Talk:Equianalgesic: Difference between revisions
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== Oxymorphone vs. morphine == |
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If oral oxymorphone is 7 times stronger than oral morphine, how can 3.33 mg of oxymorphone be equivalent to 10 mg of morphine? I think an error has been made.[[Special:Contributions/66.249.82.173|66.249.82.173]] ([[User talk:66.249.82.173|talk]]) 11:42, 4 December 2014 (UTC) |
Revision as of 11:42, 4 December 2014
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The contents of the Opioid comparison page were merged into Equianalgesic on May 20, 2013. For the contribution history and old versions of the redirected page, please see its history; for the discussion at that location, see its talk page. |
Oral vs intramuscular morphine
I cannot find reliable Equianalgesic tables that use 10mg oral morphine as the base. They seem to mostly use 10mg IM morphine. Should we switch to that base to accurately source this page? It looks like this chart was straight copied from http://www.pharmer.org/forum/discussion-prescription-and-otc-meds/opioid-comparisonThe Irish Intinian (talk) 01:27, 22 December 2011 (UTC)
- The chart is in desperate need of some reliable sources. If more sources can be found for the 10 mg IM morphine base, I'd support it. The table should really be rebuilt from scratch in that case and each compound, or parameter of the compound, referenced to some article/table. – Acdx (talk) 03:41, 14 January 2012 (UTC)
- The values definitely need to be verified from top to bottom. Ideally, the chart should cover intravenous, oral, subcutaneous, sublingual, and transdermal routes, with the most common reference as a default baseline. — C M B J 11:15, 20 May 2013 (UTC)
- It shouldn't be too difficult to do that, since the charts are all over the web. Here's one. ISBN 9781585282975 appears to be a book on the subject; table 1-1 (p. 5) covers a lot of it. Table 42-1 (p. 523) in ISBN 9780849309267 covers routes of administration for more than a dozen drugs. WhatamIdoing (talk) 00:26, 4 February 2014 (UTC)
- The values definitely need to be verified from top to bottom. Ideally, the chart should cover intravenous, oral, subcutaneous, sublingual, and transdermal routes, with the most common reference as a default baseline. — C M B J 11:15, 20 May 2013 (UTC)
Acetaminophen IV vs Opiates
The reference only shows the reduction in pain score as rated by the patient after 60 minutes is comparable. I think this direct extrapolation of pain score to equivalent dose is original research, and dubious at that. For example this source http://www.drugs.com/pro/diflunisal.html compares 1000mg diflunisal to 600mg acetaminophen + 60mg codeine. This would put acetaminophen at 1/2400 the strength of oral morphine. Since this is a difference of 100 times, I will remove acetaminophen from the list until I find more conclusive sources. IrregularPoster (talk) 19:51, 25 September 2013 (UTC)
Morphine IV vs Morphine PO
Since Morphine IV is shown as 3 times stronger than Morphine PO, shouldn't the bio-availability of the morphine PO calculated as 33%?(assuming all other variants are held the same, such as cross tolerance and etc, which there was no indication to think otherwise on the chart.)
TY — Preceding unsigned comment added by 212.253.113.88 (talk) 09:00, 27 August 2014 (UTC)
Oxymorphone vs. morphine
If oral oxymorphone is 7 times stronger than oral morphine, how can 3.33 mg of oxymorphone be equivalent to 10 mg of morphine? I think an error has been made.66.249.82.173 (talk) 11:42, 4 December 2014 (UTC)