TNFAIP8L2: Difference between revisions

TNFAIP8L2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3F4M
Identifiers
Aliases	TNFAIP8L2, TIPE2, TNF alpha induced protein 8 like 2
External IDs	OMIM: 612112; MGI: 1917019; HomoloGene: 56998; GeneCards: TNFAIP8L2; OMA:TNFAIP8L2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	151,159,749 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	95,049,671 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; blood; ; mucosa of ileum; ; spleen; ; appendix; ; lymph node; ; gonad; ; testicle; ; trabecular bone;
	Top expressed in
	granulocyte; ; mesenteric lymph nodes; ; blood; ; stroma of bone marrow; ; blastocyst; ; spleen; ; subcutaneous adipose tissue; ; thymus; ; jejunum; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm;
Biological process	innate immune response; negative regulation of T cell activation; negative regulation of inflammatory response; immune system process; regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	79626
	69769
	ENSG00000163154
	ENSMUSG00000013707
	Q6P589
	Q9D8Y7
	NM_024575
	NM_027206
	NP_078851
	NP_081482
	Wikidata
View/Edit Human	View/Edit Mouse

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Revision as of 14:17, 19 May 2018

TNF alpha induced protein 8 like 2 (TNFAIP8L2), also known as TIPE2, is a protein that in humans is encoded by the TNFAIP8L2 gene. It is preferentially expressed in human myeloid cell types and serves as an immune checkpoint regulator of inflammation and metabolism.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163154 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000013707 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Li T, Wang W, et al. (July 2018). "Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism". Molecular Immunology. 99: 154–162. doi:10.1016/j.molimm.2018.05.007.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163154 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000013707 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Li_et_al_2018-5] Li T, Wang W, et al. (July 2018). "Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism". Molecular Immunology. 99: 154–162. doi:10.1016/j.molimm.2018.05.007.

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@@ Line 1: / Line 1: @@
 {{Infobox_gene}}
+'''TNF alpha induced protein 8 like 2''' (TNFAIP8L2), also known as '''TIPE2''', is a [[protein]] that in humans is encoded by the TNFAIP8L2 [[gene]].  It is preferentially expressed in human myeloid cell types and serves as an immune checkpoint regulator of inflammation and metabolism.<ref name="Li et al 2018">{{cite journal  |vauthors=Li T, Wang W, etal |title=Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism |journal=Molecular Immunology |doi=10.1016/j.molimm.2018.05.007 |date=July 2018| volume = 99 |pages = 154-162 }}</ref>
-'''TNF alpha induced protein 8 like 2''' is a [[protein]] that in humans is encoded by the TNFAIP8L2 [[gene]].
-<ref name="entrez">
-{{cite web
-| title = Entrez Gene: TNF alpha induced protein 8 like 2
-| url = http://www.ncbi.nlm.nih.gov/gene/79626
-| accessdate = 2018-05-19
-}}</ref>
@@ Line 14: / Line 9: @@
 {{reflist}}
-== Further reading ==
-{{refbegin | 2}}
-*{{cite journal |vauthors=Zhang G, Hao C, Lou Y, Xi W, Wang X, Wang Y, Qu Z, Guo C, Chen Y, Zhang Y, Liu S |title=Tissue-specific expression of TIPE2 provides insights into its function |journal=Mol. Immunol. |volume=47 |issue=15 |pages=2435–42 |date=September 2010 |pmid=20663561 |doi=10.1016/j.molimm.2010.06.016 |url=}}
-*{{cite journal |vauthors=Zhang L, Shi Y, Wang Y, Zhu F, Wang Q, Ma C, Chen YH, Zhang L |title=The unique expression profile of human TIPE2 suggests new functions beyond its role in immune regulation |journal=Mol. Immunol. |volume=48 |issue=9-10 |pages=1209–15 |date=May 2011 |pmid=21459448 |doi=10.1016/j.molimm.2011.03.001 |url=}}
-*{{cite journal |vauthors=Xi W, Hu Y, Liu Y, Zhang J, Wang L, Lou Y, Qu Z, Cui J, Zhang G, Liang X, Ma C, Gao C, Chen Y, Liu S |title=Roles of TIPE2 in hepatitis B virus-induced hepatic inflammation in humans and mice |journal=Mol. Immunol. |volume=48 |issue=9-10 |pages=1203–8 |date=May 2011 |pmid=21466895 |doi=10.1016/j.molimm.2011.03.002 |url=}}
-*{{cite journal |vauthors=Gus-Brautbar Y, Johnson D, Zhang L, Sun H, Wang P, Zhang S, Zhang L, Chen YH |title=The anti-inflammatory TIPE2 is an inhibitor of the oncogenic Ras |journal=Mol. Cell |volume=45 |issue=5 |pages=610–8 |date=March 2012 |pmid=22326055 |pmc=3299909 |doi=10.1016/j.molcel.2012.01.006 |url=}}
-*{{cite journal |vauthors=Jia L, Gui B, Tian P, Yao G, Fu R, Wang L, Ge H, Ou Y |title=TIPE2, a novel biomarker for clinical chronic kidney allograft rejection |journal=Artif Organs |volume=37 |issue=2 |pages=221–5 |date=February 2013 |pmid=23009108 |doi=10.1111/j.1525-1594.2012.01527.x |url=}}
-*{{cite journal |vauthors=Ma Y, Liu X, Wei Z, Wang X, Wang Z, Zhong W, Li Y, Zhu F, Guo C, Zhang L, Wang X |title=The expression and significance of TIPE2 in peripheral blood mononuclear cells from asthmatic children |journal=Scand. J. Immunol. |volume=78 |issue=6 |pages=523–8 |date=December 2013 |pmid=24107080 |doi=10.1111/sji.12110 |url=}}
-*{{cite journal |vauthors=Cao X, Zhang L, Shi Y, Sun Y, Dai S, Guo C, Zhu F, Wang Q, Wang J, Wang X, Chen YH, Zhang L |title=Human tumor necrosis factor (TNF)-alpha-induced protein 8-like 2 suppresses hepatocellular carcinoma metastasis through inhibiting Rac1 |journal=Mol. Cancer |volume=12 |issue=1 |pages=149 |date=November 2013 |pmid=24274578 |pmc=4176125 |doi=10.1186/1476-4598-12-149 |url=}}
-*{{cite journal |vauthors=Lou Y, Zhang G, Geng M, Zhang W, Cui J, Liu S |title=TIPE2 negatively regulates inflammation by switching arginine metabolism from nitric oxide synthase to arginase |journal=PLoS ONE |volume=9 |issue=5 |pages=e96508 |date=2014 |pmid=24806446 |pmc=4013027 |doi=10.1371/journal.pone.0096508 |url=}}
-*{{cite journal |vauthors=Li XM, Su JR, Yan SP, Cheng ZL, Yang TT, Zhu Q |title=A novel inflammatory regulator TIPE2 inhibits TLR4-mediated development of colon cancer via caspase-8 |journal=Cancer Biomark |volume=14 |issue=4 |pages=233–40 |date=2014 |pmid=24934366 |doi=10.3233/CBM-140402 |url=}}
-{{refend}}