Variants of SARS-CoV-2: Difference between revisions
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==VOC-202012/01== |
==VOC-202012/01== |
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[[VOC-202012/01]], found in the United Kingdom<ref name="Chandetal.">{{cite report |
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|first1=Meera |last1=Chand |
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|first2=Susan |last2=Hopkins |
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|first10=Jeff |last10=Barrett |
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|url=https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/947048/Technical_Briefing_VOC_SH_NJL2_SH2.pdf |title=Investigation of novel SARS-COV-2 variant: Variant of Concern 202012/01 |date=21 December 2020 |accessdate=23 December 2020 |ref={{sfnref|Chand et al.|2020}} |publisher=[[Public Health England]]}}</ref> |
|url=https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/947048/Technical_Briefing_VOC_SH_NJL2_SH2.pdf |title=Investigation of novel SARS-COV-2 variant: Variant of Concern 202012/01 |date=21 December 2020 |accessdate=23 December 2020 |ref={{sfnref|Chand et al.|2020}} |publisher=[[Public Health England]]}}</ref> |
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'''Variant of Concern 202012/01''' ('''VOC-202012/01'''),<ref name="Chandetal."/> previously known as the first '''Variant Under Investigation in December 2020''' ('''VUI – 202012/01''')<ref>{{Cite web |title=PHE investigating a novel strain of COVID-19 |author= |publisher=Public Health England |date=14 December 2020 |url= https://www.gov.uk/government/news/phe-investigating-a-novel-strain-of-covid-19}}</ref>{{efn|name="withoutdash"}}{{efn|name=nomenclature}} and also as lineage '''B.1.1.7''',<ref name="Rambaut et al"/><ref name="Science Mag">{{Cite web |ref={{sfnref|Kupferschmidt|2020}} |last=Kupferschmidt|first=Kai |date=20 December 2020 |title=Mutant coronavirus in the United Kingdom sets off alarms but its importance remains unclear|url=https://www.sciencemag.org/news/2020/12/mutant-coronavirus-united-kingdom-sets-alarms-its-importance-remains-unclear|url-status=live|archive-url=|archive-date=|access-date=21 December 2020 |website=[[Science (journal)|Science Mag]] |language=en}}</ref> is a [[Variant (biology)|variant]] of [[severe acute respiratory syndrome coronavirus 2|SARS-CoV-2]], the virus that causes [[coronavirus disease 2019]] (COVID-19).<ref name="NYT-20201221">{{cite news |last1=Zimmer |first1=Carel |last2=Carey |first2=Benedict |title=The U.K. Coronavirus Variant: What We Know = A newly identified variant of the SARS-CoV-2 virus appears to be more contagious than established ones. Here’s what scientists know. |url=https://www.nytimes.com/2020/12/21/health/new-covid-strain-uk.html |date=21 December 2020 |work=[[The New York Times]] |accessdate=23 December 2020 }}</ref> The variant was first detected in October 2020 during the [[COVID-19 pandemic in the United Kingdom]] from a sample taken the previous month,<ref name="BBC">{{Cite news |title=Covid: Ireland, Italy, Belgium and Netherlands ban flights from UK |author= |website=BBC News |date=20 December 2020 |url= https://www.bbc.co.uk/news/world-europe-55385768}}</ref> and it quickly began to spread by mid-December. It is correlated with a significant increase in the rate of [[COVID-19 pandemic in the United Kingdom#New cases by day reported|COVID-19 infection in United Kingdom]]; this increase is thought to be at least partly because of change N501Y inside the [[Peplomer|spike glycoprotein]]'s [[Severe acute respiratory syndrome coronavirus 2#Structural biology|receptor-binding domain]], which is needed for binding to [[Angiotensin-converting enzyme 2|ACE2]] in human cells. |
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==References== |
==References== |
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Revision as of 22:04, 23 December 2020
Thousands of SARS-CoV-2 genomes sampled worldwide are publicly available.[1]
SARS-CoV-2 had at least six main strains, named L, S, V, G, GR, and GH, as of August 2020.[2][3] Strain L was the first strain, discovered in Wuhan in December 2019. As of August 2020, strain G (and related strains GR and GH) were the most widespread; L and V were gradually disappearing.
