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==References==
==References==
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<references/>
<ref>[http://whoguideline.blogspot.com
== [[Pharmaceutical Regulatory affairs and GMP]] ==
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==External links==
==External links==

Revision as of 16:32, 3 November 2009

Imam Khomeini hospital

Health care in Iran and medical sector's market value was almost US $24 billion in 2002 and was forecast to rise to US $31 billion by 2007.[1] With a population of almost 70 million, Iran is one of the most populous countries in the Middle East. The country faces the common problem of other young demographic nations in the region, which is keeping pace with growth of an already huge demand for various public services. The young population will soon be old enough to start new families, which will boost the population growth rate and subsequently the need for public health infrastructures and services. Total healthcare spending is expected to rise from US$24.3bn in 2008, to US$50.0bn by 2013, reflecting the increasing demand on medical services.[2] Total health spending was equivalent to 4.2% of GDP in Iran in 2005.[3] 73% of all Iranians have health care coverage.[3]

The World Health Organization in the last report on health systems ranks Iran's performance on health level 58th, and its overall health system performance 93rd among the world's nations.[4] The health status of Iranians has improved over the last two decades. Iran has been able to extend public health preventive services through the establishment of an extensive Primary Health Care Network.[5] As a result child and maternal mortality rates have fallen significantly, and life expectancy at birth has risen remarkably. Infant (IMR) and under-five (U5MR) mortality have decreased to 28.6 and 35.6 per 1,000 live births respectively in 2000, compared to an IMR of 122 per 1,000 and a U5MR of 191 per 1,000 in 1970. [6] Immunization of children is accessible to most of the urban and rural population.[3]

Health services

IRAN: Healthcare (Source: EIU)[3] 2005 2006 2007
Life expectancy, average (years) 70.0 70.3 70.6
Healthcare spending (% of GDP) 4.2 4.2 4.2
Healthcare spending (US$ per head) 113 132 150

The constitution entitles Iranians to basic health care, and most receive subsidized prescription drugs and vaccination programs. An extensive network of public clinics offers basic care at low cost, and general and specialty hospitals operated by the Ministry of Health and Medical Education (MOHME) provide higher levels of care. In most large cities, well-to-do persons use private clinics and hospitals that charge high fees.[3] About 73% of all Iranian workers have social security coverage. In 2000, 94% of the population could access local health services, according to the WHO. Access ranged from 86% in rural areas to 100% in urban areas.[3] Between 80% and 94% of the population could access affordable essential medicines in 1999.[3]

Iran has been very successful in training/educating the necessary human resources for its health system. The system of almost 30 years ago where the country was facing a shortage of all kinds of skilled personnel in the health and medical sector has been completely changed into one in which the necessary professionals now completely suffice the country’s needs. There are now 488 government funded hospitals in Iran. There were 0.5-1.1 physicians per 1000 population in 2004 according to various estimates (about 46 percent of physicians were women).[7]

Although overall improvements have been achieved in all health areas since the 1979 revolution, the present challenging economic conditions of the country, combined with rapid advances in medical technology and information technology, individuals’ expectations, and the young demographic of the population will undoubtedly challenge the sustainability of past improving trends. Moreover there is a considerable variation in the human development index and the human poverty index across different provinces in the country. Iran will invest 2.5 billion dollars in the country's stem cell research over the next five years (2008-2013).[8]

Health network

Shariati Hospital in Tehran

Today the largest healthcare delivery network is owned and run by the Ministry of Health and Medical Education (MOHME) through its network of health establishments and medical schools in the country. MOHME is in charge of provision of healthcare services through its network, medical insurance, medical education, supervision and regulation of the healthcare system in the country, policymaking, production and distribution of pharmaceuticals, and research and development. Additionally, there are other parallel organisations such as Medical Services Insurance Organizations (MSIO) that have been established to act as a relief foundation as well as an insurance firm. Some hospitals, such as Mahak for childrens cancer, are run by charitable foundations.

