Tuff started his career in 1969 as a member of the vocal trio The African Brothers, along with Sugar Minott and Derrick "Bubbles" Howard. The African Brothers split up in the mid-1970s, and Tuff pursued other work outside music until he returned as a solo artist in the late 1970s, with the album Tony Tuff Meets Errol Schorder [sic], split with Errol Scorcher, and self-productions including the "I'm So Glad" single on his own Winston label. He worked with Yabby You on the Tony Tuff album in 1980, and worked with Minott again on the 1981 album Presenting Mr. Tuff, released on Minott's Black Roots label. He worked on several sound systems in the late 1970s and 1980s, including Lees Unlimited and Henry "Junjo" Lawes' Volcano system. Lawes also produced several successful singles by Tuff including "Water Pumpee", and "Mix Me Down", and also produced his 1983 album Come Fe Mash It. He continued to be active during the 1980s, but was largely absent from the music scene in the 1990s. He returned in 2000, and has recorded several albums in the new millennium, including How Long, recorded with Jah Shaka. He toured Europe twice in 2002, before touring Canada and the United States.