UNC13B

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Unc-13 homolog B (C. elegans)
Identifiers
Symbols UNC13B ; MUNC13; UNC13; Unc13h2
External IDs OMIM605836 MGI1342278 HomoloGene31376 GeneCards: UNC13B Gene
Orthologs
Species Human Mouse
Entrez 10497 22249
Ensembl ENSG00000198722 ENSMUSG00000028456
UniProt O14795 Q9Z1N9
RefSeq (mRNA) NM_006377 NM_001081413
RefSeq (protein) NP_006368 NP_001074882
Location (UCSC) Chr 9:
35.16 – 35.41 Mb
Chr 4:
43.06 – 43.26 Mb
PubMed search [1] [2]

Protein unc-13 homolog B is a protein that in humans is encoded by the UNC13B gene.[1][2]

This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.[2]

Interactions[edit]

UNC13B has been shown to interact with STX1B,[3] STX1A,[3] RIMS1,[4][5] SPTBN2[6] and DOC2A.[7][8]

References[edit]

  1. ^ Song Y, Ailenberg M, Silverman M (August 1998). "Cloning of a novel gene in the human kidney homologous to rat munc13s: its potential role in diabetic nephropathy". Kidney Int 53 (6): 1689–95. doi:10.1046/j.1523-1755.1998.00942.x. PMID 9607201. 
  2. ^ a b "Entrez Gene: UNC13B unc-13 homolog B (C. elegans)". 
  3. ^ a b Betz, A; Okamoto M; Benseler F; Brose N (January 1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin". J. Biol. Chem. (UNITED STATES) 272 (4): 2520–6. doi:10.1074/jbc.272.4.2520. ISSN 0021-9258. PMID 8999968. 
  4. ^ Betz, A; Thakur P; Junge H J; Ashery U; Rhee J S; Scheuss V; Rosenmund C; Rettig J; Brose N (April 2001). "Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming". Neuron (United States) 30 (1): 183–96. doi:10.1016/S0896-6273(01)00272-0. ISSN 0896-6273. PMID 11343654. 
  5. ^ Ohtsuka, Toshihisa; Takao-Rikitsu Etsuko, Inoue Eiji, Inoue Marie, Takeuchi Masakazu, Matsubara Kaho, Deguchi-Tawarada Maki, Satoh Keiko, Morimoto Koji, Nakanishi Hiroyuki, Takai Yoshimi (August 2002). "Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1". J. Cell Biol. (United States) 158 (3): 577–90. doi:10.1083/jcb.200202083. ISSN 0021-9525. PMC 2173811. PMID 12163476. 
  6. ^ Sakaguchi, G; Orita S; Naito A; Maeda M; Igarashi H; Sasaki T; Takai Y (July 1998). "A novel brain-specific isoform of beta spectrin: isolation and its interaction with Munc13". Biochem. Biophys. Res. Commun. (UNITED STATES) 248 (3): 846–51. doi:10.1006/bbrc.1998.9067. ISSN 0006-291X. PMID 9704016. 
  7. ^ Orita, S; Naito A; Sakaguchi G; Maeda M; Igarashi H; Sasaki T; Takai Y (June 1997). "Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery". J. Biol. Chem. (UNITED STATES) 272 (26): 16081–4. doi:10.1074/jbc.272.26.16081. ISSN 0021-9258. PMID 9195900. 
  8. ^ Mochida, S; Orita S; Sakaguchi G; Sasaki T; Takai Y (September 1998). "Role of the Doc2α–Munc13–1 interaction in the neurotransmitter release process". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (19): 11418–22. doi:10.1073/pnas.95.19.11418. ISSN 0027-8424. PMC 21657. PMID 9736751. 

Further reading[edit]