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== Introduction ==
== Introduction ==
Dr. Jessica Connelly is a Professor of Psychology and the [[Principal investigator|Principal Investigator]] (PI) of her lab at the [[University of Virginia]]<ref>{{Cite web |title=UVA Psychology |url=https://psychology.as.virginia.edu/people/profile/jc2dg}}</ref>. Dr. Connelly's research studies different [[Phenotype|phenotypes]] and human diseases on both the [[Genetics|genetic]] and [[Epigenetics|epigenetic]] level.<ref name=":1">{{Cite web |date=24 Apr 2024 |title=Jessica Connelly, PhD |url=https://www.conjugate.blog/figures/episode-31-jessica-connelly-phd |website=Conjugate: Illustration and Science Blog}}</ref>
Dr. Jessica Connelly is a Professor of Psychology at the [[University of Virginia]]<ref>{{Cite web |title=UVA Psychology |url=https://psychology.as.virginia.edu/people/profile/jc2dg}}</ref>. Dr. Connelly's research studies different [[Phenotype|phenotypes]] and human diseases on both the [[Genetics|genetic]] and [[Epigenetics|epigenetic]] level.<ref name=":1">{{Cite web |date=24 Apr 2024 |title=Jessica Connelly, PhD |url=https://www.conjugate.blog/figures/episode-31-jessica-connelly-phd |website=Conjugate: Illustration and Science Blog}}</ref>


== Education ==
== Education ==
Line 8: Line 8:


