Xanthine oxidase inhibitor: Difference between revisions
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Xanthine oxidase inhibitors are of two kinds: [[purine analogue]]s and others. Purine analogues include [[allopurinol]], [[oxypurinol]],<ref name="pmid16135657">{{cite journal |author=Iwanaga T, Kobayashi D, Hirayama M, Maeda T, Tamai I |title=Involvement of uric acid transporter in increased renal clearance of the xanthine oxidase inhibitor oxypurinol induced by a uricosuric agent, benzbromarone |journal=Drug metabolism and disposition: the biological fate of chemicals |volume=33 |issue=12 |pages=1791–5 |date=December 2005 |pmid=16135657 |doi=10.1124/dmd.105.006056 |url=http://dmd.aspetjournals.org/cgi/pmidlookup?view=long&pmid=16135657 |
Xanthine oxidase inhibitors are of two kinds: [[purine analogue]]s and others. Purine analogues include [[allopurinol]], [[oxypurinol]],<ref name="pmid16135657">{{cite journal |author=Iwanaga T, Kobayashi D, Hirayama M, Maeda T, Tamai I |title=Involvement of uric acid transporter in increased renal clearance of the xanthine oxidase inhibitor oxypurinol induced by a uricosuric agent, benzbromarone |journal=Drug metabolism and disposition: the biological fate of chemicals |volume=33 |issue=12 |pages=1791–5 |date=December 2005 |pmid=16135657 |doi=10.1124/dmd.105.006056 |url=http://dmd.aspetjournals.org/cgi/pmidlookup?view=long&pmid=16135657 |
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}}</ref> and [[tisopurine]]. Others include [[febuxostat]],<ref name="pmid15751090">{{cite journal |author=Becker MA, Schumacher HR, Wortmann RL, ''et al.'' |title=Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase: a twenty-eight-day, multicenter, phase II, randomized, double-blind, placebo-controlled, dose-response clinical trial examining safety and efficacy in patients with gout |journal=Arthritis and rheumatism |volume=52 |issue=3 |pages=916–23 |date=March 2005 |pmid=15751090 |doi=10.1002/art.20935 |
}}</ref> and [[tisopurine]]. Others include [[febuxostat]],<ref name="pmid15751090">{{cite journal |author=Becker MA, Schumacher HR, Wortmann RL, ''et al.'' |title=Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase: a twenty-eight-day, multicenter, phase II, randomized, double-blind, placebo-controlled, dose-response clinical trial examining safety and efficacy in patients with gout |journal=Arthritis and rheumatism |volume=52 |issue=3 |pages=916–23 |date=March 2005 |pmid=15751090 |doi=10.1002/art.20935 |
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}}</ref> [[topiroxostat]], and [[inositol]]s ([[phytic acid]] and [[Inositol|myo-inositol]]). |
}}</ref> [[topiroxostat]], and [[inositol]]s ([[phytic acid]] and [[Inositol|myo-inositol]]{{Citation needed}}). |
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In experiments, numerous [[natural product]]s have been found to inhibit xanthine oxidase [[in vitro]] or in model animals ([[mouse|mice]], [[rat]]s). These include three [[flavonoid]]s that occur in many different fruits and vegetables: [[kaempferol]], [[myricetin]], and [[quercetin]].<ref name="pmid11673865">{{cite journal |
In experiments, numerous [[natural product]]s have been found to inhibit xanthine oxidase [[in vitro]] or in model animals ([[mouse|mice]], [[rat]]s). These include three [[flavonoid]]s that occur in many different fruits and vegetables: [[kaempferol]], [[myricetin]], and [[quercetin]].<ref name="pmid11673865">{{cite journal |
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Revision as of 20:56, 8 December 2014
A xanthine oxidase inhibitor is any substance that inhibits the activity of xanthine oxidase, an enzyme involved in purine metabolism. In humans, inhibition of xanthine oxidase reduces the production of uric acid, and several medications that inhibit xanthine oxidase are indicated for treatment of hyperuricemia and related medical conditions including gout.[1] Xanthine oxidase inhibitors are being investigated for management of reperfusion injury.
