IDH2: Difference between revisions

IDH2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4JA8
Identifiers
Aliases	IDH2, D2HGA2, ICD-M, IDH, IDHM, IDP, IDPM, mNADP-IDH, isocitrate dehydrogenase (NADP(+)) 2, mitochondrial, isocitrate dehydrogenase (NADP(+)) 2, IDH-2
External IDs	OMIM: 147650; MGI: 96414; HomoloGene: 37590; GeneCards: IDH2; OMA:IDH2 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	90,102,477 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	79,765,140 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; gastrocnemius muscle; ; muscle of thigh; ; body of tongue; ; vastus lateralis muscle; ; triceps brachii muscle; ; left ventricle; ; skeletal muscle tissue; ; glutes; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	right ventricle; ; right kidney; ; myocardium of ventricle; ; cardiac muscle tissue of left ventricle; ; atrium; ; plantaris muscle; ; soleus muscle; ; atrioventricular valve; ; thoracic diaphragm; ; otic vesicle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; oxidoreductase activity; isocitrate dehydrogenase activity; NAD binding; magnesium ion binding; metal ion binding; isocitrate dehydrogenase (NADP+) activity; protein homodimerization activity;
Cellular component	mitochondrial inner membrane; cytosol; mitochondrial matrix; peroxisome; extracellular exosome; mitochondrion;
Biological process	2-oxoglutarate metabolic process; glyoxylate cycle; isocitrate metabolic process; tricarboxylic acid cycle; NADP biosynthetic process; negative regulation of glial cell proliferation; negative regulation of glial cell migration; negative regulation of matrix metallopeptidase secretion; mitochondrion organization; carbohydrate metabolic process; NADP metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	3418
	269951
	ENSG00000182054
	ENSMUSG00000030541
	P48735
	P54071
	NM_002168; NM_001289910; NM_001290114
	NM_173011
	NP_001276839; NP_001277043; NP_002159
	NP_766599
	Wikidata
View/Edit Human	View/Edit Mouse

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Revision as of 22:09, 10 February 2008

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Isocitrate dehydrogenase 2 (NADP+), mitochondrial, also known as IDH2, is a human gene.^[5]

Isocitrate dehydrogenases are enzymes that catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by the IDH2 gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182054 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030541 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial".

@@ Line 63: / Line 63: @@
 * {{cite journal  | author=Chamberlain KG, Penington DG |title=Monoamine oxidase and other mitochondrial enzymes in density subpopulations of human platelets. |journal=Thromb. Haemost. |volume=59 |issue= 1 |pages= 29-33 |year= 1988 |pmid= 3363531 |doi=  }}
 * {{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
-* {{cite journal  | author=Luo H, Shan X, Wu J |title=Expression of human mitochondrial NADP-dependent isocitrate dehydrogenase during lymphocyte activation. |journal=J. Cell. Biochem. |volume=60 |issue= 4 |pages= 495-507 |year= 1996 |pmid= 8707889}}
+* {{cite journal | author = Luo H, Shan X, Wu J | title = Expression of human mitochondrial NADP-dependent isocitrate dehydrogenase during lymphocyte activation | journal = J. Cell. Biochem. | volume = 60 | issue = 4 | pages = 495–507 | year = 1996 | pmid = 8707889 | doi = 10.1002/(SICI)1097-4644(19960315)60:4%3C495::AID-JCB6%3E3.0.CO;2-N | issn = }}
 * {{cite journal  | author=Oh IU, Inazawa J, Kim YO, ''et al.'' |title=Assignment of the human mitochondrial NADP(+)-specific isocitrate dehydrogenase (IDH2) gene to 15q26.1 by in situ hybridization. |journal=Genomics |volume=38 |issue= 1 |pages= 104-6 |year= 1997 |pmid= 8954790 |doi= 10.1006/geno.1996.0602 }}
 * {{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}

Revision as of 22:09, 10 February 2008

References

Further reading