From Wikipedia, the free encyclopedia
Ubiquitin conjugation factor E4 A is a protein that in humans is encoded by the UBE4A gene .[ 5] [ 6]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.
Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes , or E1s, ubiquitin-conjugating enzymes , or E2s, and ubiquitin-protein ligases , or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly.[ 6]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000110344 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059890 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Koegl M, Hoppe T, Schlenker S, Ulrich HD, Mayer TU, Jentsch S (Apr 1999). "A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly" . Cell . 96 (5): 635–44. doi :10.1016/S0092-8674(00)80574-7 . PMID 10089879 .
^ a b "Entrez Gene: UBE4A ubiquitination factor E4A (UFD2 homolog, yeast)" .
Further reading
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics . 23 (1): 42–50. doi :10.1006/geno.1994.1457 . PMID 7829101 .
Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1" . DNA Res . 2 (4): 167–74, 199–210. doi :10.1093/dnares/2.4.167 . PMID 8590280 .
Mahoney JA, Odin JA, White SM, et al. (2002). "The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis" . Biochem. J . 361 (Pt 3): 587–95. doi :10.1042/0264-6021:3610587 . PMC 1222341 . PMID 11802788 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol . 21 (5): 566–9. doi :10.1038/nbt810 . PMID 12665801 . S2CID 23783563 .
Contino G, Amati F, Pucci S, et al. (2004). "Expression analysis of the gene encoding for the U-box-type ubiquitin ligase UBE4A in human tissues". Gene . 328 : 69–74. doi :10.1016/j.gene.2003.11.017 . PMID 15019985 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Spinette S, Lengauer C, Mahoney JA, et al. (2006). "Ufd2, a novel autoantigen in scleroderma, regulates sister chromatid separation" . Cell Cycle . 3 (12): 1638–44. doi :10.4161/cc.3.12.1345 . PMID 15611659 .
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 . PMID 17353931 .