Talk:Silybum marianum
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Yeah, you know what I'm thinking...[edit]
Is it muscarine or muscimol that it acts against? --Ceriel Nosforit 11:53, 16 May 2007 (UTC)
Antidote for Death Cap (Amanita phalloides)[edit]
The Death Cap (Amanita phalloides) article asserts that there is no known antidote. —Preceding unsigned comment added by 24.165.10.183 (talk) 21:10, 22 May 2008 (UTC)
According to the most recent article on death cap: "Some evidence indicates intravenous silibinin, an extract from the blessed milk thistle (Silybum marianum), may be beneficial in reducing the effects of death cap poisoning. A long-term clinical trial of intravenous silibinin began in the US in 2010.[75] Silibinin prevents the uptake of amatoxins by liver cells, thereby protecting undamaged liver tissue; it also stimulates DNA-dependent RNA polymerases, leading to an increase in RNA synthesis.[76][77][78] According to one report[79] based on a treatment of 60 patients with silibinin, the patients who have started the drug within 96 hours of ingesting the mushroom and who have still had kidney function intact have all survived. As of February 2014 supporting research hasn’t yet been published." should this be included in the article?--192.222.231.138 (talk) 17:51, 2 May 2016 (UTC)
- Link to the article? Alexbrn (talk) 17:59, 2 May 2016 (UTC)
- https://en.wikipedia.org/wiki/Amanita_phalloides and 75-79 are the sources in question. --192.222.231.138 (talk) 18:20, 3 May 2016 (UTC)
Here is a link to a formal paper on the antidotal effects of a milk thistle extract for Amanita poisoning: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414726/ — Preceding unsigned comment added by 2601:346:580:1FD0:EDB0:AD23:570D:7F4E (talk) 18:05, 8 May 2020 (UTC)
Christian folklore[edit]
The article should cover the Christian legendary beliefs about the plant and it's connection to the Virgin Mary. --Willthacheerleader18 (talk) 22:29, 27 November 2010 (UTC)
Region of Origin?[edit]
The uncited paragraph under "Distribution and habitat" claims it is "possibly native near the coast of southeast England". Then the next paragraph says, "The plant originates from mountains of the Mediterranean region". What's the story? --Arabicas.Filerons (talk) 06:41, 1 May 2015 (UTC)