Jump to content

Cerebral venous sinus thrombosis: Difference between revisions

From Wikipedia, the free encyclopedia
Browse history interactively
← Previous editNext edit →
Content deleted Content added
VisualWikitext
→Epidemiology: emedicine additions
→Investigations: Added an image
Line 43: Line 43:


;CT, MRI and angiography
;CT, MRI and angiography
[[Image:Sagital sinus thrombus.JPG|thumb|rigtht|200px| CT Scan showing a filling defect in the Sagital sinus]]
There are various [[neuroimaging]] investigations that may detect cerebral sinus thrombosis. [[Cerebral oedema]] and venous infarction may be apparent on any modality, but for the detection of the thrombus itself, the most commonly used tests are [[computed tomography]] (CT) and [[magnetic resonance imaging]] (MRI), both using various types of radiocontrast to perform a [[venogram]] and visualise the veins around the brain.<ref name=Stam2005/>
There are various [[neuroimaging]] investigations that may detect cerebral sinus thrombosis. [[Cerebral oedema]] and venous infarction may be apparent on any modality, but for the detection of the thrombus itself, the most commonly used tests are [[computed tomography]] (CT) and [[magnetic resonance imaging]] (MRI), both using various types of radiocontrast to perform a [[venogram]] and visualise the veins around the brain.<ref name=Stam2005/>


Revision as of 11:00, 25 April 2008

Cerebral venous sinus thrombosis
SpecialtyNeurology, circulatory system Edit this on Wikidata

Cerebral venous sinus thrombosis is a rare form of thrombosis (a blood clot) affecting the dural venous sinuses which drain blood from the brain. Symptoms may include headache, abnormal vision, any of the symptoms of stroke such as weakness of the face and limbs on one side of the body, and seizures. Treatment is with anticoagulants (medication that suppresses blood clotting). The disease may be complicated by raised intracranial pressure, which may warrant surgical intervention such as the placement of a shunt.[1] There are several other terms for the condition, such as cerebral venous and sinus thrombosis, (superior) sagittal sinus thrombosis, dural sinus thrombosis and intracranial venous thrombosis.

Signs and symptoms

Clinical presentation

Nine in ten people with sinus thrombosis have a headache; this tends to worsen over the period of several days, but may also develop suddenly (thunderclap headache).[1] The headache may be the only symptom of cerebral venous sinus thrombosis.[2] Many patients have symptoms of stroke: inability to move one or more limbs, weakness on one side of the face or difficulty speaking. This does not necessarily affect one side of the body as in the more common "arterial" stroke.[1]

40% of all patients have seizures, although it is commoner still in women before and after birth.[3]), mostly affecting only one part of the body and unilateral but often generalised and sometimes leading to status epilepticus (persistent seizure activity for a long period of time).[1]

In the elderly, many of the aforementioned symptoms may not occur. Common symptoms in the elderly with this condition are otherwise unexplained changes in mental status and a depressed level of consciousness.[4]

The intracranial pressure (pressure around the brain) may rise, causing papilloedema (swelling of the optic disc) which may be experienced as visual obscurations. In severely raised intracranial pressure, the level of consciousness is decreased, the blood pressure rises, the heart rate falls and the patient assumes an abnormal posture.[1]

Risk factors

Cerebral venous sinus thrombosis is more common in particular situations. 85% of patients have at least one of these risk factors:[1]

Diagnosis

Investigations

The diagnosis may be suspected on the basis of the symptoms, for example the combination of headache, signs of raised intercranial pressure and focal neurological abnormalities, or when alternative causes of headache and neurological abnormalities, such as a subarachnoid hemorrhage, have been excluded.[1]

CT, MRI and angiography
CT Scan showing a filling defect in the Sagital sinus

There are various neuroimaging investigations that may detect cerebral sinus thrombosis. Cerebral oedema and venous infarction may be apparent on any modality, but for the detection of the thrombus itself, the most commonly used tests are computed tomography (CT) and magnetic resonance imaging (MRI), both using various types of radiocontrast to perform a venogram and visualise the veins around the brain.[1]

Computed tomography, with radiocontrast in the venous phase (CT venography or CTV), has a detection rate that in some regards exceeds that of MRI. The test involves injection into a vein (usually in the arm) of a radioopaque substance, and time is allowed for the bloodstream to carry it to the cerebral veins - at which point the scan is performed. It has a sensitivity of 75-100% (it detects 75-100% of all clots present), and a specificity of 81-100% (it would be incorrectly positive in 0-19%). In the first two weeks, the "empty delta sign" may be observed (in later stages, this sign may disappear).[5]

