Talk:List of autoimmune diseases

Autism

In the wikipedia autism article, I read that

• Maternal nutrition and inflammation during preconception and pregnancy influences fetal neurodevelopment. Intrauterine growth restriction is associated with ASD, in both term and preterm infants. Maternal inflammatory and autoimmune diseases may damage fetal tissues, aggravating a genetic problem or damaging the nervous system.

and

• There is evidence that gut–brain axis abnormalities may be involved. A 2015 review proposed that immune dysregulation, gastrointestinal inflammation, malfunction of the autonomic nervous system, gut flora alterations, and food metabolites may cause brain neuroinflammation and dysfunction. A 2016 review concludes that enteric nervous system abnormalities might play a role in neurological disorders such as autism. Neural connections and the immune system are a pathway that may allow diseases originated in the intestine to spread to the brain.

I propose, therefore, that autism be added to the list under the "non-autoimmune" heading, to demonstrate that it at least being considered as a possible autoimmune disease. Objections? Piedmont (talk) 11:19, 2 May 2021 (UTC)

I have added this change, as proposed. Piedmont (talk) 11:14, 14 May 2021 (UTC)

List of qualifiers - updated

My apologies for not focusing on this but I am about to spend some time, so if you are interested in this page, please post here and I will try to accommodate any comments and suggestions.

First, I would like to come up with a way to characterize these diseases better. Here are the issues:

1. We need a way to decide whether a disease is "officially" autoimmune. The Rose Bona criteria are published and the original list was part of the article on Autoimmune Disease - when the list was moved, the reference to Rose Bona was not. I will add it back as appropriate. However, the Rose Bona criteria, a modification of the Witebsky postulates (which I will also notate) are so stringent that only a handful of diseases qualify (autoimmune thyroiditis and myasthenia gravis are 2 I know of). The rest are implicated by the presence of antibodies (strong evidence of autoimmune etiology) or simply circumstantial evidence (no other etiology, predominantly affect women, follow a pattern of flare-ups and remissions). In many cases, it is a judgment call where a disease fits.

2. We need a way to characterize diseases that are caused by autoimmune processes only some of the time. A patient who has their pancreas removed due to cancer will suffer from type 1 diabetes, but not from an autoimmune process. In other cases, infections or genetics can cause disease in one individual that is caused by autoimmune processes in another. In genetics, we use the term "penetrance" to describe the rate at which people with the gene exhibit the phenotype we expect. In autoimmunity, we need a term to describe the percentage of persons suffering from a disease that have the disease due to an autoimmune process.

I would love feedback on both of these issues.

Also please advise on my Wikipedia etiquette, as I am still not well versed in it.

Second, as I had posted here earlier, I will be changing the table at least to remove the flags referring to the prior version of the table:

A "Accepted" in prior version of this table S "Suspected" in the prior version of this table N Not listed in prior version of this table Y Listed in the prior version of this table with "Accepted/Suspected" left blank

The prior version of the table is over 3 years old and if someone wants to see it they can go to the history.

I also propose to reuse "N" to indicate "New research" that changes the status of a condition. For example, Chronic Fatigue Syndrome has received some new credibility from the NIH. I propose that any disease that has a footnote pointing to research published in the past year that changes the "Level of Acceptance" should be flagged with an N and a footnote. I propose to adhere to a "no footnote, no N" rule. This will help ensure all changes are supported with references. I will review on a regular basis and remove "N" values that are a year or so old to keep the meaning accurate.

Aaron Abend (talk) 12:37, 26 December 2019 (UTC)

2602:306:35FA:B090:F9B8:34:BF0A:72E2 (talk) 03:57, 10 July 2017 (UTC) Interstitial Cystitis is listed as Kidney Disease. It is a Urinary Bladder Disease (as you'll see when you click its related link(s)). July 9, 2017 2602:306:35FA:B090:F9B8:34:BF0A:72E2 (talk) 03:57, 10 July 2017 (UTC)

Thanks for the info - I will change that! Aaron Abend (talk) 12:37, 26 December 2019 (UTC)

A further issue is the qualifiers list's "C" designation, "given to diseases that are classified by Rose and Bona as having 'circumstantial' evidence of autoimmune etiology. [These] are, therefore, actual autoimmune diseases."

