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==Career and research==
==Career and research==
For her postgraduate work, Lakadamyali worked as a [[postdoctoral researcher]] under Prof [[Jeff W. Lichtman|Jeff Lichtman]] at the Center for
For his postgraduate work, Jungmann worked as a [[postdoctoral researcher]] under Peng Yin and William M Shih at the [[Wyss Institute for Biologically Inspired Engineering]] at [[Harvard University]].
[[Brain science|Brain Science]] at Harvard University, MA, USA.<ref>{{cite journal|title=3D Multicolor Super-Resolution Imaging Offers Improved Accuracy in Neuron Tracing &#124; PLOS ONE |publisher=Journals.plos.org |date=2012-01-24 |doi=10.1371/journal.pone.0030826 |doi-access=free |pmid=22292051 |last1=Lakadamyali |first1=M. |last2=Babcock |first2=H. |last3=Bates |first3=M. |last4=Zhuang |first4=X. |last5=Lichtman |first5=J. |journal=PLOS ONE |volume=7 |issue=1 |pages=e30826 |pmc=3265519 }}</ref>
Between 2010 and 2016, Lakadamyali was a Group Leader at [[ICFO|ICFO - The Institute of Photonic Sciences]] in [[Barcelona]], [[Spain]], holding a Junior (2010-2015) and Senior (2015-2016) Group Leader position, respectively. Her group's superresolution microscopy study investigating the genome gained widespread attention. It reveals that our genome needs to be regularly packaged and links these packaging differences to stem cell state.<ref>{{Cite journal |last1=Ricci |first1=Maria Aurelia |last2=Manzo |first2=Carlo |last3=García-Parajo |first3=María Filomena |last4=Lakadamyali |first4=Melike |last5=Pia Cosma |first5=Maria |date=12 March 2015 |title=Chromatin Fibers Are Formed by Heterogeneous Groups of Nucleosomes In Vivo |journal=[[Cell (journal)|Cell]] |volume=160 |issue=6 |pages=1145–1158 |doi=10.1016/j.cell.2015.01.054|doi-access=free |pmid=25768910 |hdl=10803/298724 |hdl-access=free }}</ref><ref>{{cite web|url=https://www.youtube.com/watch?v=5KSr-giy8qo |title=Nucleosome clutches / Cell, March 12, 2015 (Vol. 160, Issue 6) |publisher=YouTube |date= |accessdate=2023-09-04}}</ref><ref>{{cite web|url=https://www.crg.eu/en/news/super-resolution-microscopes-reveal-link-between-genome-packaging-and-cell-pluripotency |title=Centre for Genomic Regulation Website |publisher=Crg.eu |date=2015-03-12 |accessdate=2023-09-04}}</ref>
Between 2010 and 2016, Lakadamyali was a Group Leader at [[ICFO|ICFO - The Institute of Photonic Sciences]] in [[Barcelona]], [[Spain]], holding a Junior (2010-2015) and Senior (2015-2016) Group Leader position, respectively. Her group's superresolution microscopy study investigating the genome gained widespread attention. It reveals that our genome needs to be regularly packaged and links these packaging differences to stem cell state.<ref>{{Cite journal |last1=Ricci |first1=Maria Aurelia |last2=Manzo |first2=Carlo |last3=García-Parajo |first3=María Filomena |last4=Lakadamyali |first4=Melike |last5=Pia Cosma |first5=Maria |date=12 March 2015 |title=Chromatin Fibers Are Formed by Heterogeneous Groups of Nucleosomes In Vivo |journal=[[Cell (journal)|Cell]] |volume=160 |issue=6 |pages=1145–1158 |doi=10.1016/j.cell.2015.01.054|doi-access=free |pmid=25768910 |hdl=10803/298724 |hdl-access=free }}</ref><ref>{{cite web|url=https://www.youtube.com/watch?v=5KSr-giy8qo |title=Nucleosome clutches / Cell, March 12, 2015 (Vol. 160, Issue 6) |publisher=YouTube |date= |accessdate=2023-09-04}}</ref><ref>{{cite web|url=https://www.crg.eu/en/news/super-resolution-microscopes-reveal-link-between-genome-packaging-and-cell-pluripotency |title=Centre for Genomic Regulation Website |publisher=Crg.eu |date=2015-03-12 |accessdate=2023-09-04}}</ref>

Revision as of 16:21, 7 June 2024

Ralf Jungmann
NationalityGerman
Alma mater
Known forDNA-PAINT
Scientific career
FieldsSuper-Resolution Microscopy, DNA Nanotechnology, Biophysics, Single Molecule Experiments
Institutions
ThesisDNA origami as a molecular platform for bionanotechnology (2010)
Doctoral advisorFriedrich Simmel
WebsiteJungmann Lab

Ralf Jungmann is a German physicist and Full Professor (Physics) and Chair for Molecular Physics of Life at the Ludwig Maximilian University of Munich, Germany. He is known for his contributions to the development of super-resolution microscopy techniques. In particular, he is known for his work on DNA-PAINT, a super-resolution technique that uses short DNA strands to label and locate specific molecules within a sample with high precision. This technique has important applications in the study of biological systems and has been used to uncover new insights into the structure and function of cells.

Education

Between 2001 and 2006, Jungmann pursued a degree in Physics at Saarland University and the University of California, Santa Barbara. During his time at the latter institution, he conducted his Diploma thesis under the guidance of Paul K. Hansma. Subsequently, from 2007 to 2010, he completed his Ph.D. in Physics at Technical University of Munich, where he worked in the laboratory of Friedrich Simmel.

