Streptomyces hygroscopicus

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Streptomyces hygroscopicus
Scientific classification
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Actinomycetales
Family: Streptomycetaceae
Genus: Streptomyces
Species: S. hygroscopicus
Binomial name
Streptomyces hygroscopicus
(Jensen[disambiguation needed] 1931) Waksman and Henrici 1948
Subspecies

S. hygroscopicus angustmyceticus
S. hygroscopicus decoyicus
S. hygroscopicus glebosus
S. hygroscopicus hygroscopicus
S. hygroscopicus ossamyceticus

Synonyms

Actinomyces hygroscopicus Jensen 1931[1]

Streptomyces hygroscopicus is a bacterial species in the genus Streptomyces.

Biochemistry[edit]

S. hygroscopicus cultures can be used to produce a number of chemical compounds or enzymes.

Chemicals[edit]

Immunosuppressants[edit]

Sirolimus (also known as rapamycin) is an immunosuppressant that has been isolated from S. hygroscopicus from soil samples from Easter Island. Ascomycin can be used to treat autoimmune diseases and skin diseases, and can help prevent rejection after an organ transplant.

Antibiotics[edit]

The antibiotics geldanamycin, hygromycin B, nigericin, validamycin, and cyclothiazomycin are found in S. hygroscopicus.

Experimental cancer drugs[edit]

Indolocarbazoles can be found in S. hygroscopicus .

Anthelmintics and insecticides[edit]

Milbemycin and milbemycin oxime can be found in S. hygroscopicus cultures.

Herbicide[edit]

S. hygroscopicus also produces the natural herbicide bialaphos.[2]

Enzymes[edit]

The enzymes alpha,alpha-trehalose-phosphate synthase (GDP-forming), carboxyvinyl-carboxyphosphonate phosphorylmutase and hygromycin-B kinase can be isolated from cultures of S. hygroscopicus.

References[edit]

  1. ^ Streptomyces hygroscopicus on biocyc.org
  2. ^ The bialaphos biosynthetic genes of Streptomyces hygroscopicus: Molecular cloning and characterization of the gene cluster. Takeshi Murakami, Hiroyuki Anzai, Satoshi Imai, Atsuyuki Satoh, Kozo Nagaoka and Charles J. Thompson, Molecular and General Genetics MGG, Volume 205, Number 1, pages 42-53, doi:10.1007/BF02428031

External links[edit]