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{{POV|This article reeks of VSCA, especially given recent controversy of Dr. Oz's senate testimony|date=June 2014}}
#redirect[[Green coffee extract]]
{{unreliable sources|date=June 2014}}
{{notability|Products|date=June 2014}}
'''Svetol''' is a proprietary standardized [[chlorogenic acid]] extract of [[decaffeinate]]d [[green coffee bean]]s, sold by [[:fr:Naturex|Naturex]]. It is used as a weight-loss supplement and as an ingredient in other weight-loss products. Svetol has been on the market as a dietary supplement since 2002,<ref name=science>Halliday, Jess. [http://www.nutraingredients.com/Industry/Berkem-talks-science-to-take-Svetol-into-foods "Berkem Talks Science to Take Svetol into Foods"]. ''Nutra Ingredients''. December 6, 2006.</ref> and its efficacy and mechanism of action have been clinically tested.<ref name=science />

Svetol is a hydroalcoholic decaffeinated [[green coffee extract]] produced from coffee beans of the variety ''Coffea canephora robusta'' Pierre. The extract is [[Spray drying|spray dried]] and encapsulated.<ref name=farah>{{cite journal|last=Farah|first=A.|coauthors=Monteiro, M.; Donangelo, C.; Lafay, S.|title=Chlorogenic Acids from Green Coffee Extract are Highly Bioavailable in Humans|journal=[[Journal of Nutrition]].|year=2008|issue=138|pages=2309–2315|doi=10.3945/jn.108.095554|url=http://jn.nutrition.org/content/138/12/2309.full.pdf}}</ref> Svetol contains a specific chlorogenic acids profile balanced between 3-, 4-, and 5-caffeoylquinic acid, and contains 45%–50% chlorogenic acids by weight.<ref name=thom /><ref name=svetol>[http://www.naturex.com/data/classes/docu_fichier/docu_fichier_13_30.pdf Svetol – Fact sheet]</ref>

==History==
Svetol was developed by Berkem, a French [[phytochemical]] and [[plant extract]] company. The product was first marketed as a dietary supplement in 2002.<ref name=science /> By 2005 it was the active ingredient in CoffeeSlender, a popular weight-loss product in Norway, and the product launched in the UK the following year.<ref>Halliday, Jess and Chris Mercer. [http://www.beveragedaily.com/R-D/Slimming-coffee-to-launch-in-UK "Slimming Coffee to Launch in UK"]. ''BeverageDaily.com''. December 6, 2006.</ref> At the 2006 Health Ingredients Europe conference, boosted by recently published clinical-study findings on Svetol's weight-loss efficacy, it received the Bronze Award in the best ingredient category.<ref>[http://www.naturalproductsinsider.com/news/2007/01/nutraceutical-industry-news-briefs.aspx "Berkem’s Svetol Receives Bronze Award"]. ''Natural Products Insider''. January 15, 2007.</ref><ref name=science />

In January 2008, [[:fr:Naturex|Naturex]], an international natural ingredient manufacturer, acquired Berkem's clinically tested plant extract division, of which a prime product was Svetol.<ref>[http://www.actusnews.com/communique.php?ID=ACTUS-0-11225 "Naturex Acquires Berkem’s 'Actifs Innovants' Division"]. ''ActusNewsWire''. January 8, 2008.</ref><ref name=buys>Halliday, Jess. [http://www.nutraingredients.com/Industry/Naturex-buys-Berkem-s-Actifs-Innovants "Naturex Buys Berkem's Actifs Innovants"]. ''Nutra Ingredients''. January 8, 2008.</ref><ref> Voinchet, Alexandra. [http://www.francebourse.com/fiche_news_22381.fb "Naturex : Des acquisitions porteuses"]. ''France Bourse''. January 17, 2008.</ref> The acquisition by the larger company boosted the marketing force behind the product,<ref name=buys /> and Naturex brought Svetol to the U.S. market.<ref>Heller, Lorraine. [http://www.nutraingredients-usa.com/Suppliers2/Naturex-brings-weight-loss-ingredient-to-US-foods "Naturex Brings Weight Loss Ingredient to US Foods"]. ''Nutra Ingredients''. January 14, 2008.</ref> Also in 2008, the division of the joint company completed and published a review of studies investigating Svetol's efficacy, mechanism of action, and bioavailability.<ref>[http://business.highbeam.com/409195/article-1G1-175343761/naturex-reviews-fat-burning-data-svetol "Naturex reviews fat burning data on Svetol"]. ''Nutraceuticals International''. February 1, 2008.</ref>

