Talk:Ascites

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Historical Correlate[edit]

I particularly enjoy the statement "Comparable is also Numeri 5:11ff, where a confirmed adulteress is punished with swelling of the abdomen."

Might they be referring to pregnancy?

12.210.82.110 22:14, 21 March 2007 (UTC) bwhitehurst81


Methods[edit]

Is it worth mentioning that, in the past, one of the methods of propagating tissue culture cells was to propagate them in the peritoneum of syngeneic mice, and that this caused ascites formation? They even used to generate antibodies by injecting mice with monoclonal B-cells.... user:Fhayashi

I'm not sure... it sounds like a footnote in the annals of science, IMHO. JFW | T@lk 20:43, 12 July 2005 (UTC)
The tissue culture method might be, but as a method of making antibodies from hybridomas, it's definitely not - it's still very widely used. In fact, i believe it's the standard way of making monoclonal antibodies, as it's easy, cheap, gives very high concentrations, and doesn't need much purification afterwards, none of which are true of growing hybridomas in culture. Certainly, plenty of the antibodies in my lab's freezer are ascites fluid. I think this method is now banned in the EU on animal welfare grounds, but it's still done in the US. -- Tom Anderson 3/1/2008 2159 +0000 —Preceding unsigned comment added by 128.40.81.216 (talk) 21:59, 3 January 2008 (UTC)

BSG guidelines[edit]

Prof Moore and Dr Aithal have written a guideline for the management of cirrhotic ascites. May be worth using for the paragraphs on management[1]. JFW | T@lk 15:28, 12 September 2006 (UTC)

It's a very comprehensive guideline. I'll see if I can work it into this article. JFW | T@lk 22:53, 3 October 2006 (UTC)

B-cells[edit]

It's correct, even B-cells could be cultured in this ascitic areas to accomplish monoclonal antibody production. Ascites also exist in human cancers, like pancreatic cancer.

B cells? You mean beta cells? Or do you suggest cytology is sent? The article already mentions cancer. JFW | T@lk 22:53, 3 October 2006 (UTC)

Not mineralocorticoid[edit]

doi:10.1002/hep.21699 - the role of the RAS system may be overvalued. JFW | T@lk 16:39, 27 June 2007 (UTC)

negative SAAG[edit]

If SAAG = ascites albumin - serum albumin, what happens when the ascites have lower albumin than the serum? Is that still exudative?

71.234.109.192 (talk) 02:19, 11 September 2008 (UTC)

this article is quite out of date. as a practicing hepatologist, we have not characterized ascites as exudative vs transudative in over a decade. It is characterized by a high vs low SAAG. SAAG is defined by (serum albumin - ascites albumin). It is a simple mathematical calculation that correlates very well with whether or not the ascites is due to portal hypertension or not. If not, (a low SAAG) then the cause is peritoneal (=abdominal infection or bowel perforation or malignancy, etc) and has nothing to do with the liver or the heart. This does not respond to diuretics

As to your question: ascites always has a lower albumin than serum. The question is how much lower. >1.1 is significant (a high SAAG) and less is a low SAAG (i.e a peritoneal cause of ascites).

In summary, ascites is generally caused by above the liver (high lung or heart pressures), the liver (cirrhosis, or hepatic vein thrombosis) or peritoneal. Only peritoneal has a low SAAG.

If it would helpful I can email you an article I published as a summary on the workup of ascites.

dfdies@yahoo.com

david f. dies, md, mba03:15, 9 January 2010 (UTC) —Preceding unsigned comment added by Dfdies (talkcontribs)

Pronunciation[edit]

With all the mispronunciations heard in House, MD and other medical shows, it may be a good idea to add a pronuciation key to either this article or the Wiktionary entry for ascites. --NetRolller 3D 19:09, 13 December 2009 (UTC)

Indeed. I can think of about 12 different possible ways to pronounce this, from "ass-ites" to "az-kuh-teez" to "ah-shee-tess". — SMcCandlish Talk⇒ ʕ(Õلō Contribs. 05:33, 27 March 2010 (UTC)