Cancer research: Difference between revisions

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Cancer research is the intense scientific effort to understand the development of cancer and identify potential therapies. As the Cancer Genome Project put it in a 2004 review articleTemplate:Fn, "a central aim of cancer research has been to identify the mutated genes that are causally implicated in oncogenesis (cancer genes)".

Cancer research ranges from molecular bioscience to the performance of clinical trials to evaluate and compare applications of the various cancer treatment modalities such as surgery, radiation therapy, chemotherapy, and hormone therapy, and combined treatment modalities such as chemo-radiotherapy. From the mid-1990s, the emphasis in clinical cancer research shifted towards therapies derived from biotechnology research, such as immunotherapy and gene therapy.

Advances

2005

The gene Reprimo has been found to be shut down in several cancers by rarely in healthy cells. The gene is methylated, sometimes in pre-cancerous growths and may be an early cancer indicator. Template:Fn

Genes involved in Cancer

Genes that have been identified by at least two idenpent publication to be involved in cancer are: ABI1, ABL2, ACSL6, AF1Q, AF5Q31, AKT1, ARNT, ASPSCR1, ATF1, ATIC, BCL10, BFHD, BIRC3, BMPR1A, BTG1, CBFA2T1, CBFA2T3, CBFB, CCND1, CDC2, CDK4, CHIC2, CHN1, COPEB, COX6C, CTNNB1, CYLD, DDB2, DDIT3, DEK, EIF4A2, EPS15, ERCC2, ERCC3, ERCC5, ERG, ETV4, ETV6, EWSR1, EXT1, EXT2, FANCC, FANCG, FGFR1OP, FH, FIP1L1, FUS, GAS7, GATA1, GMPS, GOLGA5, GPC, GPHN, HIST1H4I, HRAS, HSPCA, IL21R, IRF4, KRAS2, LASP1, LCP1, LHFP, LMO2, LYL1, MADH4, MLF1, MLH1, MLLT3, MLLT6, MNAT1, MSF, MSH2, MSN, MUTYH, MYC, NCOA4, NF2, NPM1, NRAS, PAX8, PCBD, PDGFB, PIM1, PLK2, PNUTL1, POU2F1, PPARG, PRCC, PRKACB, PRKAR1A, PTEN, PTPN11, RABEP1, RAD51L1, RAP1GDS1, RARA, RB1, RET, RHOH, RPL22, SBDS, SDHB, SEPTIN6, SET, SH3GL1, SS18L1, SSX1, SSX2, SSX4, STAT3, TAF15, TCF12, TCL1A, TFE3, TFEB, TFG, TFPT, TFRC, TNFRSF6, TP53, TPM3, TPM4, TRIP11, VHL, WAS, WT1, ZNF198, ZNF278, ZNF384, ZNFN1A1 based on a study by M. R Straton and co-workers " A census of human cancer genes".

References

Template:Fnb Template:Journal reference issue PMID 14993899
Template:Fnb Template:Journal reference issue PMID 15700311

External links

This biology article is a stub. You can help Wikipedia by expanding it.

