estrogen receptor alpha and SAFB.

Further reading

• Oesterreich S (2003). "Scaffold attachment factors SAFB1 and SAFB2: Innocent bystanders or critical players in breast tumorigenesis?". J. Cell. Biochem. 90 (4): 653–61. doi:10.1002/jcb.10685. PMID 14587024. S2CID 39178501.
• Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. CiteSeerX 10.1.1.333.6945. doi:10.1093/dnares/2.4.167. PMID 8590280.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (2004). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.