Journal of Clinical Investigation

Journal of Clinical Investigation

Discipline	Biomedicine
Language	English
Edited by	Howard A. Rockman
Publication details
History	1924-present
Publisher	American Society for Clinical Investigation (United States)
Frequency	Monthly; articles published weekly online
Open access	Yes
Impact factor	12.812 (2012)
Standard abbreviations ISO 4 (alt) · Bluebook (alt1 · alt2) NLM (alt) · MathSciNet (alt )
ISO 4	J. Clin. Invest.
Indexing CODEN (alt · alt2) · JSTOR (alt) · LCCN (alt) MIAR · NLM (alt) · Scopus
CODEN	JCINAO
ISSN	0021-9738 (print) 1558-8238 (web)
LCCN	27010044
OCLC no.	01445593
Links
Journal homepage Online access Online archive

The Journal of Clinical Investigation (JCI) is a peer-reviewed medical journal published by the American Society for Clinical Investigation (ASCI).

Evaluation and peer review of research

The JCI receives submissions from authors worldwide. Unlike at most commercial journals, an Editorial Board made up of scientists actively engaged in scientific discovery rigorously evaluates each submitted article for scientific merit to determine its suitability for the JCI. Submitted manuscripts are sent out for external peer review if the board member with specific expertise in the subject area handling the manuscript believes it represents a substantial conceptual advance and is appropriate for the broad readership of the JCI. The JCI strives for timely and thoughtful decisions on manuscripts that incorporate the recommendations from peer review and the discussion at the weekly Editorial Board meeting.

Scope

Research articles focus on the mechanisms of disease, with an emphasis on basic research, early-stage clinical studies in humans, and new research tools and techniques. The JCI also publishes scientific reviews in edited series or as stand-alone articles, commentaries on research articles, personal perspectives, editorials, and news and feature items. A companion to the journal, JCI Impact, launched in January 2013, summarizes and highlights the content of each month's issue.

Current Editorial Board

The Editorial Board comprises scientists associated with an academic medical center, which changes every five years, allowing for new editorial perspectives and areas of expertise. Since 2012, the journal has been headed by Editor in Chief Dr. Howard A. Rockman and an Editorial Board of peer scientists at Duke University Medical Center, the University of North Carolina, Duke-NUS, and the Sanford-Burnham Medical Research Institute.

Influential research

The top-cited JCI articles as of July 2013, according to Scopus

Title	Year published	No. of citations
The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum	1955	2,529
Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria	1973	3,514
An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels	1990	2,416
Role of oxidized low density lipoprotein in atherogenesis	1991	1,813
Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques	1994	1,605
Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance	1995	1,794
Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone	1996	1,655
Role of AMP-activated protein kinase in mechanism of metformin action	2001	1,763
Obesity is associated with macrophage accumulation in adipose tissue	2003	2,840
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance	2003	2,124

Business model

The JCI is a nonprofit publication of the ASCI, with a publishing office in Ann Arbor, Michigan. All JCI research articles are freely available online upon publication. Revenue derives from submission fees, which support maintenance of an Editorial Board; page charges to authors for published articles; and subscription fees, which apply in the case of most non-research articles. The JCI deposits all articles in PubMed Central; however, most non-research articles are embargoed for release by PubMed Central until the start of the year after the year in which those articles are published.

History of the Journal of Clinical Investigation

The JCI was established by the ASCI in 1924 to serve as the major U.S. venue for research on disease and clinical medicine. A publication of the American Society for Clinical Investigation, the journal initially received financial backing from the Rockefeller Institute for Medical Research (now known as Rockefeller University. The journal then turned to a model based on individual and university clinic subscriptions. At a time of financial struggles during the Great Depression, the Chemical Foundation ran the JCI (1931–1940). Page charges were instituted in 1965 to offset publication costs. Rockefeller University Press published the journal from 1967 until 1999. Since that time, the ASCI has published the JCI. In 1996 the JCI became the first major scientific journal to make its content available barrier-free online.

Several articles focus on the history of the journal:

• Brainard ER. History of the Journal of Clinical Investigation, 1924–1959. I. Personnel and policies. J Clin Invest. 1959;38(10 pt 1–2): 1865–1872. dx.doi.org/10.1172/JCI103962
• Bondy PK. History of the Journal of Clinical Investigation, 1924–1959. I. Scientific contents. J Clin Invest. 1959;38(10 pt 1–2):1873–1877.
• Savla U. Reflecting on 80 years of excellence. J Clin Invest. 2004;114(8):1006–1016.
• Howell JD. A history of the American Society for Clinical Investigation. J Clin Invest. 2009;119(4):682–697.

Editors of the Journal of Clinical Investigation

Name	Tenure	Affiliation
G. Canby Robinson	1924–1927	Vanderbilt University
J. Harold Austin	1928–1934	University of Pennsylvania
Randolph West	1935–1940	Presbyterian Hospital (New York)
James L. Gamble	1941–1946	Harvard University
Eugene B. Ferris	1947–1951	Cincinnati General Hospital
Stanley E. Bradley	1952–1956	Columbia University
Philip K. Bondy	1957–1961	Yale University
Arnold S. Relman	1962–1966	Harvard University
Paul A. Marks	1967–1970	Columbia University
DeWitt S. Goodman	1971–1972	Columbia University
Jean D. Wilson	1972–1977	University of Texas Southwestern Medical Center
Philip W. Majerus	1977–1981	Washington University
Stuart Kornfeld	1981–1982	Washington University
Thomas P. Stossel	1982–1985	Harvard University
Joseph Avruch	1986–1987	Harvard University
Bruce F. Scharschmidt	1987–1992	University of California–San Francisco
Ajit P. Varki	1992–1996	University of California–San Diego
Paul A. Insel	1996–1997	University of California–San Diego
Martin F. Kagnoff	1996–1997	University of California­–San Diego
Stephen J. Weiss	1997–2002	University of Michigan
Andrew R. Marks	2002 2007	Columbia University
Laurence A. Turka	2007–2012	University of Pennsylvania
Howard A. Rockman	2012–present	Duke University

External links

• JCI website
• JCI online archive
• JCI Editorial Board
• JCI article submission site
• JCI Impact
• ASCI website