COMT inhibitor

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A COMT inhibitor is a drug that inhibits the action of catechol-O-methyl transferase. This enzyme is involved in degrading neurotransmitters. COMT inhibitors are used in the treatment of Parkinson's disease.

Pharmaceutical examples include entacapone,[1] tolcapone,[2] and nitecapone.


  1. ^ Nissinen E; Nissinen H; Larjonmaa H; et al. (September 2005). "The COMT inhibitor, entacapone, reduces levodopa-induced elevations in plasma homocysteine in healthy adult rats". J Neural Transm 112 (9): 1213–1221. doi:10.1007/s00702-004-0262-4. PMID 15614425. 
  2. ^ Giakoumaki SG, Roussos P, Bitsios P (June 2008). "Improvement of Prepulse Inhibition and Executive Function by the COMT Inhibitor Tolcapone Depends on COMT Val158Met Polymorphism". Neuropsychopharmacology 33 (13): 3058–3068. doi:10.1038/npp.2008.82. PMID 18536698.