According to the last census that Statistical Centre of Iran undertook in 2003, Iran possesses 730 medical establishments (eg. hospitals, clinics) with a total of 110,797 beds, of which 488 (77,300 beds) are directly affiliated and run by the MOHME and 120 (11,301 beds) owned by the private sector and the rest belong to other organisations, such as the Social Security Organization of Iran (SSO). There were about seven nurses and 17 hospital beds per 10,000 population.[3]

An elaborate system of health network has been established which has ensured provision of Primary Health Care (PHC) to the vast majority of public. However, access and availability of health care continues to be somewhat limited in lesser developed provinces where the health indices are also lower as compared to national averages. The country is in an epidemiologic transition and faces double burden of the diseases. New emerging threats should also be considered. The demographic and epidemiological transition underway will have a significant effect on the pattern of morbidity and mortality in the near and distance future, especially as it affects the emergence of chronic non-communicable diseases and the health problems of an aging population. In the early 2000s the main natural causes of death have been cardiovascular disease and cancer.

Water and sanitation

Iran has one of the highest percentages of population in the Middle East with access to safe drinking water, with an esimated 92% of its people enjoying such access (nearly 100% in urban areas and about 80% in rural areas as of 2007).[9][10]

There is a considerable shortfall in wastewater treatment; for example, in Tehran the majority of the population has no wastewater treatment, with raw sewage being injected directly into the groundwater[11]. As the water crisis deepens with an expanding population, this pollution of groundwater causes increasing health risks.

Nutrition

Despite the fact that Iran consists of an agrarian economy, there is a high degree of malnutrition within the country. Approximately one fourth of all young children have stunted or wasted growth characteristics due to undernourishment [12]; moreover, as an indicator of the poor food distribution capability, the percentage of undernourished children in villages is much higher. As an additional measure of public health and inefficient food distribution, about thirteen percent of the young people are classified as obese, according to the same United Nations FAO sources.

The soft drinks industry is valued at about $2 billion a year. Today, Iran produces about 3 billion litters of different types of soft drinks to address consumption per capita of 46 litters, and export more than 12% of its production. Increased awareness with regards to the damages of carbonated drinks and sugar, and high levels of diabetes has created a move towards healthier products.[13]

Communicable diseases & drugs

Cholera: has been a persistent problem in Iran. In the 2005 epidemic which involved loss of lives, state television warned people not to eat vegetables or buy ice blocks on the streets [14]. Salads were also banned in some restaurants. The 1998 epidemic involved considerably more cases and loss of life.

HIV/AIDS: Increased drug use has driven up the incidence of human immunodeficiency virus (HIV). In 2005 two-thirds of the official total of 9,800 HIV cases were attributed to drug use. Iran has established a national HIV treatment system, including 150 testing sites and a free needle exchange program [15]. Addiction is the fourth major cause of death in Iran following road accidents, heart disease and depression.[16]

According to the United Nations, AIDS has been increasing in Iran at a rapid rate [17]. The major factor fuelling the epidemic until now has been injecting drug use, while there is an increase in sexual transmission of the disease." The rate of the epidemic in Iran is however still very low compared to international standards. Iran has a low prevalence of HIV infections with a rate of about 0.16 percent of the adult population (18,000 cases) compared with 0.8 percent in North America (2008).[18]

Illegal drugs: Iran is situated along one of the main trafficking routes for cannabis, heroin, opium and morphine produced in Afghanistan, and designer drugs have also found their way into the local market in recent years. Hundreds of drug production laboratories have been set up in Pakistan and Afghanistan.[19] Iran's police said in April 2009 that 7,700 tonnes of opium was produced in Afghanistan in 2008, of which 3000 tonnes entered Iran, adding that the force had managed to seize 1000 tonnes of the smuggled opium.[20] Drug addiction constitutes a major health problem. Iran spent over 600 million dollars in just the last two years to dig canals, build barriers and install barbed wire to seal off the country’s crime-infested borders.[21] Iran discovers 3 tons of drugs daily (2008).[22] In 2005, estimates of the number of drug addicts ranged from 2 to 4 million (1.2 million according to the Government) [23]. Reasons for addiction include lack of economic prospects among the youth and lack of freedom. 40% of prisoners in Iran have been convicted on drug related charges.[24] According to published figures, Iran has so far lost close to 3,500 police and security officers to the anti-drug campaign that annually costs the country almost $1 billion.[25]

Smoking: Iran has implemented a strict smoking ban in all public places (2007). According to the new law, smoking is prohibited in all public organizations, hotels, restaurants, tea houses and coffee shops. Also forbidden is the offering and smoking of the traditional Persian waterpipe which is a must in Iranian tea houses. A smoking ban for all car drivers nationwide was implemented since March 2006, and although offenders could face fines up to 14 US dollars, the ban was widely ignored by the drivers. Also selling tobacco products to anyone under 18 would result in confiscation of the vendor's tobacco products and a cash fine up to 65 dollars. Repeated violations would lead to cash fines amounting to 1,400 dollars.

