Always known as a turbulent couple, the Spewaks were in the midst of their own marital woes in 1948 when they were approached to write the book for Kiss Me, Kate, which centered on a once-married couple of thespians who use the stage on which they're performing as a battling ground. Bella initially began working with composerCole Porter on her own, but theatrical necessity overcame marital sparks, and the Spewacks completed the project together. It yielded each of them two Tony Awards, one for Best Musical, the other for Best Author of a Musical. Kiss Me, Kate proved to be their most successful work.
In 1965, Sam collaborated with Frank Loesser on a musical adaptation of the 1961 Spewack play Once There Was a Russian. Entitled Pleasures and Palaces, it closed following its Detroit run and never opened on Broadway.
A Letter to Sam from Bella, a one-act play by Broadway director Aaron Frankel, is based on the Spewacks' personal papers from the Theater Arts Collection of Columbia University's Rare Book and Manuscript Library.