D-DOPA: Difference between revisions
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'''{{sm|d}}-DOPA''' ('''{{sm|d}}'''-3,4-'''d'''ihydr'''o'''xy'''p'''henyl'''a'''lanine; '''dextrodopa''') is similar to [[L-DOPA|{{sm|l}}-DOPA]] (levodopa), but with opposite [[chirality (chemistry)|chirality]]. [[levorotation|Levo-]] and [[dextrorotation|dextro-]] rotation refer to a molecule's ability to rotate planes of [[polarized light]] in one or the other direction. Whereas {{sm|l}}-DOPA is moderately effective in the [[therapy|treatment]] of [[Parkinson's disease]] (PD) and [[ |
'''{{sm|d}}-DOPA''' ('''{{sm|d}}'''-3,4-'''d'''ihydr'''o'''xy'''p'''henyl'''a'''lanine; '''dextrodopa''') is similar to [[L-DOPA|{{sm|l}}-DOPA]] (levodopa), but with opposite [[chirality (chemistry)|chirality]]. [[levorotation|Levo-]] and [[dextrorotation|dextro-]] rotation refer to a molecule's ability to rotate planes of [[polarized light]] in one or the other direction. Whereas {{sm|l}}-DOPA is moderately effective in the [[therapy|treatment]] of [[Parkinson's disease]] (PD) and [[dopamine-responsive dystonia]] (DRD) by stimulating the production of dopamine in the brain, {{sm|d}}-DOPA is [[biologically]] inactive. |
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==See also== |
==See also== |
Revision as of 14:31, 3 June 2022
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Names | |
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IUPAC name
(2R)-2-Amino-3-(3,4-dihydroxyphenyl)propanoic acid
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Identifiers | |
3D model (JSmol)
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ChemSpider | |
ECHA InfoCard | 100.024.858 |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C9H11NO4 | |
Molar mass | 197.19 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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d-DOPA (d-3,4-dihydroxyphenylalanine; dextrodopa) is similar to l-DOPA (levodopa), but with opposite chirality. Levo- and dextro- rotation refer to a molecule's ability to rotate planes of polarized light in one or the other direction. Whereas l-DOPA is moderately effective in the treatment of Parkinson's disease (PD) and dopamine-responsive dystonia (DRD) by stimulating the production of dopamine in the brain, d-DOPA is biologically inactive.
See also
- l-DOPA (Levodopa; Sinemet, Parcopa, Atamet, Stalevo, Madopar, Prolopa, etc.)
- l-DOPS (Droxidopa)
- Methyldopa (Aldomet, Apo-Methyldopa, Dopamet, Novomedopa, etc.)
- Dopamine (Intropan, Inovan, Revivan, Rivimine, Dopastat, Dynatra, etc.)
- Norepinephrine (Noradrenaline; Levophed, etc.)
- Epinephrine (Adrenaline; Adrenalin, EpiPen, Twinject, etc.)
References