Xanthine oxidase inhibitors are of two kinds: purine analogues and others. Purine analogues include allopurinol, oxypurinol,[2] and tisopurine. Others include febuxostat,[3] topiroxostat, and inositols (phytic acid and myo-inositol[citation needed]).
In experiments, numerous natural products have been found to inhibit xanthine oxidase in vitro or in model animals (mice, rats). These include three flavonoids that occur in many different fruits and vegetables: kaempferol, myricetin, and quercetin.[4] More generally, planar flavones and flavonols with a 7-hydroxyl group inhibit xanthine oxidase.[5] An essential oil extracted from Cinnamomum osmophloeum inhibits xanthine oxidase in mice.[6] The natural product propolis from selected sources inhibits xanthine oxidase in rats; the specific substance responsible for this inhibition has not been identified, and the generality of these findings is unknown.[7] An extract of leaves of Pistacia integerrima also inhibits xanthine oxidase at a level that appears to merit further research.[8]
In folk medicine the tree fern Cyathea spinulosa (formerly Alsophila spinulosa) has been used for gout, but its most active component, caffeic acid, is only a weak inhibitor of xanthine oxidase.[9]
References
- ^ Pacher P, Nivorozhkin A, Szabó C (March 2006). "Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol". Pharmacol. Rev. 58 (1): 87–114. doi:10.1124/pr.58.1.6. PMC 2233605. PMID 16507884.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Iwanaga T, Kobayashi D, Hirayama M, Maeda T, Tamai I (December 2005). "Involvement of uric acid transporter in increased renal clearance of the xanthine oxidase inhibitor oxypurinol induced by a uricosuric agent, benzbromarone". Drug metabolism and disposition: the biological fate of chemicals. 33 (12): 1791–5. doi:10.1124/dmd.105.006056. PMID 16135657.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Becker MA, Schumacher HR, Wortmann RL; et al. (March 2005). "Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase: a twenty-eight-day, multicenter, phase II, randomized, double-blind, placebo-controlled, dose-response clinical trial examining safety and efficacy in patients with gout". Arthritis and rheumatism. 52 (3): 916–23. doi:10.1002/art.20935. PMID 15751090.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - ^ Selloum L, Reichl S, Müller M, Sebihi L, Arnhold J (November 2001). "Effects of flavonols on the generation of superoxide anion radicals by xanthine oxidase and stimulated neutrophils". Archives of Biochemistry and Biophysics. 395 (1): 49–56. doi:10.1006/abbi.2001.2562. PMID 11673865.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Nagao A, Seki M, Kobayashi H (October 1999). "Inhibition of xanthine oxidase by flavonoids". Bioscience, Biotechnology, and Biochemistry. 63 (10): 1787–90. doi:10.1271/bbb.63.1787. PMID 10671036.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Wang SY, Yang CW, Liao JW, Zhen WW, Chu FH, Chang ST (August 2008). "Essential oil from leaves of Cinnamomum osmophloeum acts as a xanthine oxidase inhibitor and reduces the serum uric acid levels in oxonate-induced mice". Phytomedicine. 15 (11): 940–5. doi:10.1016/j.phymed.2008.06.002. PMID 18693097.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Yoshizumi K, Nishioka N, Tsuji T (March 2005). "[Xanthine oxidase inhibitory activity and hypouricemia effect of propolis in rats]" ([dead link]). Yakugaku Zasshi (in Japanese). 125 (3): 315–21. doi:10.1248/yakushi.125.315. PMID 15738631.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Ahmad NS, Farman M, Najmi MH, Mian KB, Hasan A (May 2008). "Pharmacological basis for use of Pistacia integerrima leaves in hyperuricemia and gout". J Ethnopharmacol. 117 (3): 478–82. doi:10.1016/j.jep.2008.02.031. PMID 18420362.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Chiang HC, Lo YJ, Lu FJ (1994). "Xanthine oxidase inhibitors from the leaves of Alsophila spinulosa (Hook) Tryon". Journal of Enzyme Inhibition. 8 (1): 61–71. doi:10.3109/14756369409040777. PMID 7539070.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
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