== Major Contributions ==
== Major Contributions ==
⚫
Dr. Connelly’s lab studies [[oxytocin]], a [[neuropeptide]], and its receptor<ref name=":1" />. Dr. Connelly focuses on [[DNA methylation]] of the oxytocin receptor, and how individual differences contribute to differences in behavior<ref name=":1" />. Her research has demonstrated that [[Biomarker|blood biomarker]] can be used to estimate gene methylation and transcription state in the brain in an animal model, and that increased DNA methylation leads to decreased gene expression in human brains<ref name=":1" />. Dr. Connelly’s lab is also one of few that work with [[Prairie vole|prairie voles]], instead of mice or rats, due to their [[social monogamy]] that is so rare in rodents, but parallel with humans<ref name=":1" /><ref>{{Cite web |date=16 Oct 2019 |title=Parents’ behavior influences bonding hormone oxytocin in babies |url=https://www.mpg.de/14010648/1016-nepf-132884-mothers-behavior-influences-bonding-hormone-oxytocin-in-babies}}</ref><ref>{{Cite web |last=P |first=Andrea |date=5 Nov 2019 |title=A Mother’s Behavior Could Epigenetically Impact Infant Oxytocin Levels |url=https://www.whatisepigenetics.com/a-mothers-behavior-could-epigenetically-impact-infant-oxytocin-levels/#google_vignette}}</ref><ref>{{Cite web |last=Kirkpatrick |first=Bailey |date=17 Feb 2015 |title=DNA Methylation Could Explain How People Respond to Fear and Anger |url=https://www.whatisepigenetics.com/dna-methylation-could-explain-how-people-respond-to-fear-and-anger/}}</ref><ref>{{Cite web |title=UVa part of research that helps ID women at risk of postpartum depression |url=https://dailyprogress.com/news/local/uva-part-of-research-that-helps-id-women-at-risk-of-postpartum-depression/article_712e5b54-396d-11e5-a7e7-93ffcd16cc5d.html}}</ref><ref>{{Cite web |last=Carter |first=Sue |date=9 Oct 2017 |title=Oxytocin and the Biology of Love: Too Much of a Good Thing? |url=https://www.medscape.com/viewarticle/879325}}</ref><ref>{{Cite web |last=Campbell |first=Kate |date=2016 |title=What can voles tell us about ourselves? |url=https://uvamagazine.org/articles/what_can_voles_tell_us_about_ourselves}}</ref><ref>{{Cite web |last=Carter |first=Sue |title=Birth and Beyond: The far reaching influence of Oxytocin |url=https://researchfeatures.com/wp-content/uploads/2018/07/Sue-Carter.pdf}}</ref><ref>{{Cite web |date=22 Oct 2019 |title=Mothers' behavior can have substantial impact in developing oxytocin |url=https://www.deccanchronicle.com/lifestyle/health-and-wellbeing/221019/mothers-behaviour-can-have-substantial-impact-in-developing-oxytocin.html}}</ref><ref>{{Cite web |date=28 Jul 2015 |title=Blood marker spots women at risk for postpartum depression |url=https://www.business-standard.com/article/pti-stories/blood-marker-spots-women-at-risk-for-postpartum-depression-115072800463_1.html}}</ref><ref>{{Cite web |date=20 Oct 2019 |title=Mothers' behavior influences bonding hormone in babies study |url=https://www.aninews.in/news/lifestyle/parenting/mothers-behaviour-influences-bonding-hormone-in-babies-study20191020144911/}}</ref><ref>{{Cite web |date=17 Feb 2023 |title=C-section birth impacts prairie vole bonding |url=https://www.miragenews.com/c-section-birth-impacts-prairie-vole-bonding-is-949414/}}</ref><ref>{{Cite web |date=21 Oct 2019 |title=Here's how mothers' behaviour influences bonding hormone in babies |url=https://www.hindustantimes.com/sex-and-relationships/here-s-how-mothers-behaviour-influences-bonding-hormone-in-babies/story-BI3TVq96OKo6GGQu9217jI.html}}</ref><ref>{{Cite web |last=Stanford |first=Kaitlin |date=29 Jul 2015 |title=Could a simple test predict postpartum depression in mothers? |url=https://www.bustle.com/articles/100535-postpartum-depression-could-be-predicted-by-a-blood-marker-study-says-here-are-6-other}}</ref><ref>{{Cite web |date=29 Oct 2019 |title=Mothers' behavior can