There are several mutated variants of the SARS-CoV-2 virus:
501.V2
- 501.V2 Variant, found in South Africa[4]
Cluster 5
Cluster 5, also referred to as ΔFVI-spike by the Danish State Serum Institute (SSI), is a mutated variant of the SARS-CoV-2 virus. It was discovered in Northern Jutland, Denmark, and is believed to have been spread from minks to humans via mink farms. On 4 November 2020, it was announced that the mink population in Denmark would be culled to prevent the possible spread of this mutation and reduce the risk of new mutations happening. A lockdown and travel restrictions were introduced in seven municipalities of Northern Jutland to prevent the mutation from spreading, which could compromise national or international responses to the COVID-19 pandemic.
The World Health Organization (WHO) has stated that cluster 5 has a "moderately decreased sensitivity to neutralizing antibodies".[5] SSI warned that the mutation could reduce the effect of COVID-19 vaccines under development, although it was unlikely to render them useless. Following the lockdown and mass-testing, SSI announced on 19 November 2020 that cluster 5 in all probability had become extinct.[6]
VOC-202012/01
VOC-202012/01, found in the United Kingdom[7]
Variant of Concern 202012/01 (VOC-202012/01),[7] previously known as the first Variant Under Investigation in December 2020 (VUI – 202012/01)[8][a][b] and also as lineage B.1.1.7,[9][10] is a variant of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19).[11] The variant was first detected in October 2020 during the COVID-19 pandemic in the United Kingdom from a sample taken the previous month,[12] and it quickly began to spread by mid-December. It is correlated with a significant increase in the rate of COVID-19 infection in United Kingdom; this increase is thought to be at least partly because of change N501Y inside the spike glycoprotein's receptor-binding domain, which is needed for binding to ACE2 in human cells.
References
- ^ "Genomic epidemiology of novel coronavirus - Global subsampling". Nextstrain. Archived from the original on 20 April 2020. Retrieved 7 May 2020.
- ^ "The six strains of SARS-CoV-2". ScienceDaily. 2020-08-03. Retrieved 2020-12-23.
{{cite web}}: CS1 maint: url-status (link) - ^ https://www.sciencedaily.com/releases/2020/08/200803105246.htm ScienceDaily.com
- ^ "South Africa announces a new coronavirus variant". The New York Times. 18 December 2020. Retrieved 23 December 2020.
- ^ "6 countries find coronavirus at mink farms; fears mutation could hinder vaccine". The Times of Israel. 2020-11-08. Retrieved 2020-11-09.
Italy, the Netherlands, Spain and Sweden are the other nations to have discovered SARS-CoV-2 in minks, WHO said in a statement.
- ^ "De fleste restriktioner læmpes i Nordjylland". Sundheds- og Ældreministeriet. 19 November 2020.
- ^ a b Chand, Meera; Hopkins, Susan; Dabrera, Gavin; Achison, Christina; Barclay, Wendy; Ferguson, Neil; Volz, Erik; Loman, Nick; Rambaut, Andrew; Barrett, Jeff (21 December 2020). Investigation of novel SARS-COV-2 variant: Variant of Concern 202012/01 (PDF) (Report). Public Health England. Retrieved 23 December 2020.
- ^ "PHE investigating a novel strain of COVID-19". Public Health England. 14 December 2020.
- ^ Cite error: The named reference
Rambaut et alwas invoked but never defined (see the help page). - ^ Kupferschmidt, Kai (20 December 2020). "Mutant coronavirus in the United Kingdom sets off alarms but its importance remains unclear". Science Mag. Retrieved 21 December 2020.
{{cite web}}: CS1 maint: ref duplicates default (link) CS1 maint: url-status (link) - ^ Zimmer, Carel; Carey, Benedict (21 December 2020). "The U.K. Coronavirus Variant: What We Know = A newly identified variant of the SARS-CoV-2 virus appears to be more contagious than established ones. Here's what scientists know". The New York Times. Retrieved 23 December 2020.
- ^ "Covid: Ireland, Italy, Belgium and Netherlands ban flights from UK". BBC News. 20 December 2020.
Cite error: There are <ref group=lower-alpha> tags or {{efn}} templates on this page, but the references will not show without a {{reflist|group=lower-alpha}} template or {{notelist}} template (see the help page).