Thyronamine

Thyronamine

Identifiers
CAS Number	500-78-7 Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL201896 Y
ChemSpider	2340781 Y
MeSH	thyronamine
PubChem CID	3083601
CompTox Dashboard (EPA)	DTXSID60198174
InChI InChI=1S/C14H15NO2/c15-10-9-11-1-5-13(6-2-11)17-14-7-3-12(16)4-8-14/h1-8,16H,9-10,15H2 Y Key: OVUVNKDANCKDCK-UHFFFAOYSA-N Y InChI=1/C14H15NO2/c15-10-9-11-1-5-13(6-2-11)17-14-7-3-12(16)4-8-14/h1-8,16H,9-10,15H2 Key: OVUVNKDANCKDCK-UHFFFAOYAP
SMILES O(c1ccc(cc1)CCN)c2ccc(O)cc2
Properties
Chemical formula	C14H15NO2
Molar mass	229.274 g mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Y verify (what is YN ?) Infobox references

Thyronamine refers both to a molecule, and to derivatives of that molecule: a family of decarboxylated and deiodinated metabolites of the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3).

Types

The group includes:

• Thyronamine (T0AM)
• 3-Iodothyronamine (T1AM), which is the most notable one as it is a trace amine found in the nervous system. It is a possible candidate for the natural ligand of the trace amine-associated receptor TAAR1 (TAR1), a G protein-coupled receptor located in the cell membrane (Piehl S, Hoefig CS, Scanlan TS, Köhrle J. (2011) Thyronamines - Past, Present, and Future. Endocrine Reviews 32:64-80).
• 3,5-Diiodothyronamine (T2AM)
• 3,5,3'-Triiodothyronamine (T3AM)

See also

• Trace amines
• Thyroid hormone