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 ===2005===
 * The gene ''[[Reprimo]]'' has been found to be shut down in several cancers by rarely in healthy cells.  The gene is [[Methylation#Biological_methylation|methylated]], sometimes in pre-cancerous growths and may be an early cancer indicator. {{fn|2}}
+==Genes involved in Cancer==
+'''Genes that have been identified by at least two idenpent publication to be involved in cancer are:''' [[ABI1 gene| ABI1]],
+[[ABL2 gene| ABL2]],
+[[ACSL6 gene| ACSL6]],
+[[AF1Q gene| AF1Q]],
+[[AF5Q31 gene| AF5Q31]],
+[[AKT1 gene| AKT1]],
+[[ARNT gene| ARNT]],
+[[ASPSCR1 gene| ASPSCR1]],
+[[ATF1 gene| ATF1]],
+[[ATIC gene| ATIC]],
+[[BCL10 gene| BCL10]],
+[[BFHD gene| BFHD]],
+[[BIRC3 gene| BIRC3]],
+[[BMPR1A gene| BMPR1A]],
+[[BTG1 gene| BTG1]],
+[[CBFA2T1 gene| CBFA2T1]],
+[[CBFA2T3 gene| CBFA2T3]],
+[[CBFB gene| CBFB]],
+[[CCND1 gene| CCND1]],
+[[CDC2 gene| CDC2]],
+[[CDK4 gene| CDK4]],
+[[CHIC2 gene| CHIC2]],
+[[CHN1 gene| CHN1]],
+[[COPEB gene| COPEB]],
+[[COX6C gene| COX6C]],
+[[CTNNB1 gene| CTNNB1]],
+[[CYLD gene| CYLD]],
+[[DDB2 gene| DDB2]],
+[[DDIT3 gene| DDIT3]],
+[[DEK gene| DEK]],
+[[EIF4A2 gene| EIF4A2]],
+[[EPS15 gene| EPS15]],
+[[ERCC2 gene| ERCC2]],
+[[ERCC3 gene| ERCC3]],
+[[ERCC5 gene| ERCC5]],
+[[ERG gene| ERG]],
+[[ETV4 gene| ETV4]],
+[[ETV6 gene| ETV6]],
+[[EWSR1 gene| EWSR1]],
+[[EXT1 gene| EXT1]],
+[[EXT2 gene| EXT2]],
+[[FANCC gene| FANCC]],
+[[FANCG gene| FANCG]],
+[[FGFR1OP gene| FGFR1OP]],
+[[FH gene| FH]],
+[[FIP1L1 gene| FIP1L1]],
+[[FUS gene| FUS]],
+[[GAS7 gene| GAS7]],
+[[GATA1 gene| GATA1]],
+[[GMPS gene| GMPS]],
+[[GOLGA5 gene| GOLGA5]],
+[[GPC gene| GPC]],
+[[GPHN gene| GPHN]],
+[[HIST1H4I gene| HIST1H4I]],
+[[HRAS gene| HRAS]],
+[[HSPCA gene| HSPCA]],
+[[IL21R gene| IL21R]],
+[[IRF4 gene| IRF4]],
+[[KRAS2 gene| KRAS2]],
+[[LASP1 gene| LASP1]],
+[[LCP1 gene| LCP1]],
+[[LHFP gene| LHFP]],
+[[LMO2 gene| LMO2]],
+[[LYL1 gene| LYL1]],
+[[MADH4 gene| MADH4]],
+[[MLF1 gene| MLF1]],
+[[MLH1 gene| MLH1]],
+[[MLLT3 gene| MLLT3]],
+[[MLLT6 gene| MLLT6]],
+[[MNAT1 gene| MNAT1]],
+[[MSF gene| MSF]],
+[[MSH2 gene| MSH2]],
+[[MSN gene| MSN]],
+[[MUTYH gene| MUTYH]],
+[[MYC gene| MYC]],
+[[NCOA4 gene| NCOA4]],
+[[NF2 gene| NF2]],
+[[NPM1 gene| NPM1]],
+[[NRAS gene| NRAS]],
+[[PAX8 gene| PAX8]],
+[[PCBD gene| PCBD]],
+[[PDGFB gene| PDGFB]],
+[[PIM1 gene| PIM1]],
+[[PLK2 gene| PLK2]],
+[[PNUTL1 gene| PNUTL1]],
+[[POU2F1 gene| POU2F1]],
+[[PPARG gene| PPARG]],
+[[PRCC gene| PRCC]],
+[[PRKACB gene| PRKACB]],
+[[PRKAR1A gene| PRKAR1A]],
+[[PTEN gene| PTEN]],
+[[PTPN11 gene| PTPN11]],
+[[RABEP1 gene| RABEP1]],
+[[RAD51L1 gene| RAD51L1]],
+[[RAP1GDS1 gene| RAP1GDS1]],
+[[RARA gene| RARA]],
+[[RB1 gene| RB1]],
+[[RET gene| RET]],
+[[RHOH gene| RHOH]],
+[[RPL22 gene| RPL22]],
+[[SBDS gene| SBDS]],
+[[SDHB gene| SDHB]],
+[[SEPTIN6 gene| SEPTIN6]],
+[[SET gene| SET]],
+[[SH3GL1 gene| SH3GL1]],
+[[SS18L1 gene| SS18L1]],
+[[SSX1 gene| SSX1]],
+[[SSX2 gene| SSX2]],
+[[SSX4 gene| SSX4]],
+[[STAT3 gene| STAT3]],
+[[TAF15 gene| TAF15]],
+[[TCF12 gene| TCF12]],
+[[TCL1A gene| TCL1A]],
+[[TFE3 gene| TFE3]],
+[[TFEB gene| TFEB]],
+[[TFG gene| TFG]],
+[[TFPT gene| TFPT]],
+[[TFRC gene| TFRC]],
+[[TNFRSF6 gene| TNFRSF6]],
+[[TP53 gene| TP53]],
+[[TPM3 gene| TPM3]],
+[[TPM4 gene| TPM4]],
+[[TRIP11 gene| TRIP11]],
+[[VHL gene| VHL]],
+[[WAS gene| WAS]],
+[[WT1 gene| WT1]],
+[[ZNF198 gene| ZNF198]],
+[[ZNF278 gene| ZNF278]],
+[[ZNF384 gene| ZNF384]],
+[[ZNFN1A1 gene| ZNFN1A1]] based on a study by M. R Straton and co-workers " A census of human cancer genes".
 ==See also==