In April and September 2012, ''[[The Dr. Oz Show]]'' featured [[green coffee extract]], and conducted its own placebo-controlled study as to its efficacy. [[Dr. Oz]] specifically recommended either Svetol or GCA as the green coffee extract brands to assist with weight-loss goals.<ref>[http://www.doctoroz.com/videos/green-coffee-bean-extract-fat-burner-or-fraud-pt-5 "Green Coffee Bean Extract: Fat-Burner or Fraud? Pt 5"]. ''[[The Dr. Oz Show]]''. September 2012.</ref><ref>[http://www.doctoroz.com/videos/green-coffee-bean-project "The Green Coffee Bean Project"]. ''[[The Dr. Oz Show]]''. September 6, 2012.</ref><ref>[http://www.doctoroz.com/videos/fact-sheet-green-coffee-bean "Fact Sheet: Green Coffee Bean"]. ''[[The Dr. Oz Show]]''. April 26, 2012.</ref><ref>Carson, Ralph E. [http://www.fitrxbrentwood.com/dr-oz-green-coffee-bean-extract/ "Dr. Oz Promotes the Green Coffee Bean".] ''FitRx''. July 24, 2013.</ref> As of 2013, Svetol has increasingly been cited as one of the two brands of green coffee extract that is standardized to contain at least 45% [[chlorogenic acid]],<ref>Pepper, Leslie. [http://books.google.com/books?id=gQFBcKwBrrIC&pg=PA24 ''The Green Coffee Bean Quick Weight Loss Diet'']. Macmillan, 2013. p. 24.</ref><ref>Ripenburg, Patricia. [http://books.google.com/books?id=2thDrqcja-4C&pg=PA107 ''Food Can Improve Your Health'']. Trafford Publishing, 2013. p. 107.</ref> and as the brand of choice for green coffee extract supplementation.<ref>Bagchi, Debasis and Harry G. Preus. [http://books.google.com/books?id=pvE3I22KhNoC&pg=PA489 ''Obesity: Epidemiology, Pathophysiology, and Prevention'']. CRC Press, 2012. p. 489.</ref> In 2013 EuroPharma added Svetol to its line, stating that it shows "some of the most impressive clinical data available".<ref>Barbanel, Shari. [http://digitaledition.qwinc.com/display_article.php?id=1325709 "Weighing Options"]. ''Vitamin Retailer''. March 2013.</ref> As of 2013, Svetol is the number one slimming ingredient in the U.S., and is used in 100 co-branded products in North America.<ref>''Engredea News & Analysis''. [http://newhope360.com/botanicals/svetol-comes-europe "Svetol Comes to Europe"]. ''New Hope 360''.
May 13, 2013.</ref>

==Clinical studies and mechanism of action==
In a study published in 2006 in ''Phytothérapie'', a randomized, placebo-controlled clinical trial used a group of 50 overweight volunteers to test Svetol over the course of 60 days. Subjects receiving Svetol showed significant decrease of weight, body mass index, and fat mass.<ref name=phyto>{{cite journal|last=Dellalibera|first= O.|coauthors=Lemaire, B., Lafay, S.|title=Svetol®, green coffee extract, induces weight loss and increases the lean to fat mass ratio in volunteers with overweight problem|journal=Phytothérapie|date=November 2006|volume=4|issue=4|pages=194-197|doi=10.1007/s10298-006-0181-7|url=http://www.realdose.com/wp-content/uploads/2012/01/Effect_of_Svetol_on_weight_loss_on_humans.pdf}}</ref> In a 2007 report published in ''AgroFOOD Industry Hi-Tech'', studies carried out on Svetol's efficacy and
mechanism of action were reviewed, including two clinical trials and an in vitro study. The report concluded that "Svetol has demonstrated its validity and could be used to aid the recommended [bland low caloric] diet in a useful and positive manner."<ref name=agro>{{cite journal|last=Nardon|first=K.|coauthors=Lemaire, B.; Lafay, S.|title=Green coffee extract Svetol® can manage weight: a review|journal=AgroFOOD Industry Hi-Tech.|date=September–October 2007|volume=18|issue=5|pages=37-39|url=http://www.docstoc.com/docs/28127159/Green-coffee-extract-Svetol-can-manage-weight-a-review}}</ref> The report also concluded that Svetol works as a fat burner to reduce body mass index and increase the lean mass to fat mass ratio via two mechanisms of action: by decreasing intestinal absorption of glucose and also by inhibiting [[glucose-6-phosphatase]] in the liver.<ref name=agro /><ref>[http://business.highbeam.com/392465/article-1G1-181991835/svetolr "Svetol: Review"]. ''Functional Foods and Nutraceuticals''. May 1, 2008.</ref> A study published in 2007 in the ''Journal of International Medical Research'' detailed two randomized clinical studies which measured the effects on glucose absorption and body mass of a coffee product whose active component was Svetol. The study concluded that Svetol has a significant effect on the absorption and utilization of dietary glucose, and if used for an extended time can result in reduced body mass and body fat.<ref name=thom>{{cite journal|last=Thom|first=Erling|title=The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people.|journal=Journal of International Medical Research|date=November–December 2007|volume=35|issue=6|pages=900-908|pmid=18035001|url=https://coffee12.s3.amazonaws.com/The_Effect_of_Chlorogenic_Acid_Enriched_Coffee.pdf|accessdate=}}</ref>

