Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) and gastrin. There are two different subtypes CCKA and CCKB which are ~50% homologous: Various cholecystokinin antagonists have been developed and are used in research, although the only drug of this class that has been widely marketed to date is the anti-ulcer drug proglumide.
||primarily gastrointestinal tract, lesser amounts in the CNS
||sulfated CCK >> nonsulfated CCK ≈ nonsulfated CCK
||stimulation of bicarb secretion, gall bladder emptying and inhibiting gut motility
||primarily CNS, lesser amounts in the gastrointestinal tract
||gastrin ≈ CCK (receptor does not discriminate between sulfated and nonsulfated peptides)
||regulation of nociception, anxiety, memory and hunger
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