About 20% of adult male and 4.5% of adult female population in the country smoke tobacco (12 million smokers according to some estimates).[26][27] 60,000 Iranians die directly or indirectly due to smoking every year (2008).[28] Smoking is responsible for 25% of death in the country.[29] Approx. 54bn cigarettes are believed to be consumed annually in Iran. Around 2.7bn cigarettes are smuggled into Iran annually, according to officials from the state-owned Iranian Tobacco Company (ITC), on top of another 26.7bn which are imported legally (2008).[30]

Air pollution: The prevalence of respiratory diseases and cancers in Iran is increasing at a significant rate, also because of air pollution in Tehran.[2]

Alcohol: Prohibited in Iran because of the Islamic law, except for non-Muslims who can legally consume alcoholic beverages in private.

Pharmaceuticals

Iran has a rather developed pharmaceutical production capability, however, the country still relies on imports for raw materials and many specialised drugs.

Iran’s Ministry of Health and Medical Education (MOHME) has a mission to provide access to sufficient quantities of safe, effective and high quality medicines that are affordable for the entire population. Since the 1979 revolution, Iran has adopted a full generic-based National Drug Policy (NDP), with local production of essential drugs and vaccines as one of the main goals. [31].

In 2006, 55 pharmaceutical companies in Iran produce more than 96 percent (quantitatively) of medicines on the market, worth $1.2 billion annually[32]. Iran’s pharmaceutical market is estimated to be worth $1.87 billion (2008) and $3.65bn by 2013 (projected).[33][34] Although over 85 percent of the population use an insurance system to reimburse their drug expenses, the government heavily subsidises pharmaceutical production/importation in order to increase affordability of medicines. The regulatory environment of the country is rather strict on the import of drugs and pharmaceuticals towards companies that intend to enter into the market for the first time. The Ministry of Health and Medical Education is the main stakeholder of pharmaceutical affairs in the country. The Social Security Investment Co. (SSIC), Iran's largest holding company, which is affiliated to the Ministry of Welfare, presently owns and controls 22 pharmaceutical manufacturing companies and possesses a 40% share of total pharmaceutical production in Iran.[35]

The market share of local production (value-wise) has declined from 85.2% to 63.4% over the past 8 (Iranian) years (2009). In this period the value of importation has jumped from 14.8% to 36.6%.[36]

The leading pharmaceuticals company is Darou Pakhsh, which is majority-owned by the Social Security Organization. The company manufactures, distributes, imports and exports finished products and pharmaceutical raw materials. Darou Pakhsh has an annual turnover of US$400m and claims to have the largest research and development operation of any Iranian drug firm. The company formed a plasmapheresis joint venture with a German medical firm, Biotest AG, in early 2004.[3]

Other major pharma or biotech companies in Iran are Pars Darou, Iran Pharmaceutical Development & Investment Co. (IPDIC), Pharmieco, and CinnaGen. Asia Dava Tech, Behdaru, Actover Co. and Cobel Darou are also active players in this market.[citation needed]

The new drugs launched in Iran for the treatment of MS are believed to include an interferon beta-1b by CinnaGen. A generic version of fingolimod by Novartis has been launched as well as a biosimilar version of EMD Serono′s Rebif.[37] Iranian pharmaceutical manufacturers are disadvantaged by the government′s poor intellectual property protection regime and because of lack of foreign direct investment.[2]

More than 2,000 plant species are grown in Iran; only 100 of which are being used in pharmaceutical industries.[38]

Medical equipment

The Department of Medical Equipments in the Ministry of Health and Medical Education (MOHME) is responsible for supervising imports in this segment, but the import and distribution of such equipment is mostly handled by the private sector. Iran has undergone the primary stages of development in terms of industrialisation and a rather strong indigenous manufacturing capability exists in the country. Therefore one can expect to find a handful of local producers for basic medical equipment, making it very hard to penetrate into the Iranian market for similar imported ones. 'Iran MED' and 'Iran LAB' are the main annual exhibitions relating to medical and laboratory equipments in Tehran.[39]