A 2010 in vitro study detailed in the ''[[Journal of Agricultural and Food Chemistry]]'' showed that Svetol significantly inhibited [[glucose 6-phosphate]] hydrolysis in intact human liver microsomes in a competitive manner, and that this inhibition by Svetol contributes to its [[antidiabetic]], glucose-lowering effects by reducing hepatic glucose production.<ref>{{cite journal|last=Henry-Vitrac|first=C.|coauthors=Ibarra A.; Roller M.; Mérillon J-M.; Vitrac X.|title=Contribution of chlorogenic acids to the inhibition of human hepatic glucose-6-phosphatase activity in vitro by Svetol, a standardized decaffeinated green coffee extract.|journal=[[Journal of Agricultural and Food Chemistry]].|year=2010|volume=58|issue=7|pages=4141–4144|doi=10.1021/jf9044827|pmid=20302380}}</ref> An overview of randomized clinical trials published in 2011 in ''Gastroenterology Research and Practice'' reiterated that intake of Svetol can promote weight loss.<ref name=onakpoya>{{cite journal|last=Onakpoya|first=I.|coauthors=Terry, R.; Ernst, E.|title=The Use of Green Coffee Extract as a Weight Loss Supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials|journal=Gastroenterology Research and Practice.|year=2011|volume=2011|doi=10.1155/2011/382852|url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943088/?report=classic}}</ref> In a 2012 study using mice, published in ''Nutritional Neuroscience'', Svetol's effect on [[insulin resistance]] and brain energy metabolism was investigated. Svetol significantly attenuated the development of high-fat diet-induced deficits in [[glucose tolerance|glucose-tolerance]] response; it also improved brain [[mitochondria]]l energy metabolism, and modulated a number of genes in the brain that are implicated in cellular energy metabolism.<ref name=ho>{{cite journal|last=Ho|first=L.|coauthors=Varghese M.; Wang J.; Zhao W.; Chen F.; et al.|title=Dietary supplementation with decaffeinated green coffee improves diet-induced insulin resistance and brain energy metabolism in mice.|journal=Nutritional Neuroscience.|date=January 2012|volume=15|issue=1|pages=37-45|doi=10.1179/1476830511Y.0000000027|pmid=22305652}}</ref> And a 2013 study published in ''[[Phytotherapy Research]]'' determined that longterm Svetol use has a [[lipolytic]] activity unrelated to possible trace amounts of caffeine; the study concluded that the release of [[free fatty acids]] from [[adipose tissue]] from longterm Svetol use is due to Svetol's chlorogenic acid action.<ref>{{cite journal|last=Flanagan|first=J.|coauthors=Bily, A.; Rolland Y.; Roller, M.|date=December 12, 2013|title=Lipolytic activity of Svetol®, a decaffeinated green coffee bean extract|journal=[[Phytotherapy Research]]|doi=10.1002/ptr.5085}}</ref>

==References==
{{reflist|2}}

==External links==
*[http://www.svetol.com Official site]

[[Category:Brand name diet products]]
[[Category:Management of obesity]]
[[Category:Polyphenol-enriched extracts]]
[[Category:Botanical extracts]]
[[Category:Dietary supplements]]
[[Category:Phytochemicals]]
[[Category:Dietary antioxidants]]