Actual diseases, yes. Actually autoimmune, not necessarily, for the evidence of that is, per Messrs. Rose and Bona, merely circumstantial. Mucketymuck (talk) 04:11, 3 October 2020 (UTC) 04:09, 3 October 2020 (UTC)

External links modified

Hello fellow Wikipedians,

I have just modified 3 external links on List of autoimmune diseases. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:

• Added archive https://web.archive.org/web/20110929090419/http://www.wjgnet.com/1007-9327/14/3374.asp to http://www.wjgnet.com/1007-9327/14/3374.asp
• Added archive https://web.archive.org/web/20100706154955/http://www.aad.org/public/publications/pamphlets/common_alopecia.html to http://www.aad.org/public/publications/pamphlets/common_alopecia.html
• Added archive https://web.archive.org/web/20080517030514/http://www.bcm.edu/oto/grand/4893.html to http://www.bcm.edu/oto/grand/4893.html

When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.

Y An editor has reviewed this edit and fixed any errors that were found.

• If you have discovered URLs which were erroneously considered dead by the bot, you can report them with this tool.
• If you found an error with any archives or the URLs themselves, you can fix them with this tool.

Cheers.—InternetArchiveBot (Report bug) 09:45, 20 May 2017 (UTC)

Good Bot. GangofOne (talk) 19:17, 23 June 2017 (UTC)

Stanford says "Narcolepsy is an autoimmune disease."

(at least since the H1N1 flu vaccine triggered Narcolepsy phenomenon) Source: http://med.stanford.edu/narcolepsy.html May I change it? — Preceding unsigned comment added by 2605:A000:D020:C900:4990:F141:538A:DE59 (talk) 14:16, 6 September 2017 (UTC)

Who is Rose Bona and what are her qualifications?

"C A disease, regarded as autoimmune, that is often found in individuals with another autoimmune condition. This designation is given to diseases that are classified by Rose Bona as having "circumstantial" evidence of autoimmune etiology. Diseases in this list with a "C" are, therefore, actual autoimmune diseases, rather than comorbid symptoms, which appear after this list."

So who is Rose Bona? Her name isn't a link to the article on her. A google search on her turned up nothing.

And isn't the Wikipedia rule that evidence must have been prior published in an authoritative journal, archive, book, or periodical. That is, Wikipedia isn't supposed to publish original research.

Anyways, so who is Rose Bona? Thanks.

50.71.169.56 (talk) 09:48, 27 September 2017 (UTC)

I did some searching and found a 1993 paper by Noel R. Rose and Constantin Bona. (Link) I'm pretty confused by the table and the descriptors listed. How was this table originally compiled? Natureium (talk) 22:49, 25 December 2017 (UTC)

External links modified

Hello fellow Wikipedians,

I have just modified one external link on List of autoimmune diseases. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:

• Added archive https://web.archive.org/web/20111001214949/http://www.jrheum.com/subscribers/08/06/992.html to http://www.jrheum.com/subscribers/08/06/992.html

When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.

This message was posted before February 2018. After February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than regular verification using the archive tool instructions below. Editors have permission to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the RfC before doing mass systematic removals. This message is updated dynamically through the template {{source check}} (last update: 5 June 2024).

• If you have discovered URLs which were erroneously considered dead by the bot, you can report them with this tool.
• If you found an error with any archives or the URLs themselves, you can fix them with this tool.

Cheers.—InternetArchiveBot (Report bug) 16:33, 28 December 2017 (UTC)

Autoimmune autonomic ganglionopathy needs to be added to this list, and written by a medical professional.

Hello everybody - Would a medical professional please add to this list and describe Autoimmune autonomic ganglionopathy (AAG)? I have added a link to its Wikipedia article under the "See also" section because I am not a medical professional and I am not qualified to write about this. You may help someone who has this rare disease. Thank you. Entertainment Buff 16:23, 10 January 2019 (UTC)