SHC014-CoV: Difference between revisions
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'''SHC014-CoV''' is a [[Severe acute respiratory syndrome coronavirus|SARS]]-like [[coronavirus]] (SL-COV) which infects [[horseshoe bats]] (f. Rhinolophidae), first discovered in China in 2013.<ref>Ge, X., Li, J., Yang, X. et al. Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature 503, 535–538 (2013). https://doi.org/10.1038/nature12711</ref> |
'''SHC014-CoV''' is a [[Severe acute respiratory syndrome coronavirus|SARS]]-like [[coronavirus]] (SL-COV) which infects [[horseshoe bats]] (f. Rhinolophidae), first discovered in China in 2013.<ref>Ge, X., Li, J., Yang, X. et al. Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature 503, 535–538 (2013). https://doi.org/10.1038/nature12711</ref> |
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In 2015, the [[University of North Carolina at Chapel Hill]] and [[Wuhan Institute of Virology]] conducted research showing the virus could be made to infect the human [[HeLa]] cell line, through the use of [[reverse genetics]] to create a [[Chimera (virus)|chimeric]] virus consisting of a surface protein of SHC014 and the backbone of a SARS virus.<ref>Menachery, V., Yount, B., Debbink, K. et al. [https://www.nature.com/articles/nm.3985 A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence.] Nat Med 21, 1508–1513 (2015) https://doi.org/10.1038/nm.3985</ref><ref>{{cite journal|title=Engineered bat virus stirs debate over risky research: Lab-made coronavirus related to SARS can infect human cells|url=https://www.nature.com/news/engineered-bat-virus-stirs-debate-over-risky-research-1.18787?WT.mc_id=TWT_NatureNews|first=Declan|last=Butler|journal=Nature News|publisher=Nature|date=12 November 2015|doi=10.1038/nature.2015.18787|access-date=14 March 2020|archive-url=https://web.archive.org/web/20200314030013/https://www.nature.com/news/engineered-bat-virus-stirs-debate-over-risky-research-1.18787?WT.mc_id=TWT_NatureNews|archive-date=14 March 2020|url-status=live}}</ref> The SL-SHC014-MA15 version of the virus, primarily engineered to infect mice, has been shown to differ 7% (over 5,000 nucleotides) from [[SARS-CoV-2]], the cause of a human [[2019–20 coronavirus pandemic|pandemic in 2019-2020]].<ref>Shan-Lu Liu, Linda J. Saif, Susan R. Weiss & Lishan Su (2020) No credible evidence supporting claims of the laboratory engineering of SARS-CoV-2, Emerging Microbes & Infections, 9:1, 505-507, https://www.tandfonline.com/doi/full/10.1080/22221751.2020.1733440 {{Webarchive|url=https://web.archive.org/web/20200302035224/https://www.tandfonline.com/doi/full/10.1080/22221751.2020.1733440 |date=2020-03-02 }}</ref> In April 2020, US President Donald Trump implied during a Members of the Coronavirus Task Force Press Briefing<ref>{{Cite web|url=https://www.washingtonpost.com/politics/2020/04/15/trump-coronavirus-briefing-takeaways/|title=What you need to know from Wednesday’s White House coronavirus briefing|last=Phillips|first=Amber|date=April 15, 2020|website=The Washington Post|url-status=live|archive-url=https://web.archive.org/web/20200417171539/https://www.washingtonpost.com/politics/2020/04/15/trump-coronavirus-briefing-takeaways/|archive-date=April 17, 2020|access-date=April 18, 2020}}</ref> that it is possible that because of its ability to mutate extremely quickly<ref>{{Cite web|url=https://www.rt.com/news/486425-covid-19-mutations-deadlier-strains/|title=Covid-19 mutations underestimated, Chinese scientists warn, as DEADLIEST strains grip Europe and US|website=RT International|language=en|access-date=2020-04-21}}</ref>, SHC014-CoV{{Original research inline|date=April 2020}} could be the origin of [[SARS-CoV-2]], the cause of a human [[2019–20 coronavirus pandemic|pandemic in 2019-2020]], stating that it's possible an intern at the Wuhan Institute of Virology was infected by accident and spread the virus to her boyfriend and others when she went to a nearby wet market.<ref>{{Cite news|last=Brett|first=Baier|url=https://www.foxnews.com/politics/coronavirus-wuhan-lab-china-compete-us-sources|title=Sources believe coronavirus outbreak originated in Wuhan lab as part of China's efforts to compete with US|date=April 15, 2020|work=FOX NEWS|access-date=April 18, 2020|url-status=live|last2=Re|first2=Gregg}}</ref> This virus was also researched at the Vector laboratory in Novosibirsk, Russia.<ref>{{Cite web|url=https://amp.theguardian.com/world/2019/sep/17/blast-sparks-fire-at-russian-laboratory-housing-smallpox-virus|title=Blast sparks fire at Russian laboratory housing smallpox virus {{!}} Russia {{!}} The Guardian|website=amp.theguardian.com|access-date=2020-04-23}}</ref> |
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==References== |
==References== |
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Revision as of 03:20, 23 April 2020
SHC014-CoV is a SARS-like coronavirus (SL-COV) which infects horseshoe bats (f. Rhinolophidae), first discovered in China in 2013.[1]
References
- ^ Ge, X., Li, J., Yang, X. et al. Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature 503, 535–538 (2013). https://doi.org/10.1038/nature12711
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