User talk:Jfdwolff

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pyelonephritis article

Thanks for your helpful suggestions, Jfdwolff. I have done my best to improve the references section of the pyelonephritis article. I have added several MEDRS-compliant and current textbook sources, and a few review articles from peer-reviewed journals. I have also removed the unnecessary medical terminology source and done a bit of copyediting. There is still a lot of work to be done, but I think this is a pretty good start. Before I go any further, I would like to consult with you on the article's organization. MEDMOS suggests the following outline for disease-related articles:

• Classification
• Signs and symptoms
• Causes
• Pathophysiology
• Diagnosis
• Prevention
• Management
• Prognosis
• Epidemiology

This is not exactly how I would have chosen to organize the article, but I assume the suggested outline is the result of some sort of consensus. Is there a good reason why we should deviate from the suggested guideline? DiverDave (talk) 19:37, 5 June 2011 (UTC)

I frequently deviate from the MEDMOS guideline when editorial judgement requires this. In my mind, you can't really discuss "classification" before you have discussed the parameters on the basis of which you might wish to classify a disease. JFW | T@lk 19:49, 5 June 2011 (UTC)

Wondering if you could verify the BNF ref?

Amoxicillin#Medical_uses Doc James (talk · contribs · email) 10:59, 6 June 2011 (UTC)

I have no access to issue 57, which is now 2 years old, but BNF 61 (section "Medical problems in dental practice", page 29) appears to completely rule out any antibiotic prophylaxis. This is based on National Institute for Health and Clinical Excellence. Clinical guideline 64: Prophylaxis against infective endocarditis. London, 2008.. A recent study in the BMJ (doi:10.1136/bmj.d2392) indicated that this restriction was not associated with worsening incidence of endocarditis. JFW | T@lk 11:08, 6 June 2011 (UTC)

Macula risk

Hi there Dr. Wolff, I thought I would ask you a question here (please feel free to delete it). I also am not fluent in wikipedia, nor do I have any interest in doing so. I am trying to post relevant information on a commercially available product (something that is quite frequent on wiki, see the entries for sildenafil, bevacizumab, etc...)

I spotted some recent input you gave on a page called Macula Risk (page I created by the way...) and have some questions to ask of you:

1) Original research- what does this mean? Is this improper? Please explain. I have addded more than 15 academic references

2) You indicate "No evidence that this has been properly validated"- would you like me to E-mail you the article outlining the validation of the technology, as published in IOVS (one of the most reputable journals in opthalmology) or just provide you the reference? Also, each of the individual markers in the composite assay has also been validated in at least 2 seperate, non-company sponsored studies, which in total have included more than 30,000 test subjects. I can send you all the references you need.

3) "no WP:MEDRS-compatible sources supporting DNA-based screening for AMDm."

The input given by wiki is:

Ideal sources for such content includes general or systematic reviews published in reputable medical journals, academic and professional books written by experts in a field and from a respected publisher, and medical guidelines or position statements from nationally or internationally recognised expert bodies.

This guideline supports the general sourcing policy at Wikipedia:Verifiability with specific attention given to sources appropriate for the medical and health-related content in any type of article, including alternative medicine. Sources for all other types of content—including that in medical articles—are covered by the general guideline on identifying reliable sources rather than this specific guideline.

I can provide you with copies of the following articles 1) Seddon et al "Prediction Model for Prevalence and Incidence of Advanced Age-Related Macular Degeneration Based on Genetic, Demographic, and Environmental Variables", IOVS May 2009 2) Zanke et al "a genetic approach to stratification of risk for AMD' Can J Opthamology 45 (1) 2010 22-27

Both of these outline the technology in the assay and its applicability

If you have any further questions regarding the academic pedigree of the genes in the Macula Risk assay, i would be more than happy to send you all the pdf's you need

Regards,

Gerry (Geert) Belgraver Dutch Guy canuck (talk) 13:47, 6 June 2011 (UTC)

I will respond on your talkpage. JFW | T@lk 14:30, 6 June 2011 (UTC)

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Thanks for hail

You called out to me at my IP address. See next for my identity. — Preceding unsigned comment added by 98.193.8.74 (talk) 22:35, 8 June 2011 (UTC)

Thanks for hail, pt 2.

This is me. Thanks for calling out. A Prof with little time for this, but want to actively encourage other well-trained individuals who are contributing. If yo recall what it was that I editted anonymously, gladly engage you in any necessary discussion. Prof D. Meduban (talk) 22:37, 8 June 2011 (UTC)

Proposed Image Deletion

A deletion discussion has just been created at Category talk:Unclassified Chemical Structures, which may involve one or more orphaned chemical structures, that has you user name in the upload history. Please feel free to add your comments.  Ronhjones  ^(Talk) 22:56, 10 June 2011 (UTC)

Pancreatic cancer

Dr Wolff

This is Professor Anirban Maitra from the Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins University. I see that you deleted some important external links related to pancreatic cancer, and especially those associated with Johns Hopkins University on Feb 2nd, 2011. Please note these links were not put for the purposes of self promotion, and certainly do not come under the category of "unnotable external links" of which you seem to be a self styled expert. The Johns Hopkins Pancreatic Cancer patient chat site was the first chat site dedicated to this disease, and on this very chat site was where the future founders of PanCAN, the largest patient advocacy organization for this disease in the USA, met. The existence of this chat site is an invaluable resource to patients, many of whom link to it from the Wikipedia page when they search for answers to their terrible disease. On this chat site, hundreds upon hundreds of patients and caregivers meet other afflicted individuals and get succor for their condition. Second, the link to the National Familial Pancreatic Tumor Registry (NFPTR) link which you also deleted happens to be the world's oldest and largest repository of familial pancreatic cancers, and has been one of the major sources for discovery of familial pancreatic cancer genes. There are over 3,000 families with pancreatic cancer who are part of this registry, and removing the link to this page is a gross disservice to other similar kindred that have multiple family members with the disease and are looking for answers. Finally, the main Goldman Cancer center webpage forms a portal through which patients with advanced disease often seek second or third opinions at our center, which has one of the largest pancreatic cancer populations in this country, if not worldwide. As a physician, you do great disservice to patients and family members who are looking for qualified answers from some of the foremost experts in this disease by clubbing these links under the connotation of "linkfarm" and deleting them. I would urge you to follow the historical contributions of Johns Hopkins and its pancreatic cancer clinical and research team to the understanding of pancreatic cancer, its biology, and its therapy before making empirical decisions of this nature. You are welcome to email me directly for clarifications, or to learn more about the contributions of Johns Hopkins and the role some of these websites have played in helping pancreatic cancer patients. I will revert these links back on the website in Wikipedia, and would greatly appreciate if you do not arbitrarily delete them. Thank you. Amaitra1 (talk) 02:15, 11 June 2011 (UTC)Amaitra1