SMURF2

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SMAD specific E3 ubiquitin protein ligase 2
Protein SMURF2 PDB 1zvd.png
PDB rendering based on 1zvd.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SMURF2 ; DKFZp686F0270; MGC138150
External IDs OMIM605532 MGI1913563 HomoloGene41490 GeneCards: SMURF2 Gene
RNA expression pattern
PBB GE SMURF2 205596 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 64750 66313
Ensembl ENSG00000108854 ENSMUSG00000018363
UniProt Q9HAU4 A2A5Z6
RefSeq (mRNA) NM_022739 NM_025481
RefSeq (protein) NP_073576 NP_079757
Location (UCSC) Chr 17:
62.54 – 62.66 Mb
Chr 11:
106.82 – 106.92 Mb
PubMed search [1] [2]

E3 ubiquitin-protein ligase SMURF2 is an enzyme that in humans is encoded by the SMURF2 gene.[1][2]


Interactions[edit]

SMURF2 has been shown to interact with Mothers against decapentaplegic homolog 7,[3][4][5] SCYE1,[5] SMURF1,[6] Mothers against decapentaplegic homolog 3,[1][7][8] Ubiquitin C,[5][9] Mothers against decapentaplegic homolog 1[1] and Mothers against decapentaplegic homolog 2.[1][7][8]

References[edit]

  1. ^ a b c d Lin X, Liang M, Feng XH (January 2001). "Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling". J Biol Chem 275 (47): 36818–22. doi:10.1074/jbc.C000580200. PMID 11016919. 
  2. ^ "Entrez Gene: SMURF2 SMAD specific E3 ubiquitin protein ligase 2". 
  3. ^ Asano, Yoshihide; Ihn Hironobu, Yamane Kenichi, Kubo Masahide, Tamaki Kunihiko (January 2004). "Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts". J. Clin. Invest. (United States) 113 (2): 253–64. doi:10.1172/JCI16269. ISSN 0021-9738. PMC 310747. PMID 14722617. 
  4. ^ Kavsak, P; Rasmussen R K, Causing C G, Bonni S, Zhu H, Thomsen G H, Wrana J L (Dec 2000). "Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation". Mol. Cell (United States) 6 (6): 1365–75. doi:10.1016/S1097-2765(00)00134-9. ISSN 1097-2765. PMID 11163210. 
  5. ^ a b c Lee, Yeon Sook; Han Jung Min, Son Sung Hwa, Choi Jin Woo, Jeon Eun Ju, Bae Suk-Chul, Park Young In, Kim Sunghoon (July 2008). "AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2". Biochem. Biophys. Res. Commun. (United States) 371 (3): 395–400. doi:10.1016/j.bbrc.2008.04.099. PMID 18448069. 
  6. ^ Fukunaga, Erina; Inoue Yasumichi, Komiya Setsuro, Horiguchi Kana, Goto Kouichiro, Saitoh Masao, Miyazawa Keiji, Koinuma Daizo, Hanyu Aki, Imamura Takeshi (Dec 2008). "Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells". J. Biol. Chem. (United States) 283 (51): 35660–7. doi:10.1074/jbc.M710496200. ISSN 0021-9258. PMID 18927080. 
  7. ^ a b Bonni, S; Wang H R, Causing C G, Kavsak P, Stroschein S L, Luo K, Wrana J L (June 2001). "TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation". Nat. Cell Biol. (England) 3 (6): 587–95. doi:10.1038/35078562. ISSN 1465-7392. PMID 11389444. 
  8. ^ a b Nakano, Ayako; Koinuma Daizo, Miyazawa Keiji, Uchida Takafumi, Saitoh Masao, Kawabata Masahiro, Hanai Jun-ichi, Akiyama Hirotada, Abe Masahiro, Miyazono Kohei, Matsumoto Toshio, Imamura Takeshi (March 2009). "Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins". J. Biol. Chem. (United States) 284 (10): 6109–15. doi:10.1074/jbc.M804659200. ISSN 0021-9258. PMID 19122240. 
  9. ^ Carpentier, Isabelle; Coornaert Beatrice, Beyaert Rudi (October 2008). "Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation". Biochem. Biophys. Res. Commun. (United States) 374 (4): 752–7. doi:10.1016/j.bbrc.2008.07.103. PMID 18671942. 

Further reading[edit]