Magnetic resonance venography employs the same principles, but uses MRI as a scanning modality. MRI has the advantage of being better at detecting damage to the brain itself as a result of the increased pressure on the obstructed veins, but it is not readily available in many hospitals and the interpretation may be difficult.[5]

Cerebral angiography may demonstrate smaller clots than CT or MRI, and obstructed veins may give the "corkscrew appearance".[1] This, however, requires puncture of the femoral artery with a sheath and advancing a thin tube through the blood vessels to the brain where radiocontrast is injected before X-ray images are obtained. It is therefore only performed if all other tests give unclear results or when other treatments may be administered during the same procedure.

D-dimer

A 2004 study suggested that the D-dimer blood test, already in use for the diagnosis of other forms of thrombosis, was abnormal (above 500 μg/l) in 34 out of 35 patients with cerebral sinus thrombosis, giving it a sensitivity of 97.1%, a negative predictive value of 99.6%, a specificity of 91.2%, and a positive predictive value of 55.7%. Furthermore, the level of the D-dimer correlated with the extent of the thrombosis.[6] A subsequent study, however, showed that 10% of patients with confirmed thrombosis had a normal D-dimer, and in those who had presented with only a headache 26% had a normal D-dimer. The study concludes that D-dimer is not useful in the situations where it would make the most difference, namely in lower probability cases.[7]

Further tests

In most patients, the direct cause for the cerebral sinus thrombosis is not readily apparent. Identifying a source of infection is crucial, but it is common practice to screen for various forms of thrombophilia (a propensity to form blood clots).[1]

Pathogenesis

The veins of the brain, both the superficial veins and the deep venous system, empty into the dural venous sinuses, which carry blood back to the jugular vein and thence to the heart. In cerebral venous sinus thrombosis, blood clots usually form both in the veins of the brain and the venous sinuses. The thrombosis of the veins themselves causes cerebral oedema (both vasogenic and cytotoxic oedema) through back pressure, and lead to small petechial haemorrhages that may merge into large haematomas. Thrombosis of the sinuses is the main mechanism behind the increase in intracranial pressure due to decreased resorption of cerebrospinal fluid (CSF). The condition does not lead to hydrocephalus, however, because there is no difference in pressure between various parts of the brain.[1]

Any blood clot forms due to an imbalance between coagulation (the formation of the insoluble blood protein fibrin) and fibrinolysis. The three major mechanisms for such an imbalance are enumerated in Virchow's triad: alterations in normal blood flow, injury to the blood vessel wall, and alterations in the constitution of blood (hypercoagulability). Most cases of cerebral venous sinus thrombosis are due to hypercoagulability.[1]

It is possible for the clot to break off and migrate (embolise) to the lungs, causing a pulmonary embolism.[1][3] An analysis of earlier case reports concludes that this occurs in about 10% of cases, but has a very poor prognosis.[8]

Treatment

Various studies have investigated the use of anticoagulation to suppress blood clot formation in cerebral venous sinus thrombosis. Before these trials had been conducted, there had been a concern that small areas of hemorrhage in the brain would bleed further as a result of treatment; the studies showed that this concern was unfounded. The European Federation of Neurological Societies (EFNS), in their 2006 clinical practice guideline, recommends heparin or low molecular weight heparin in the initial treatment, followed by warfarin, provided there are no other bleeding risks that would make these treatments unsuitable.[3] The duration of warfarin treatment depends on the circumstances and underlying causes of the condition. If the thrombosis developed under temporary circumstances (e.g. pregnancy), three months are regarded as sufficient. If the condition was unprovoked but there are no clear causes or a "mild" form of thrombophilia, 6 to 12 months is advised. If there is a severe underlying thrombosis disorder, warfarin treatment may need to continue indefinitely.[3]

Thrombolysis (removal of the blood clot with "clot buster" medication) has been described, either systemically by injection into a vein or directly into the clot during angiography. The 2006 EFNS guideline recommends that thrombolysis is only used in patients who deteriorate despite adequate treatment, and other causes of deterioration have been eliminated. It is unclear which drug and which mode of administration is the most effective. Bleeding into the brain and in other sites of the body is a major concern in the use of thrombolysis.[3]

Raised intracranial pressure, if severe or threatening vision, may require therapeutic lumbar puncture (removal of excessive cerebrospinal fluid), medication (acetazolamide), or neurosurgical treatment (optic nerve sheath fenestration or shunting).[1] In certain situations, anticonvulsants may be used to prevent seizures; these are focal neurological problems (e.g. inability to move a limb) and/or focal changes of the brain tissue on CT or MRI scan.[3]

