Cholecystokinin receptor

cholecystokinin A receptor
Identifiers
Symbol	CCKAR
NCBI gene	886
HGNC	1570
OMIM	118444
RefSeq	NM_000730
UniProt	P32238
Other data
Locus	Chr. 4 p15.2-p15.1
Search for Structures Swiss-model Domains InterPro

cholecystokinin B receptor
Identifiers
Symbol	CCKBR
NCBI gene	887
HGNC	1571
OMIM	118445
RefSeq	NM_176875
UniProt	P32239
Other data
Locus	Chr. 11 p15.4
Search for Structures Swiss-model Domains InterPro

Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors. There are two different subtypes CCK₁ and CCK₂. They are ~50% homologous. The CCK₁ receptor binds mostly to Cholecystokinin while CCK₂ also binds to gastrin. They are mostly involved in various digestive functions like gastrin-stimulated gastric acid secretion, gastric emptying and gut motility. In the brain, CCK functions as a neuropeptide and CCK receptors are involved in nociception, anxiety, memory and hunger.

External links

• IUPHAR GPCR Database - Cholecystokinin Receptors
• Cholecystokinin+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)