greatly influence child's oxytocin system: Study |url=https://www.thehansindia.com/life-style/relationship/mothers-behaviour-can-greatly-influence-childs-oxytocin-system-study-574568}}</ref><ref>{{Cite web |date=29 Jul 2015 |title=Oxytocin Receptor May Influence Postpartum Depression, Be Potential Biomarker |url=https://www.medicaldaily.com/oxytocin-receptor-may-influence-postpartum-depression-be-potential-biomarker-345252}}</ref><ref>{{Cite web |last=Wijlaars |first=Linda |date=3 Aug 2015 |title=Epigenetic variation predicts post-natal depression |url=https://www.progress.org.uk/epigenetic-variation-predicts-post-natal-depression/}}</ref><ref>{{Cite web |last=Doctor |first=Rina Marie |date=29 Jul 2015 |title=Marker Found In Human Blood May Help Identify Postpartum Depression Risk |url=https://www.techtimes.com/articles/72739/20150729/marker-found-in-human-blood-may-help-identify-postpartum-depression-risk.htm}}</ref><ref>{{Cite web |last=Yasinski |first=Emma |date=1 Sep 2023 |title=Parental care may sculpt brain development in prairie voles |url=https://www.thetransmitter.org/neurodevelopment/parental-care-may-sculpt-brain-development-in-prairie-voles/}}</ref><ref>{{Cite web |date=18 Dec 2010 |title=Autism Speaks Grants to Fund Epigenetic Studies |url=https://www.genomeweb.com/archive/autism-speaks-grants-fund-epigenetic-studies#.ZimOvOzMJpQ}}</ref><ref>{{Cite web |last=Anderson |first=Kate |date=24 Oct 2015 |title=Parents' behavior can have substantial impact on developing oxytocin systems in babies |url=https://www.news-medical.net/news/20191024/Parents-behavior-can-have-substantial-impact-on-developing-oxytocin-systems-in-babies.aspx}}</ref><ref>{{Cite web |date=2009 |title=Possible epigenetic cause for oxytocin insensitivity in autism |url=https://www.futuremedicine.com/doi/pdfplus/10.2217/epi.09.41}}</ref><ref>{{Cite web |date=18 Nov 2019 |title=Mothers’ behaviour influences bonding hormone oxytocin in babies |url=https://www.ogpnews.com/2019/11/mothers-behaviour-influences-bonding-hormone-oxytocin-in-babies/44368}}</ref><ref>{{Cite web |date=25 Oct 2019 |title=Parents' Behavior can Influence Bonding Hormone Oxytocin in Babies |url=https://www.medindia.net/news/parents-behavior-can-influence-bonding-hormone-oxytocin-in-babies-191111-1.htm#google_vignette}}</ref><ref>{{Cite web |date=30 Mar 2015 |title=Study: Hormone Level Predicts How the Brain Processes Social Information |url=https://www.technology.org/2015/03/30/study-hormone-level-predicts-how-the-brain-processes-social-information/}}</ref><ref>{{Cite web |last=Samarrai |first=Farris |date=30 Mar 2015 |title=Hormone level predicts how the brain processes social information |url=https://medicalxpress.com/news/2015-03-hormone-brain-social.html#google_vignette}}</ref><ref>{{Cite web |date=19 Oct 2015 |title=Sex/gender in autism |url=https://www.spectrumnews.org/features/legacy-special-reports/sexgender-in-autism/?format=pdf}}</ref><ref>{{Cite web |title=Postpartum Depression May Be Predicted with a Blood Test |url=https://clubmother.com/articles/7142-postpartum-depression-may-be-predicted-with-a-blood-test/}}</ref>.
Dr. Connelly’s lab studies [[oxytocin]], a [[neuropeptide]], and its receptor<ref name=":1" />. Dr. Connelly focuses on [[DNA methylation]] of the oxytocin receptor, and how individual differences contribute to differences in behavior<ref name=":1" />. Her research has uncovered two major topics in this field, including proof of a [[Biomarker|blood biomarker]] for level of brain methylation and transcription state in an animal model, and proof that increased DNA methylation leads to decreased gene expression in human brains<ref name=":1" />. Dr. Connelly’s lab is also one of few that work with [[Prairie vole|prairie voles]], instead of mice or rats, due to their [[social monogamy]] that is so rare in rodents, but parallel with humans<ref name=":1" />.

