Jump to content

Myalgic encephalomyelitis/chronic fatigue syndrome: Difference between revisions

From Wikipedia, the free encyclopedia
Browse history interactively
← Previous editNext edit →
Content deleted Content added
VisualWikitext
Reverted 2 edits by 98.170.197.222 (talk): That's not what the source says. (TW)
Line 70: Line 70:


== Risk factors ==
== Risk factors ==
All ethnic groups and income levels are susceptible to the illness.<ref name="CDCRisk"/> The CDC states that ME/CFS is "at least as common" in African Americans and Hispanics as Caucasians. A 2009 meta-analysis, however, showed that compared with the White American majority, African Americans and Native Americans have a higher risk of CFS, though it acknowledged that studies and data were limited.<ref>{{cite journal | title = A systematic review of chronic fatigue, its syndromes and ethnicity: prevalence, severity, co-morbidity and coping | journal = International Journal of Epidemiology | volume = 38 | issue = 6 | pages = 1554–70 | year = 2009 | pmid = 19349479 | doi = 10.1093/ije/dyp147 | last1 = Dinos | first1 = S | last2 = Khoshaba | first2 = B | last3 = Ashby | first3 = D | last4 = White | first4 = PD | last5 = Nazroo |first5 = J | last6 = Wessely | first6 = S | last7 = Bhui | first7 = KS}}</ref> More women than men get CFS — between 60 and 85% of cases are women; however, there is some indication that the prevalence among men is underreported. The illness is reported to occur more frequently in people between the ages of 40 and 59.<ref name="PMID_15574853"/> CFS is less prevalent among children and adolescents than adults.<ref name="CDCBasic"/> Blood relatives of people who have CFS appear to be more predisposed.<ref name="CDCRisk"/><ref>{{cite journal | author = Walsh CM, Zainal NZ, Middleton SJ, Paykel ES | title = A family history study of chronic fatigue syndrome | journal = Psychiatr Genet | volume = 11 | issue = 3 | pages = 123–8 | year = 2001 | pmid = 11702053 | doi = 10.1097/00041444-200109000-00003 | last2 = Zainal | last3 = Middleton | last4 = Paykel }}</ref> There is no direct evidence that CFS is [[Contagious disease|contagious]].<ref>{{Cite web |url=http://www.cdc.gov/cfs/causes/risk-groups.html |title=Chronic Fatigue Syndrome—Who's at Risk? |publisher=Centers for Disease Control and Prevention|date=February 14, 2013|accessdate=2014-12-12}}</ref>
All ethnic groups and income levels are susceptible to the illness.<ref name="CDCRisk"/> The CDC states that ME/CFS is "at least as common" in African Americans and those of mixed race as Caucasians. A 2009 meta-analysis, however, showed that compared with the White American majority, African Americans and Native Americans have a higher risk of CFS, though it acknowledged that studies and data were limited.<ref>{{cite journal | title = A systematic review of chronic fatigue, its syndromes and ethnicity: prevalence, severity, co-morbidity and coping | journal = International Journal of Epidemiology | volume = 38 | issue = 6 | pages = 1554–70 | year = 2009 | pmid = 19349479 | doi = 10.1093/ije/dyp147 | last1 = Dinos | first1 = S | last2 = Khoshaba | first2 = B | last3 = Ashby | first3 = D | last4 = White | first4 = PD | last5 = Nazroo |first5 = J | last6 = Wessely | first6 = S | last7 = Bhui | first7 = KS}}</ref> More women than men get CFS — between 60 and 85% of cases are women; however, there is some indication that the prevalence among men is underreported. The illness is reported to occur more frequently in people between the ages of 40 and 59.<ref name="PMID_15574853"/> CFS is less prevalent among children and adolescents than adults.<ref name="CDCBasic"/> Blood relatives of people who have CFS appear to be more predisposed.<ref name="CDCRisk"/><ref>{{cite journal | author = Walsh CM, Zainal NZ, Middleton SJ, Paykel ES | title = A family history study of chronic fatigue syndrome | journal = Psychiatr Genet | volume = 11 | issue = 3 | pages = 123–8 | year = 2001 | pmid = 11702053 | doi = 10.1097/00041444-200109000-00003 | last2 = Zainal | last3 = Middleton | last4 = Paykel }}</ref> There is no direct evidence that CFS is [[Contagious disease|contagious]].<ref>{{Cite web |url=http://www.cdc.gov/cfs/causes/risk-groups.html |title=Chronic Fatigue Syndrome—Who's at Risk? |publisher=Centers for Disease Control and Prevention|date=February 14, 2013|accessdate=2014-12-12}}</ref>