Prognosis

In 2004 the first adequately large scale study on the natural history and long-term prognosis of this condition was reported; this showed that at 16 months follow-up 57.1% of patients had full recovery, 29.5%/2.9%/2.2% had respectively minor/moderate/severe symptoms or impairments, and 8.3% had died. Severe impairment or death were more likely in those aged over 37 years, male, affected by coma, mental status disorder, intracerebral hemorrhage, thrombosis of the deep cerebral venous system, central nervous system infection and cancer.[9] A subsequent systematic review of nineteen studies in 2006 showed that mortality is about 5.6% during hospitalisation and 9.4% in total, while of the survivors 88% make a total or near-total recovery. After several months, two thirds of the cases has resolution ("recanalisation") of the clot. The rate of recurrence was low (2.8%).[10]

Epidemiology

Cerebral venous sinus thrombosis is rare, with an estimated 3-4 cases per million annual incidence in adults and 7 per million incidence in children (predominantly in the newborn[3]). However, a 1995 study showed that, in Saudi Arabia, the incidence may be higher at 7 cases per 100,000.[11] Although an aged study, in 1973 Towbin described that, out of 182 autopsies, 9% had noticeable CVST.[11] 75% of cases are in women; some historical evidence suggests that the use of oral contraceptives in women is behind the disparity between the sexes.[1] In adults, the disease occurs most often in the third decade.[3]

References

  1. ^ a b c d e f g h i j k l m n o Stam J (2005). "Thrombosis of the cerebral veins and sinuses". N. Engl. J. Med. 352 (17): 1791–8. doi:10.1056/NEJMra042354. PMID 15858188.
  2. ^ Cumurciuc R, Crassard I, Sarov M, Valade D, Bousser MG (2005). "Headache as the only neurological sign of cerebral venous thrombosis: a series of 17 cases". J. Neurol. Neurosurg. Psychiatr. 76 (8): 1084–7. doi:10.1136/jnnp.2004.056275. PMID 16024884.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ^ a b c d e f g h Einhäupl K, Bousser MG, de Bruijn SF; et al. (2006). "EFNS guideline on the treatment of cerebral venous and sinus thrombosis". Eur. J. Neurol. 13 (6): 553–9. doi:10.1111/j.1468-1331.2006.01398.x. PMID 16796579. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  4. ^ Ferro JM, Canhão P, Bousser MG, Stam J, Barinagarrementeria F (2005). "Cerebral vein and dural sinus thrombosis in elderly patients". Stroke. 36 (9): 1927–32. doi:10.1161/01.STR.0000177894.05495.54. PMID 16100024.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  5. ^ a b Smith R, Hourihan MD (2007). "Investigating suspected cerebral venous thrombosis". BMJ. 334 (7597): 794–5. doi:10.1136/bmj.39154.636968.47. PMID 17431266.
  6. ^ Kosinski CM, Mull M, Schwarz M; et al. (2004). "Do normal D-dimer levels reliably exclude cerebral sinus thrombosis?". Stroke. 35 (12): 2820–5. doi:10.1161/01.STR.0000147045.71923.18. PMID 15514174. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  7. ^ Crassard I, Soria C, Tzourio C; et al. (2005). "A negative D-dimer assay does not rule out cerebral venous thrombosis: a series of seventy-three patients". Stroke. 36 (8): 1716–9. doi:10.1161/01.STR.0000173401.76085.98. PMID 16020765. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  8. ^ Diaz JM, Schiffman JS, Urban ES, Maccario M (1992). "Superior sagittal sinus thrombosis and pulmonary embolism: a syndrome rediscovered". Acta Neurol. Scand. 86 (4): 390–6. PMID 1455986.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  9. ^ Ferro JM, Canhão P, Stam J, Bousser MG, Barinagarrementeria F (2004). "Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT)". Stroke. 35 (3): 664–70. doi:10.1161/01.STR.0000117571.76197.26. PMID 14976332.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  10. ^ Dentali F, Gianni M, Crowther MA, Ageno W (2006). "Natural history of cerebral vein thrombosis: a systematic review". Blood. 108 (4): 1129–34. doi:10.1182/blood-2005-12-4795. PMID 16609071.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  11. ^ a b McElveen, W Alvin. "Cerebral Venous Thrombosis". Retrieved 2008-04-22.
Retrieved from "https://en.wikipedia.org/w/index.php?title=Cerebral_venous_sinus_thrombosis&oldid=208082665"