Vosaroxin: Difference between revisions

Vosaroxin
Names
	IUPAC name 7-[(3S,4S)-3-Methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(1,3-thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
	Other names Voreloxin
Identifiers
CAS Number	175414-77-4;
3D model (JSmol)	Interactive image;
ChemSpider	8128494;
PubChem CID	9952884;
CompTox Dashboard (EPA)	DTXSID50938662 ;
	InChI InChI=1S/C18H19N5O4S/c1-19-12-8-22(9-13(12)27-2)14-4-3-10-15(24)11(17(25)26)7-23(16(10)21-14)18-20-5-6-28-18/h3-7,12-13,19H,8-9H2,1-2H3,(H,25,26)/t12-,13-/m0/s1 Key: XZAFZXJXZHRNAQ-STQMWFEESA-N; InChI=1/C18H19N5O4S/c1-19-12-8-22(9-13(12)27-2)14-4-3-10-15(24)11(17(25)26)7-23(16(10)21-14)18-20-5-6-28-18/h3-7,12-13,19H,8-9H2,1-2H3,(H,25,26)/t12-,13-/m0/s1 Key: XZAFZXJXZHRNAQ-STQMWFEEBT;
	SMILES CN[C@H]1CN(C[C@@H]1OC)C2=NC3=C(C=C2)C(=O)C(=CN3C4=NC=CS4)C(=O)O;
Properties
Chemical formula	C18H19N5O4S
Molar mass	401.44 g·mol−1
Density	1.5±0.1 g/cm3
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

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Revision as of 09:59, 28 May 2015

Vosaroxin (AG-7352, SPC-595, SNS 595, voreloxin) is a topoisomerase II inhibitor causing site-selective DNA damage.It is under phase III clinical trial investigation for acute myelogenous leukemia (AML) and ovarian cancer sponsored by Sunesis.^[2]

Mechanism of action

Vosaroxin is a naphthyridine analog of the anticancer quinolone derivatives (AQDs), a class of compounds that has not been used previously for the treatment of cancer. Topoisomerase II enzymes are essential for the survival of eukaryotic cells. Vosaroxin hinders the reunion of topoisomerase II-induced double-strand breaks at selective sites in DNA, resulting in G2 arrest and cell death by apoptosis.^[3]

References

^ "Voreloxin information in ChemSpider".
^ "Vosaroxin". Selleck Chemicals.
^ "Vosaroxin (Formerly Voreloxin)". Sunesis.

This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it.

http://www.medchemexpress.com/voreloxin.html

[1] "Voreloxin information in ChemSpider".

[2] "Vosaroxin". Selleck Chemicals.

[3] "Vosaroxin (Formerly Voreloxin)". Sunesis.

[2]

[3]

Revision as of 17:08, 4 March 2015 edit DePiep (talk \| contribs) Extended confirmed users 294,285 edits mNo edit summary ← Previous edit		Revision as of 09:59, 28 May 2015 edit undo Liuyishan (talk \| contribs) 20 edits →References: Voreloxin(SNS-595; AG 7352) is a small molecule and a naphthyridine analogue with antineoplastic activity; inhibitor of Topo II. Next edit →
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			http://www.medchemexpress.com/voreloxin.html