A systematic review in 2008 included eleven primary studies that had assessed various demographic, medical, psychological, social and environmental factors to predict the development of CFS, and found many had reported significant associations to CFS.<ref name="PMID_17892624">{{cite journal | author = Hempel S, Chambers D, Bagnall AM, Forbes C | title = Risk factors for chronic fatigue syndrome/myalgic encephalomyelitis: a systematic scoping review of multiple predictor studies | journal = Psychol Med | volume = 38 | issue = 7 | pages = 915–26 | date = July 2008 | pmid = 17892624 | doi = 10.1017/S0033291707001602 | last2 = Chambers | last3 = Bagnall | last4 = Forbes }}</ref> The reviewers concluded that the lack of generalizability and replication between studies meant that "none of the identified factors appear suitable for the timely identification of patients at risk of developing CFS/ME within clinical practice."
A systematic review in 2008 included eleven primary studies that had assessed various demographic, medical, psychological, social and environmental factors to predict the development of CFS, and found many had reported significant associations to CFS.<ref name="PMID_17892624">{{cite journal | author = Hempel S, Chambers D, Bagnall AM, Forbes C | title = Risk factors for chronic fatigue syndrome/myalgic encephalomyelitis: a systematic scoping review of multiple predictor studies | journal = Psychol Med | volume = 38 | issue = 7 | pages = 915–26 | date = July 2008 | pmid = 17892624 | doi = 10.1017/S0033291707001602 | last2 = Chambers | last3 = Bagnall | last4 = Forbes }}</ref> The reviewers concluded that the lack of generalizability and replication between studies meant that "none of the identified factors appear suitable for the timely identification of patients at risk of developing CFS/ME within clinical practice."

Revision as of 17:52, 26 August 2015

This article is about the medical condition. For the symptom chronic fatigue, see Fatigue (medical).
Myalgic encephalomyelitis/chronic fatigue syndrome
SpecialtyNeurology, rheumatology Edit this on Wikidata

Chronic fatigue syndrome (CFS) is a complex medical condition, characterized by long-term fatigue and other symptoms.[1][2] These symptoms are to such a degree that they limit a person's ability to carry out ordinary daily activities.[2] The fatigue is not due to ongoing exertion, not relieved much by rest, and is not caused by other medical conditions.[3] CFS may also be referred to as systemic exertion intolerance disease (SEID), myalgic encephalomyelitis (ME), post-viral fatigue syndrome (PVFS), chronic fatigue immune dysfunction syndrome (CFIDS), or several other terms.[4] Biological, genetic, infectious, and psychological mechanisms have been proposed, but the cause is not understood.[5][6]

Symptoms of CFS include malaise after exertion; unrefreshing sleep, widespread muscle and joint pain, sore throat, headaches of a type not previously experienced, cognitive difficulties, chronic and severe mental and physical exhaustion. Additional symptoms may be reported, including muscle weakness, increased sensitivity to light, sounds and smells, problems standing upright, digestive disturbances, depression, painful and often slightly swollen lymph nodes, cardiac and respiratory problems.[7] It is unclear if these symptoms represent other associated conditions or if they are produced by CFS itself.[5] Symptoms vary in number, type, and severity from person to person.[8] Quality of life of persons with CFS can be extremely compromised.[9]

Fatigue is a common symptom in many illnesses, but the fatigue experienced by persons with CFS is comparatively rare.[10] Estimates of the number of people with the condition vary from 7 to 3,000 per 100,000 adults.[5][10] About one million Americans and a quarter of a million people in the UK have CFS.[11][12] CFS occurs more often in women than men,[13][14] and is less common among children and adolescents.[14]

There is agreement that CFS has a negative effect on health, happiness and productivity. However, various physicians' groups, researchers and patient advocates promote differing terminology, diagnostic criteria, proposed causes and treatments, resulting in controversy about many aspects of the disorder. The name "chronic fatigue syndrome" is controversial; many patients and advocacy groups, as well as some experts, believe the name trivializes the medical condition and they promote a name change.[15]

Signs and symptoms

Onset

The majority of CFS cases start suddenly,[16] usually accompanied by a "flu-like illness"[5] while a significant proportion of cases begin within several months of severe adverse stress.[16][17][18] An Australian prospective study found that after infection by viral and non-viral pathogens, a subset of individuals met the criteria for CFS, with the researchers concluding that "post-infective fatigue syndrome is a valid illness model for investigating one pathophysiological pathway to CFS".[19] However, accurate prevalence and exact roles of infection and stress in the development of CFS are currently unknown.

Symptoms

The most commonly used diagnostic criteria and definition of CFS for research and clinical purposes were published by the United States Centers for Disease Control and Prevention (CDC).[5] The CDC recommends the following three criteria be fulfilled:[20]

  1. A new onset (not lifelong) of severe fatigue for six consecutive months or greater duration which is unrelated to exertion, is not substantially relieved by rest, and is not a result of other medical conditions.
  2. The fatigue causes a significant reduction of previous activity levels.
  3. Four or more of the following symptoms that concurrently last six months or longer:
    • impaired memory or concentration
    • post-exertional malaise, where physical or mental exertions bring on "extreme, prolonged exhaustion and sickness"
    • unrefreshing sleep
    • muscle pain (myalgia)
    • pain in multiple joints (arthralgia)
    • headaches of a new kind or greater severity
    • sore throat, frequent or recurring
    • tender lymph nodes (cervical or axillary)

The CDC states other common symptoms include the following:[8]