There are over 100 Iranian companies representing the international suppliers in this market, handling both promotion and the after-sales service of the products. Iran is a mature market when it comes to medical equipment. Most of the major international players in this sector are present in the Iran market (American sanctions against Iran do not apply to medical equipment or pharmaceuticals):

See also

References

  1. ^ Health services and pharmaceuticals to Iran - For Australian exporters - Austrade
  2. ^ a b c http://www.payvand.com/news/09/apr/1027.html
  3. ^ a b c d e f g h i "IRAN: Healthcare and Pharmaceuticals Forecast", Economist Intelligence Unit, August 18, 2008 {{citation}}: |access-date= requires |url= (help); Cite has empty unknown parameters: |coeditors= and |coauthors= (help)
  4. ^ WHO, World Health Organisation. "The World Health Report 2000" (PDF). Retrieved 2006-10-12. {{cite web}}: Check |first= value (help)
  5. ^ http://www.iran-daily.com/1388/3439/html/economy.htm#s390000
  6. ^ UNICEF - At a glance: Iran (Islamic Republic of) - The big picture
  7. ^ http://www3.who.int/whosis/core/core_select_process.cfm?country=irn&indicators=healthpersonnel&intYear_select=all&language=en
  8. ^ http://www.payvand.com/news/08/nov/1059.html
  9. ^ http://www.unicef.org/specialsession/about/sgreport-pdf/03_SafeDrinkingWater_D7341Insert_English.pdf
  10. ^ Iran_islamic_rep_of_04.xls
  11. ^ [1]
  12. ^ Nutrition country profiles: Iran summary
  13. ^ http://www.atiehbahar.com/Resource.aspx?n=1000011
  14. ^ Iran cholera outbreak takes more life, mullahs' regime clueless - Persian Journal Iran news, Latest iran news Iranian newspaper women zan
  15. ^ Country profile - US library of Congress
  16. ^ http://www2.irna.ir/en/news/view/menu-234/0810278680174556.htm
  17. ^ Countries
  18. ^ http://www.reuters.com/article/lifestyleMolt/idUSTRE4AO44O20081125
  19. ^ http://www.iran-daily.com/1388/3435/html/society.htm#s388974
  20. ^ http://www.news.com.au/perthnow/story/0,21498,25451098-5005361,00.html?from=public_rss
  21. ^ http://www.iran-daily.com/1387/3262/html/national.htm
  22. ^ http://www.payvand.com/news/08/nov/1156.html
  23. ^ http://www.unodc.org/pdf/afg/afg_drug-situation_2002-10-01_1.pdf
  24. ^ http://www.iran-daily.com/1388/3435/html/society.htm#s388974
  25. ^ http://www.iran-daily.com/1387/3275/html/national.htm
  26. ^ http://www2.irna.ir/en/news/view/menu-235/0812241246201050.htm
  27. ^ http://www.payvand.com/news/09/jun/1006.html
  28. ^ http://www.smokersclubinc.com/modules.php?name=News&file=article&sid=1834
  29. ^ http://www.payvand.com/news/09/jun/1006.html
  30. ^ "IRAN: Food, Beverages and Tobacco Forecast", Economist Intelligence Unit, August 18, 2008 {{citation}}: |access-date= requires |url= (help); Cite has empty unknown parameters: |coeditors= and |coauthors= (help)
  31. ^ Iran-Daily: Biggest Pharmaceutical Plant to Open Soon
  32. ^ Iran Daily - National - 07/01/07
  33. ^ http://www.iran-daily.com/1387/3249/html/economy.htm
  34. ^ [2]
  35. ^ http://www.atiehbahar.com/Resource.aspx?n=1000012
  36. ^ http://iran-pharma.blogspot.com/2008_12_10_archive.html
  37. ^ http://www.presstv.com/detail.aspx?id=90441&sectionid=3510210
  38. ^ Iran’s share of worldwide medicinal plant trade barely 2%
  39. ^ http://www.iran-daily.com/1388/3421/html/science.htm#s385215

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