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Revision as of 19:40, 30 April 2021
W. Wallace Cleland | |
|---|---|
| Born | January 6, 1930 |
| Died | March 6, 2013 (aged 83) |
| Nationality | United States |
| Alma mater | Oberlin College (A.B., 1950) University of Wisconsin (M.S., 1953) (Ph.D., 1955) |
| Known for | Enzyme kinetics and mechanism |
| Awards | Repligen Award |
| Scientific career | |
| Fields | Biochemistry |
| Institutions | University of Wisconsin |
William Wallace Cleland (January 6, 1930 – March 6, 2013[1], often cited as W. W. Cleland, and known almost universally as "Mo Cleland", was a University of Wisconsin-Madison biochemistry professor. His research was concerned with enzyme reaction mechanism and enzyme kinetics,[2] especially multiple-substrate enzymes. He was elected to the National Academy of Sciences in 1985.
Life and education
Cleland was born in 1930 in Baltimore, Maryland. He received his A.B. from Oberlin College in 1950 and his M.S. and Ph.D. from the University of Wisconsin–Madison in 1953 and 1955, respectively.[3] He was an avid stamp collector and was awarded the Lifetime Achievement Award in Philately by the Smithsonian Institution in 2008. Cleland died on March 6, 2013 after falling on ice.[4]
Career
After carrying out postdoctoral research at the University of Chicago he returned to University of Wisconsin–Madison, where he became Assistant Professor in 1959. In 1962 he was promoted to Associate Professor and then Professor in 1966. He became J. Johnson Professor of Biochemistry in 1978, and Steenbock Professor of Chemical Science in 1982.[2]
Kresge, Simoni and Hill[5] have presented a general appreciation of Cleland's life and career.
Scientific contributions
Papers
Cleland's research focused on the use of enzyme kinetics to deduce enzyme mechanisms, especially those involved in phospho and acyl transfers.[3] He pioneered the kinetic and mechanistic study of enzymes with more than one substrate, and he was probably the first to make a systematic classification of mechanisms and the corresponding kinetic equations.[6][7][8]
He was the first to use dithiothreitol for the reduction of disulfide bonds in proteins, and the compound is accordingly often called Cleland's reagent.[9] [10]
Notable publications
Books
- Enzyme Kinetics and Mechanism (2007) Paul F. Cook and W.W. Cleland. Garland Science (ISBN 978-0815341406)
Awards and recognition
- 1985 - Elected to the National Academy of Sciences
- 1986 - Fulbright Senior Scholar Award[3]
- 1990 - Merck Award (American Society for Biochemistry and Molecular Biology)[3]
- 1993 - Alfred Bader Award in Bioinorganic or Bioorganic Chemistry (American Chemical Society)[3]
- 1995 - Repligen Corporation Award in Chemistry of Biological Processes(Biological Chemistry Division of the American Chemical Society)[3]
- 1999 - Stein and Moore Award (Protein Society)[3]
- 2008 - Lifetime Achievement Award in Philately, Smithsonian Institution[11]
References
- ^ "In Memoriam". National Academy of Sciences. Retrieved 8 March 2013.
- ^ a b Academic home page
- ^ a b c d e f g J. Biol. Chem. biographical article
- ^ "Biochemistry Mourns the Loss of "Mo" Cleland". News 2013. Department of Biochemistry, UW-Madison. Retrieved 9 March 2013.
- ^ Kresge; Simoni, Robert D.; Hill, Robert L. (2006). "Determining enzyme mechanisms by kinetic analysis: The work of W. Wallace Cleland". J. Biol. Chem. 281 (46): e37.
- ^ Cleland, W.W (1963). "The kinetics of enzyme-catalyzed reactions with two or more substrates or products". Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects. 67: 188–196. doi:10.1016/0926-6569(63)90227-X.
- ^ Cleland, W.W (1963). "The kinetics of enzyme-catalyzed reactions with two or more substrates or products". Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects. 67: 104–137. doi:10.1016/0926-6569(63)90211-6.
- ^ Cleland, W.W (1963). "The kinetics of enzyme-catalyzed reactions with two or more substrates or products". Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects. 67: 173–187. doi:10.1016/0926-6569(63)90226-8.
- ^ Cleland, W.W. (April 1964). "Dithiothreitol, A New Protective Reagent for SH Groups". Biochemistry. 3 (4): 480–2. doi:10.1021/bi00892a002. PMID 14192894.
- ^ Cook, Paul; Cleland, William Wallace (2007). Enzyme kinetics and mechanism. London: Garland Science. ISBN 978-0-8153-4140-6.
- ^ "Cleland, W. Wallace "Mo"". Madison.com. March 10, 2013. Retrieved 12 March 2013.
Category:1930 births Category:2013 deaths Category:Members of the United States National Academy of Sciences Category:American biochemists Category:Oberlin College alumni Category:University of Wisconsin–Madison alumni Category:University of Wisconsin–Madison faculty