Specific appetite

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Specific appetite, also known as specific hunger, is a drive to eat foods with specific flavors or other characteristics.[1]

Regulation of homeostasis is essential to the survival of animals. Because the nutritional content of a diet will vary with environmental and other conditions, it is useful for animals to have a mechanism to ensure that their nutritional needs are within the appropriate range. Specific appetite is one such mechanism. Specific appetite has been demonstrated in various species for a number of vitamins and minerals, as well as calories, protein, and water. Unfortunately, specific appetite is very difficult to study experimentally, as there are a number of factors that influence food choice. Very little is known about the specific mechanisms inducing specific appetite, and the genes encoding for specific appetites are mostly speculative.

Very few specific appetites for particular nutrients have been identified in humans. The most robustly identified are salt appetite/sodium appetite. The problem with many other nutrients is that they do not have distinctly identifiable tastes, and only two other specific appetites, for iron and calcium, have been identified with experimental rigour so far. Other appetites are thus currently classified as learned appetites, which are not innate appetites that are triggered automatically in the absence of certain nutrients, but learned behaviours, aversions to or preferences for certain foods as they become associated with experiences of malnutrition and illness.[1]

Learned appetite[edit]

If a food source has an identifiable flavor, an animal can learn to associate the positive effects of alleviation of a certain nutrient deficiency with consumption of that food. This has been demonstrated in a variety of species: lambs offered free choice of various foods will compensate for phosphorus, sodium, and calcium deficiencies.[2] Domestic fowl have demonstrated specific appetites for calcium, zinc, and phosphorus, thiamine, protein in general, and methionine and lysine. Heat-stressed fowls seek out vitamin C, which alleviates the consequences of heat stress [3] Learned specific appetites are not necessarily a result of an animal's ability to detect the presence of a nutrient. Because nutrient deficiencies of various types can have stressful effects which vary depending on the missing nutrient, subsequent ingestion of that nutrient is associated with relief of certain signs. An animal may therefore associate the flavor of a food that is high in a certain nutrient with relief of the signs of that nutrient deficiency, while not seeking out other foods rich in the same nutrient.

Unlearned appetite[edit]

An unlearned appetite is one that an animal possesses at birth, without conditioning through prior stress followed by alleviation with specific foods. An unlearned appetite suggests a physiological mechanism for detecting the absence of a nutrient as well as a signalling component that directs the animal to seek out the missing nutrient. An example of an unlearned appetite might be caloric appetite, as seen in all domestic animals. Other unlearned appetites are more difficult to demonstrate. In one study, protein-deficient rats that had not previously experienced protein deficiency demonstrated strong preferences for high-protein foods such as soybean, gluten, and ovalbumin within thirty minutes of food presentation. This preference was not seen in controls, and was also exhibited by pregnant females with higher protein needs who were not experimentally protein-deficient.[4] Rats also seem to have an unlearned appetite for calcium and sodium.[5] In addition, zinc-depleted chicks show preferences for zinc-rich feeds.[6]

Indirect manipulation of specific appetite[edit]

Specific appetite can be indirectly induced under experimental circumstances. In one study, normal (sodium-replete) rats exposed to angiotensin II via infusion directly into the brain developed a strong sodium appetite which persisted for months.[7] However, the conclusions of this experiment have been contested.[8] Nicotine implants in rats have been shown to induce a specific appetite for sucrose, even after removal of the implants.[9]

Specific appetite in humans[edit]

There is very little strong evidence for specific appetite in humans. However, it has been demonstrated that humans have the ability to taste calcium,[10] and indirect evidence supports the idea that patients on kidney dialysis who develop hypocalcemia prefer cheese with greater amounts of calcium added.[11] Exercise also increases the preference for salt.[12] Addison’s disease is known to induce a specific craving for sodium, although other diseases causing hyponatremia may not induce the same response.[13] Extreme sodium depletion in human volunteers has been demonstrated to increase the desire for high-salt foods.[14]

Ongoing research[edit]

While the most common nutritional disorders in humans concern excessive intake of calories, malnutrition remains a problem. For example, the link between insufficient dietary calcium and bone disorders is well established [15]

References[edit]

  1. ^ a b Kent C. Berridge (2001). "malnutrition". In Philip Winn. Dictionary of Biological Psychology. CRC Press. pp. 957–958. ISBN 9780203298848. ISBN 0-203-29884-5. 
  2. ^ Villalba, Provenza, Hall, Learned appetites for calcium, phosphorus, and sodium in sheep. Journal of Animal Science, 2008.86:738-747
  3. ^ Sahin, Sahin, Onderci, Gursu, Issi, 2002: Effects of vitamin C and vitamin E on lipid peroxidation status, serum hormone, metabolite, and mineral concentrations of Japanese quails reared under heat stress (34 degrees C), International Journal for Vitamin and Nutrition Research
  4. ^ J.A. Deutsh, Unlearned specific appetite for protein. Physiology and Behavior, 1989; 46(4):619-624
  5. ^ Tordoff, 1994
  6. ^ Hughes, Dewar, A specific appetite for zinc in zinc-depleted domestic fowls. British poultry Science, 1971
  7. ^ Bryant, Epstein, Fitzsimons, and Fluharty. Arousal of a specific and persistent sodium appetite in the rat with continuous intracerebroventricular infusion of angiotensin II.
  8. ^ Rohla, Gaal, Kiss, and Kocsis, Intracerebroventricular antiotensin II injection does not elicit specific appetite for sodium in the rat. Acta Physiol Acad Sci Hung, 1981; 58(3):169-80
  9. ^ Jias and Ellison, Chronic nicotine induces a specific appetite for sucrose in rats. Pharmacology, biochemistry and behavior, 1990:35(2) 489-491
  10. ^ Schiffman, 1971
  11. ^ Weaver and Heaney, Calcium in Human Health. Springer, 2006, 169
  12. ^ Lesham, Abutbul and Eilon, Exercise Increases the Preference for Salt in Humans. Appetite, 1999; 32(2): 251-260
  13. ^ Kochli, Tenenbaum-Rakover, Leshem. Increased salt appetite in patients with CAH-21-OH deficiency (congenital adrenal hyperplasia). Am J Physiol Regul Inegr Comp Physiol, Jan 13 2005
  14. ^ Beauchamp, Bertino, Burke and Engelman. Experimental sodium depletion and salt taste in normal human volunteers. American Journal of Clinical Nutrition, 1990; 51:881-889
  15. ^ Cumming, Calcium intake and bone mass: a quantitative review of the evidence. Calcified Tissue International, 2007; 47(4): 194-201

Further reading[edit]

  • Robert J. Contreras (1989). "Gustatory mechanisms of a specific appetite". In Robert H. Cagan. Neural mechanisms in taste (494). CRC Press. ISBN 9780849358340.