Career and research

For his postgraduate work, Jungmann worked as a postdoctoral researcher under Peng Yin and William M Shih at the Wyss Institute for Biologically Inspired Engineering at Harvard University.

Between 2010 and 2016, Lakadamyali was a Group Leader at ICFO - The Institute of Photonic Sciences in Barcelona, Spain, holding a Junior (2010-2015) and Senior (2015-2016) Group Leader position, respectively. Her group's superresolution microscopy study investigating the genome gained widespread attention. It reveals that our genome needs to be regularly packaged and links these packaging differences to stem cell state.[1][2][3]

In 2017, Lakadamyali returned to the United States to work as an Assistant Professor of Physiology and of Cell and Developmental Biology (secondary) at the University of Pennsylvania in Philadelphia.

In 2020, Lakadamyali was promoted to Associate Professor of Physiology and in 2024 she was promoted to Full Professor.

Lakadamyali's area of research is focused on examining biology at the level of its macromolecular machines. She aims to obtain a quantitative and biophysical comprehension of how these machines propel critical cell biological processes.[4][5][6] Hence, she is also involved in designing sophisticated microscopy techniques that strive to surmount the current limitations of existing methods, thereby enabling them to observe the macromolecular machinery of the cell in motion with superior spatiotemporal resolution.[7][8][9]

Lakadamyali is a well-known microscopist and biophysicist. Hence, she is frequently invited to speak at workshops[10][11] and conferences[12][13][14] in the field.

Since 2019, Lakadamyali has been a Reviewing Editor (Cell Biology) at eLife.[15]

Awards and honours

References

  1. ^ Ricci, Maria Aurelia; Manzo, Carlo; García-Parajo, María Filomena; Lakadamyali, Melike; Pia Cosma, Maria (12 March 2015). "Chromatin Fibers Are Formed by Heterogeneous Groups of Nucleosomes In Vivo". Cell. 160 (6): 1145–1158. doi:10.1016/j.cell.2015.01.054. hdl:10803/298724. PMID 25768910.
  2. ^ "Nucleosome clutches / Cell, March 12, 2015 (Vol. 160, Issue 6)". YouTube. Retrieved 2023-09-04.
  3. ^ "Centre for Genomic Regulation Website". Crg.eu. 2015-03-12. Retrieved 2023-09-04.
  4. ^ "Super resolution microscopy reveals how elongating RNA polymerase II and nascent RNA interact with nucleosome clutches | Nucleic Acids Research | Oxford Academic". Academic.oup.com. Retrieved 2023-09-04.
  5. ^ Gómez-García, Pablo Aurelio; Portillo-Ledesma, Stephanie; Neguembor, Maria Victoria; Pesaresi, Martina; Oweis, Walaa; Rohrlich, Talia; Wieser, Stefan; Meshorer, Eran; Schlick, Tamar; Cosma, Maria Pia; Lakadamyali, Melike (2021). "Mesoscale Modeling and Single-Nucleosome Tracking Reveal Remodeling of Clutch Folding and Dynamics in Stem Cell Differentiation". Cell Reports. 34 (2). doi:10.1016/j.celrep.2020.108614. PMC 7842188. PMID 33440158.
  6. ^ Lakadamyali, Melike; Cosma, Maria Pia (2020). "Visualizing the genome in high resolution challenges our textbook understanding". Nature Methods. 17 (4): 371–379. doi:10.1038/s41592-020-0758-3. hdl:10230/43808. ISSN 1548-7105. PMID 32123395. S2CID 211729851.
  7. ^ "Melike Lakadamyali | Faculty | About Us | Perelman School of Medicine | Perelman School of Medicine at the University of Pennsylvania". Med.upenn.edu. Retrieved 2023-09-04.
  8. ^ Bond, Charles; Santiago-Ruiz, Adriana N.; Tang, Qing; Lakadamyali, Melike (2022-01-20). "Technological advances in super-resolution microscopy to study cellular processes". Molecular Cell. 82 (2): 315–332. doi:10.1016/j.molcel.2021.12.022. PMC 8852216. PMID 35063099.
  9. ^ Hugelier, Siewert; Colosi, P.L.; Lakadamyali, Melike (2023-05-09). "Quantitative Single-Molecule Localization Microscopy". Annual Review of Biophysics. 52 (1): 139–160. doi:10.1146/annurev-biophys-111622-091212. ISSN 1936-122X. PMID 37159293.
  10. ^ "In situ structural biology: from cryo-EM to multi-scale modelling – Course and Conference Office". Embl.org. Retrieved 2023-09-04.
  11. ^ Home. "22nd Single Molecule Workshop". PicoQuant. Retrieved 2023-09-04.
  12. ^ "JCS2023: Imaging Cell Dynamics - The Company of Biologists". Biologists.com. Retrieved 2023-09-04.
  13. ^ "Seeing is Believing – Imaging the Molecular Processes of Life – Course and Conference Office". Embl.org. 2019-10-12. Retrieved 2023-09-04.
  14. ^ "Genome Organization & Nuclear Function 2022 | CSHL". meetings.cshl.edu. Retrieved 2023-09-04.
  15. ^ "Editors for Cell Biology". eLife. Retrieved 2023-09-04.
  16. ^ https://erc.europa.eu/sites/default/files/document/file/erc_2015_stg_results_ls.pdf
  17. ^ https://cordis.europa.eu/project/id/680241
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