From its southern terminus in Hoschton at SR 53, the route runs east, and then northeast to an intersection with SR 124. SR 332 then continues to the northeast, where it crosses -- without intersecting -- Interstate 85 (I-85). The route then continues to the northeast until it reaches Pendergrass.
The route then begins a zigzag route to the northwest, alternating to the southwest and the north. Northwest of Talmo, SR 332 has a concurrency with SR 60 and an intersection with SR 211. The route then continues in a general northwest direction to its northern terminus at SR 13 in Oakwood. The route's northern terminus is about 0.1 miles (0.16 km) from having a second intersection with SR 53.