Revision as of 06:33, 24 June 2014

Svetol is a proprietary standardized chlorogenic acid extract of decaffeinated green coffee beans, sold by Naturex. It is used as a weight-loss supplement and as an ingredient in other weight-loss products. Svetol has been on the market as a dietary supplement since 2002,[1] and its efficacy and mechanism of action have been clinically tested.[1]

Svetol is a hydroalcoholic decaffeinated green coffee extract produced from coffee beans of the variety Coffea canephora robusta Pierre. The extract is spray dried and encapsulated.[2] Svetol contains a specific chlorogenic acids profile balanced between 3-, 4-, and 5-caffeoylquinic acid, and contains 45%–50% chlorogenic acids by weight.[3][4]

History

Svetol was developed by Berkem, a French phytochemical and plant extract company. The product was first marketed as a dietary supplement in 2002.[1] By 2005 it was the active ingredient in CoffeeSlender, a popular weight-loss product in Norway, and the product launched in the UK the following year.[5] At the 2006 Health Ingredients Europe conference, boosted by recently published clinical-study findings on Svetol's weight-loss efficacy, it received the Bronze Award in the best ingredient category.[6][1]

In January 2008, Naturex, an international natural ingredient manufacturer, acquired Berkem's clinically tested plant extract division, of which a prime product was Svetol.[7][8][9] The acquisition by the larger company boosted the marketing force behind the product,[8] and Naturex brought Svetol to the U.S. market.[10] Also in 2008, the division of the joint company completed and published a review of studies investigating Svetol's efficacy, mechanism of action, and bioavailability.[11]

In April and September 2012, The Dr. Oz Show featured green coffee extract, and conducted its own placebo-controlled study as to its efficacy. Dr. Oz specifically recommended either Svetol or GCA as the green coffee extract brands to assist with weight-loss goals.[12][13][14][15] As of 2013, Svetol has increasingly been cited as one of the two brands of green coffee extract that is standardized to contain at least 45% chlorogenic acid,[16][17] and as the brand of choice for green coffee extract supplementation.[18] In 2013 EuroPharma added Svetol to its line, stating that it shows "some of the most impressive clinical data available".[19] As of 2013, Svetol is the number one slimming ingredient in the U.S., and is used in 100 co-branded products in North America.[20]

Clinical studies and mechanism of action

In a study published in 2006 in Phytothérapie, a randomized, placebo-controlled clinical trial used a group of 50 overweight volunteers to test Svetol over the course of 60 days. Subjects receiving Svetol showed significant decrease of weight, body mass index, and fat mass.[21] In a 2007 report published in AgroFOOD Industry Hi-Tech, studies carried out on Svetol's efficacy and mechanism of action were reviewed, including two clinical trials and an in vitro study. The report concluded that "Svetol has demonstrated its validity and could be used to aid the recommended [bland low caloric] diet in a useful and positive manner."[22] The report also concluded that Svetol works as a fat burner to reduce body mass index and increase the lean mass to fat mass ratio via two mechanisms of action: by decreasing intestinal absorption of glucose and also by inhibiting glucose-6-phosphatase in the liver.[22][23] A study published in 2007 in the Journal of International Medical Research detailed two randomized clinical studies which measured the effects on glucose absorption and body mass of a coffee product whose active component was Svetol. The study concluded that Svetol has a significant effect on the absorption and utilization of dietary glucose, and if used for an extended time can result in reduced body mass and body fat.[3]

A 2010 in vitro study detailed in the Journal of Agricultural and Food Chemistry showed that Svetol significantly inhibited glucose 6-phosphate hydrolysis in intact human liver microsomes in a competitive manner, and that this inhibition by Svetol contributes to its antidiabetic, glucose-lowering effects by reducing hepatic glucose production.[24] An overview of randomized clinical trials published in 2011 in Gastroenterology Research and Practice reiterated that intake of Svetol can promote weight loss.[25] In a 2012 study using mice, published in Nutritional Neuroscience, Svetol's effect on insulin resistance and brain energy metabolism was investigated. Svetol significantly attenuated the development of high-fat diet-induced deficits in glucose-tolerance response; it also improved brain mitochondrial energy metabolism, and modulated a number of genes in the brain that are implicated in cellular energy metabolism.[26] And a 2013 study published in Phytotherapy Research determined that longterm Svetol use has a lipolytic activity unrelated to possible trace amounts of caffeine; the study concluded that the release of free fatty acids from adipose tissue from longterm Svetol use is due to Svetol's chlorogenic acid action.[27]