⚫
<ref>{{Cite web |date=16 Oct 2019 |title=Parents’ behavior influences bonding hormone oxytocin in babies |url=https://www.mpg.de/14010648/1016-nepf-132884-mothers-behavior-influences-bonding-hormone-oxytocin-in-babies}}</ref><ref>{{Cite web |last=P |first=Andrea |date=5 Nov 2019 |title=A Mother’s Behavior Could Epigenetically Impact Infant Oxytocin Levels |url=https://www.whatisepigenetics.com/a-mothers-behavior-could-epigenetically-impact-infant-oxytocin-levels/#google_vignette}}</ref><ref>{{Cite web |last=Kirkpatrick |first=Bailey |date=17 Feb 2015 |title=DNA Methylation Could Explain How People Respond to Fear and Anger |url=https://www.whatisepigenetics.com/dna-methylation-could-explain-how-people-respond-to-fear-and-anger/}}</ref><ref>{{Cite web |title=UVa part of research that helps ID women at risk of postpartum depression |url=https://dailyprogress.com/news/local/uva-part-of-research-that-helps-id-women-at-risk-of-postpartum-depression/article_712e5b54-396d-11e5-a7e7-93ffcd16cc5d.html}}</ref><ref>{{Cite web |last=Carter |first=Sue |date=9 Oct 2017 |title=Oxytocin and the Biology of Love: Too Much of a Good Thing? |url=https://www.medscape.com/viewarticle/879325}}</ref><ref>{{Cite web |last=Campbell |first=Kate |date=2016 |title=What can voles tell us about ourselves? |url=https://uvamagazine.org/articles/what_can_voles_tell_us_about_ourselves}}</ref><ref>{{Cite web |last=Carter |first=Sue |title=Birth and Beyond: The far reaching influence of Oxytocin |url=https://researchfeatures.com/wp-content/uploads/2018/07/Sue-Carter.pdf}}</ref><ref>{{Cite web |date=22 Oct 2019 |title=Mothers' behavior can have substantial impact in developing oxytocin |url=https://www.deccanchronicle.com/lifestyle/health-and-wellbeing/221019/mothers-behaviour-can-have-substantial-impact-in-developing-oxytocin.html}}</ref><ref>{{Cite web |date=28 Jul 2015 |title=Blood marker spots women at risk for postpartum depression |url=https://www.business-standard.com/article/pti-stories/blood-marker-spots-women-at-risk-for-postpartum-depression-115072800463_1.html}}</ref><ref>{{Cite web |date=20 Oct 2019 |title=Mothers' behavior influences bonding hormone in babies study |url=https://www.aninews.in/news/lifestyle/parenting/mothers-behaviour-influences-bonding-hormone-in-babies-study20191020144911/}}</ref><ref>{{Cite web |date=17 Feb 2023 |title=C-section birth impacts prairie vole bonding |url=https://www.miragenews.com/c-section-birth-impacts-prairie-vole-bonding-is-949414/}}</ref><ref>{{Cite web |date=21 Oct 2019 |title=Here's how mothers' behaviour influences bonding hormone in babies |url=https://www.hindustantimes.com/sex-and-relationships/here-s-how-mothers-behaviour-influences-bonding-hormone-in-babies/story-BI3TVq96OKo6GGQu9217jI.html}}</ref><ref>{{Cite web |last=Stanford |first=Kaitlin |date=29 Jul 2015 |title=Could a simple test predict postpartum depression in mothers? |url=https://www.bustle.com/articles/100535-postpartum-depression-could-be-predicted-by-a-blood-marker-study-says-here-are-6-other}}</ref><ref>{{Cite web |date=29 Oct 2019 |title=Mothers' behavior can greatly influence child's oxytocin system: Study |url=https://www.thehansindia.com/life-style/relationship/mothers-behaviour-can-greatly-influence-childs-oxytocin-system-study-574568}}</ref><ref>{{Cite web |date=29 Jul 2015 |title=Oxytocin Receptor May Influence Postpartum Depression, Be Potential Biomarker |url=https://www.medicaldaily.com/oxytocin-receptor-may-influence-postpartum-depression-be-potential-biomarker-345252}}</ref><ref>{{Cite web |last=Wijlaars |first=Linda |date=3 Aug 2015 |title=Epigenetic variation predicts post-natal depression |url=https://www.progress.org.uk/epigenetic-variation-predicts-post-natal-depression/}}</ref><ref>{{Cite web |last=Doctor |first=Rina Marie |date=29 Jul 2015 |title=Marker Found In Human Blood May Help Identify Postpartum Depression Risk |url=https://www.techtimes.com/articles/72739/20150729/marker-found-in-human-blood-may-help-identify-postpartum-depression-risk.htm}}</ref><ref>{{Cite web |last=Yasinski |first=Emma |date=1 Sep 2023 |title=Parental care may sculpt brain development in prairie voles |url=https://www.thetransmitter.org/neurodevelopment/parental-care-may-sculpt-brain-development-in-prairie-voles/}}</ref><ref>{{Cite web |date=18 Dec 2010 |title=Autism Speaks Grants to Fund Epigenetic Studies |url=https://www.genomeweb.com/archive/autism-speaks-grants-fund-epigenetic-studies#.ZimOvOzMJpQ}}</ref><ref>{{Cite web |last=Anderson |first=Kate |date=24 Oct 2015 |title=Parents' behavior can have substantial impact on developing oxytocin systems in babies |url=https://www.news-medical.net/news/20191024/Parents-behavior-can-have-substantial-impact-on-developing-oxytocin-systems-in-babies.aspx}}</ref><ref>{{Cite web |date=2009 |title=Possible epigenetic cause for oxytocin insensitivity in autism |url=https://www.futuremedicine.com/doi/pdfplus/10.2217/epi.09.41}}</ref><ref>{{Cite web |date=18 Nov 2019 |title=Mothers’ behaviour influences bonding hormone oxytocin in babies |url=https://www.ogpnews.com/2019/11/mothers-behaviour-influences-bonding-hormone-oxytocin-in-babies/44368}}</ref><ref>{{Cite web |date=25 Oct 2019 |title=Parents' Behavior can Influence Bonding Hormone Oxytocin in Babies |url=https://www.medindia.net/news/parents-behavior-can-influence-bonding-hormone-oxytocin-in-babies-191111-1.htm#google_vignette}}</ref><ref>{{Cite web |date=30 Mar 2015 |title=Study: Hormone Level Predicts How the Brain Processes Social Information |url=https://www.technology.org/2015/03/30/study-hormone-level-predicts-how-the-brain-processes-social-information/}}</ref><ref>{{Cite web |last=Samarrai |first=Farris |date=30 Mar 2015 |title=Hormone level predicts how the brain processes social information |url=https://medicalxpress.com/news/2015-03-hormone-brain-social.html#google_vignette}}</ref><ref>{{Cite web |date=19 Oct 2015 |title=Sex/gender in autism |url=https://www.spectrumnews.org/features/legacy-special-reports/sexgender-in-autism/?format=pdf}}</ref><ref>{{Cite web |title=Postpartum Depression May Be Predicted with a Blood Test |url=https://clubmother.com/articles/7142-postpartum-depression-may-be-predicted-with-a-blood-test/}}</ref>

