He was born at St Mabon, Cornwall, UK. From 1683 to 1686 he attended a school at Newington Green (near London) conducted by the Rev. Charles Morton (1627–1698), a dissenting clergyman, with whom he emigrated to Massachusetts in 1686. He was commissioned by the Society for the Propagation of the Gospel in New England to study the Indian languages and to preach to the Indians; but he was soon diverted from this work. Removing to Portsmouth, New Hampshire, he there married Mary Cutt, a daughter of John Cutt (1625–1681), president of the province of New Hampshire in 1679, a successful merchant and mill-owner, and thus came into possession of considerable property (including much of the present site of Portsmouth). In 1700 he was speaker of the Assembly and in 1702 became a member of the Provincial Council, but was suspended by Lieutenant-Governor George Vaughan (1676–1724). Penhallow, however, was sustained by Governor Samuel Shute (1662–1742), and Vaughan was removed from office in 1716. In 1714 Penhallow was appointed a justice of the superior court of judicature, and from 1717 until his death was chief justice of that court; and he also served as treasurer of the province in 1699–1726, and as secretary of the province in 1714–1726. He died at Portsmouth on 2 December 1726.
He wrote a History of the Wars of New-England with the Eastern Indians, or a Narrative of their Continued Perfidy and Cruelty (1726 reprinted in the Collections of the New Hampshire Historical Society, vol. i., 1824, and again at Cincinnati in 1859), which covers the period from 1703 to 1726, and is a standard contemporary authority.
- Penhallow, Samuel; Adams, Nathaniel; Colman, Benjamin (1859). History of the Wars of New-England with the Eastern Indians, or a Narrative of their Continued Perfidy and Cruelty. Philadelphia.
- This article incorporates text from a publication now in the public domain: Chisholm, Hugh, ed. (1911). Encyclopædia Britannica (11th ed.). Cambridge University Press