References

  1. ^ a b c d Halliday, Jess. "Berkem Talks Science to Take Svetol into Foods". Nutra Ingredients. December 6, 2006.
  2. ^ Farah, A. (2008). "Chlorogenic Acids from Green Coffee Extract are Highly Bioavailable in Humans" (PDF). Journal of Nutrition. (138): 2309–2315. doi:10.3945/jn.108.095554. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  3. ^ a b Thom, Erling (November–December 2007). "The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people" (PDF). Journal of International Medical Research. 35 (6): 900–908. PMID 18035001.
  4. ^ Svetol – Fact sheet
  5. ^ Halliday, Jess and Chris Mercer. "Slimming Coffee to Launch in UK". BeverageDaily.com. December 6, 2006.
  6. ^ "Berkem’s Svetol Receives Bronze Award". Natural Products Insider. January 15, 2007.
  7. ^ "Naturex Acquires Berkem’s 'Actifs Innovants' Division". ActusNewsWire. January 8, 2008.
  8. ^ a b Halliday, Jess. "Naturex Buys Berkem's Actifs Innovants". Nutra Ingredients. January 8, 2008.
  9. ^ Voinchet, Alexandra. "Naturex : Des acquisitions porteuses". France Bourse. January 17, 2008.
  10. ^ Heller, Lorraine. "Naturex Brings Weight Loss Ingredient to US Foods". Nutra Ingredients. January 14, 2008.
  11. ^ "Naturex reviews fat burning data on Svetol". Nutraceuticals International. February 1, 2008.
  12. ^ "Green Coffee Bean Extract: Fat-Burner or Fraud? Pt 5". The Dr. Oz Show. September 2012.
  13. ^ "The Green Coffee Bean Project". The Dr. Oz Show. September 6, 2012.
  14. ^ "Fact Sheet: Green Coffee Bean". The Dr. Oz Show. April 26, 2012.
  15. ^ Carson, Ralph E. "Dr. Oz Promotes the Green Coffee Bean". FitRx. July 24, 2013.
  16. ^ Pepper, Leslie. The Green Coffee Bean Quick Weight Loss Diet. Macmillan, 2013. p. 24.
  17. ^ Ripenburg, Patricia. Food Can Improve Your Health. Trafford Publishing, 2013. p. 107.
  18. ^ Bagchi, Debasis and Harry G. Preus. Obesity: Epidemiology, Pathophysiology, and Prevention. CRC Press, 2012. p. 489.
  19. ^ Barbanel, Shari. "Weighing Options". Vitamin Retailer. March 2013.
  20. ^ Engredea News & Analysis. "Svetol Comes to Europe". New Hope 360. May 13, 2013.
  21. ^ Dellalibera, O. (November 2006). "Svetol®, green coffee extract, induces weight loss and increases the lean to fat mass ratio in volunteers with overweight problem" (PDF). Phytothérapie. 4 (4): 194–197. doi:10.1007/s10298-006-0181-7. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  22. ^ a b Nardon, K. (September–October 2007). "Green coffee extract Svetol® can manage weight: a review". AgroFOOD Industry Hi-Tech. 18 (5): 37–39. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  23. ^ "Svetol: Review". Functional Foods and Nutraceuticals. May 1, 2008.
  24. ^ Henry-Vitrac, C. (2010). "Contribution of chlorogenic acids to the inhibition of human hepatic glucose-6-phosphatase activity in vitro by Svetol, a standardized decaffeinated green coffee extract". Journal of Agricultural and Food Chemistry. 58 (7): 4141–4144. doi:10.1021/jf9044827. PMID 20302380. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  25. ^ Onakpoya, I. (2011). "The Use of Green Coffee Extract as a Weight Loss Supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials". Gastroenterology Research and Practice. 2011. doi:10.1155/2011/382852. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)CS1 maint: unflagged free DOI (link)
  26. ^ Ho, L. (January 2012). "Dietary supplementation with decaffeinated green coffee improves diet-induced insulin resistance and brain energy metabolism in mice". Nutritional Neuroscience. 15 (1): 37–45. doi:10.1179/1476830511Y.0000000027. PMID 22305652. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  27. ^ Flanagan, J. (December 12, 2013). "Lipolytic activity of Svetol®, a decaffeinated green coffee bean extract". Phytotherapy Research. doi:10.1002/ptr.5085. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
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