Revision as of 15:42, 29 April 2024

Introduction

Dr. Jessica Connelly is a Professor of Psychology at the University of Virginia[1]. Dr. Connelly's research studies different phenotypes and human diseases on both the genetic and epigenetic level.[2]

Education

Dr. Jessica Connelly earned her Bachelor’s of Science (BS) in Chemistry, with a focus in Biochemistry, at Stockton College of New Jersey, and first began her research journey as a graduate student in 1997 under Dr. John Luchessi[3]. During this time, she was introduced to epigenetics, studying dosage compensation of Drosophila melanogaster;[2] epigenetics would come to be her field of choice when starting her own lab at the University of Virginia[3]. In 1999, she went on to start her PhD in Genetics at State University of New York at Stony Brook, where she studied under a yeast epigeneticist, Dr. Rolf Sternglanz[3]. In Sternglanz’s lab, Connelly’s thesis focused on chromatin compaction regulation transcription in histone code[3]. After completing her PhD in 2004, she earned her Postdoctoral degree at Duke University’s Center for Human Genetics, during which time she focused on human genetics and genomics[3]. Her mentors during her Postdoctoral degree at Duke University were statistical geneticist, Dr. Elizabeth Hauser, and human genomicist, Dr. Simon Gregory[3].

Major Contributions

Dr. Connelly’s lab studies oxytocin, a neuropeptide, and its receptor[2]. Dr. Connelly focuses on DNA methylation of the oxytocin receptor, and how individual differences contribute to differences in behavior[2]. Her research has demonstrated that blood biomarker can be used to estimate gene methylation and transcription state in the brain in an animal model, and that increased DNA methylation leads to decreased gene expression in human brains[2]. Dr. Connelly’s lab is also one of few that work with prairie voles, instead of mice or rats, due to their social monogamy that is so rare in rodents, but parallel with humans[2][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30].

  1. ^ "UVA Psychology".
  2. ^ a b c d e f "Jessica Connelly, PhD". Conjugate: Illustration and Science Blog. 24 Apr 2024.
  3. ^ a b c d e f "Education".
  4. ^ "Parents' behavior influences bonding hormone oxytocin in babies". 16 Oct 2019.
  5. ^ P, Andrea (5 Nov 2019). "A Mother's Behavior Could Epigenetically Impact Infant Oxytocin Levels".
  6. ^ Kirkpatrick, Bailey (17 Feb 2015). "DNA Methylation Could Explain How People Respond to Fear and Anger".
  7. ^ "UVa part of research that helps ID women at risk of postpartum depression".
  8. ^ Carter, Sue (9 Oct 2017). "Oxytocin and the Biology of Love: Too Much of a Good Thing?".
  9. ^ Campbell, Kate (2016). "What can voles tell us about ourselves?".
  10. ^ Carter, Sue. "Birth and Beyond: The far reaching influence of Oxytocin" (PDF).
  11. ^ "Mothers' behavior can have substantial impact in developing oxytocin". 22 Oct 2019.
  12. ^ "Blood marker spots women at risk for postpartum depression". 28 Jul 2015.
  13. ^ "Mothers' behavior influences bonding hormone in babies study". 20 Oct 2019.
  14. ^ "C-section birth impacts prairie vole bonding". 17 Feb 2023.
  15. ^ "Here's how mothers' behaviour influences bonding hormone in babies". 21 Oct 2019.
  16. ^ Stanford, Kaitlin (29 Jul 2015). "Could a simple test predict postpartum depression in mothers?".
  17. ^ "Mothers' behavior can greatly influence child's oxytocin system: Study". 29 Oct 2019.
  18. ^ "Oxytocin Receptor May Influence Postpartum Depression, Be Potential Biomarker". 29 Jul 2015.
  19. ^ Wijlaars, Linda (3 Aug 2015). "Epigenetic variation predicts post-natal depression".
  20. ^ Doctor, Rina Marie (29 Jul 2015). "Marker Found In Human Blood May Help Identify Postpartum Depression Risk".
  21. ^ Yasinski, Emma (1 Sep 2023). "Parental care may sculpt brain development in prairie voles".
  22. ^ "Autism Speaks Grants to Fund Epigenetic Studies". 18 Dec 2010.
  23. ^ Anderson, Kate (24 Oct 2015). "Parents' behavior can have substantial impact on developing oxytocin systems in babies".
  24. ^ "Possible epigenetic cause for oxytocin insensitivity in autism". 2009.
  25. ^ "Mothers' behaviour influences bonding hormone oxytocin in babies". 18 Nov 2019.
  26. ^ "Parents' Behavior can Influence Bonding Hormone Oxytocin in Babies". 25 Oct 2019.
  27. ^ "Study: Hormone Level Predicts How the Brain Processes Social Information". 30 Mar 2015.
  28. ^ Samarrai, Farris (30 Mar 2015). "Hormone level predicts how the brain processes social information".
  29. ^ "Sex/gender in autism". 19 Oct 2015.
  30. ^ "Postpartum Depression May Be Predicted with a Blood Test".
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