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Iwona Stroynowski (born August 8, 1950) is a Professor in the Department of Immunology and Microbiology at University of Texas Southwestern Medical Center in Dallas,TX. She discovered the process of gene expression control called attenuation early in her career, the first example of a riboswitch mechanism. Later, she made discoveries about Major Histocompatibility Antigens, especially the non--canonical ones.
Early Life and Education
Iwona Fleszar[1] was born on August 8, 1950[2] in Poland. She became an American citizen in 1982.[3] She received the PhD from Stanford University in 1979 in the field of Genetics.[4] At Stanford, working with Charles Yanofsky, Iwona Stroynowski discovered the attenuation system regulating bacterial amino acid synthesis pathways.[5]
Academic and Research Career
Iwona Stroynowski undertook an extended postdoctoral research period with Leroy Hood at California Institute of Technology, during which she changed fields from bacterial genetics to cellular immunology. Then she became an Associate Professor at University of Texas Southwestern Medical Center in the Department of Immunology and Microbiology.[4] Her current rank there is Professor of Immunology and Microbiology.[4]
Stroynowski's research has delved into the functions of the non-canonical proteins of the Major Histocompatibility Complex, particularly Qa, a protein which is produced in both membrane bound and soluble forms from the same gene, due to alternative splicing.[6] Interferon induction of H-2 antigens was another of her findings.[7] Her laboratory has shown that the Qa antigen has a role in protection from tumor formation.[8]
Personal Life
Iwona Stroynowski is married to physicist Ryszard Stroynowski of Southern Methodist University and they have two daughters.[1]
Honors and Awards
Senior Scholar, Ellison Foundation, 2001[4]
References
- ^ a b "Ryszard Stroynowski". Poles.org. Retrieved August 31, 2018.
{{cite web}}: Cite has empty unknown parameter:|dead-url=(help) - ^ "Iwona Stroynowski". Instant Checkmate. Retrieved August 31, 2018.
{{cite web}}: Cite has empty unknown parameter:|dead-url=(help) - ^ "Letter from Iwona Stroynowski to Joshua Lederberg". US National Library of Medicine. May 18, 1984. Retrieved August 31, 2018.
{{cite web}}: Cite has empty unknown parameter:|dead-url=(help) - ^ a b c d "Iwona Stroynowski". University of Texas Southwestern. Retrieved August 31, 2018.
{{cite web}}: Cite has empty unknown parameter:|dead-url=(help) - ^ Iwona Stroynowski, Magda van Cleemput, and Charles Yanofsky. (1982) "Superattenuation in the tryptophan operon of Serratia marcescens" Nature 298:38-41.
- ^ I Stroynowski, M Soloski, MG Low, and L Hood (1987) "A single gene encodes soluble and membrane-bound forms of the major histocompatibility Qa-2 antigen: anchoring of the product by a phospholipid tail." Science 239:1302-1306.
- ^ B Korber, N Mermod, L Hood, and I Stroynowski,(1988) "Regulation of gene expression by interferons: control of the H-2 promoter responses."Science 239: 1302-1306.
- ^ EY Chiang and I Stroynowski (2005) "Protective immunity to disparate tumors is mediated by a nonpolymorphic class I MHC molecule." J. Immunol. 174: 5367-5374.