The CDC proposes that persons with symptoms resembling those of CFS consult a physician to rule out several treatable illnesses: Lyme disease,[20] "sleep disorders, major depressive disorder, alcohol/substance abuse, diabetes, hypothyroidism, mononucleosis (mono), lupus, multiple sclerosis (MS), chronic hepatitis and various malignancies."[21] Medications can also cause side effects that mimic symptoms of CFS.[20]

Unlike the CDC's diagnostic criteria for CFS, the International Consensus Criteria for ME do not require the 6-month waiting period before diagnosis, noting that "No other disease criteria require that diagnoses be withheld until after the patient has suffered with the affliction for 6 months."[22]

Functioning

Despite a common diagnosis the functional capacity of individuals with CFS varies greatly.[23] Some persons with CFS lead relatively normal lives; others are totally bed-ridden and unable to care for themselves.[24] For the majority of persons with CFS, work, school, and family activities are significantly reduced for extended periods of time.[8] The severity of symptoms and disability is the same in both genders,[25] and many experience strongly disabling chronic pain.[26] Persons report critical reductions in levels of physical activity.[27] Also, a reduction in the complexity of activity has been observed.[28] Reported impairment is comparable to other fatiguing medical conditions[29] including late-stage AIDS,[30] lupus, rheumatoid arthritis, chronic obstructive pulmonary disease (COPD), and end-stage renal disease.[8] CFS affects a person's functional status and well-being more than major medical conditions such as multiple sclerosis, congestive heart failure, or type II diabetes mellitus.[9][31]

Often, there are courses of remission and relapse of symptoms which make the illness difficult to manage. Persons who feel better for a period may overextend their activities, and the result can be a worsening of their symptoms with a relapse of the illness.[8]

Employment rates vary with over half unable to work and nearly two-thirds limited in their work because of their illness. More than half were on disability benefits or temporary sick leave, and less than a fifth worked full-time.[24]

Cognitive functioning

Cognitive symptoms are mainly from deficits in attention, memory, and reaction time. The deficits are in the range of 0.5 to 1.0 standard deviations below expected and are likely to affect day-to-day activities. Simple and complex information processing speed and functions entailing working memory over long time periods were moderately to extensively impaired. These deficits are generally consistent with those reported by patients. Perceptual abilities, motor speed, language, reasoning, and intelligence did not appear to be significantly altered.[32]

Comorbidity

Many CFS patients will also have, or appear to have, other medical problems or related diagnoses. Fibromyalgia occurs in a large percentage of CFS patients between onset and the second year, and some researchers suggest fibromyalgia and CFS are related.[33] As previously mentioned, many CFS sufferers also experience symptoms of irritable bowel syndrome, temporomandibular joint pain, headache including migraines, and other forms of myalgia. CFS patients have significantly higher rates of current mood disorders than the general population.[34] Compared with the non-fatigued population, male CFS patients are more likely to experience chronic pelvic pain syndrome (CP/CPPS), and female CFS patients are also more likely to experience chronic pelvic pain.[35] CFS is significantly more common in women with endometriosis compared with women in the general USA population.[36]

Risk factors

All ethnic groups and income levels are susceptible to the illness.[14] The CDC states that ME/CFS is "at least as common" in African Americans and those of mixed race as Caucasians. A 2009 meta-analysis, however, showed that compared with the White American majority, African Americans and Native Americans have a higher risk of CFS, though it acknowledged that studies and data were limited.[37] More women than men get CFS — between 60 and 85% of cases are women; however, there is some indication that the prevalence among men is underreported. The illness is reported to occur more frequently in people between the ages of 40 and 59.[13] CFS is less prevalent among children and adolescents than adults.[11] Blood relatives of people who have CFS appear to be more predisposed.[14][38] There is no direct evidence that CFS is contagious.[39]

A systematic review in 2008 included eleven primary studies that had assessed various demographic, medical, psychological, social and environmental factors to predict the development of CFS, and found many had reported significant associations to CFS.[40] The reviewers concluded that the lack of generalizability and replication between studies meant that "none of the identified factors appear suitable for the timely identification of patients at risk of developing CFS/ME within clinical practice."

Pathophysiology

Main article: Pathophysiology of chronic fatigue syndrome

The causes and mechanisms of chronic fatigue syndrome are currently unknown, despite extensive research.[11] Research studies have developed and explored etiological hypotheses regarding a variety of factors, including oxidative stress, genetic predisposition,[41] infection by viruses and pathogenic bacteria, hypothalamic-pituitary-adrenal axis abnormalities, immune dysfunction as well as psychological and psychosocial factors. Although it is unclear whether such factors are causes or consequences of CFS (or both), various models have been proposed.[42][43][44]

A substantial body of evidence points to the following abnormalities in the hypothalamic-pituitary-adrenal axis (HPA axis) in CFS patients: mild hypocortisolism, an attenuated diurnal variation in cortisol, enhanced cortisol negative feedback, and a blunted HPA axis responsiveness. It is unclear whether or not these disturbances play a primary role in the pathogenesis of CFS.[45]

Persons diagnosed with the illness appear to have an abnormal immune response to exercise. Specifically, complement products are increased, larger oxidative stress is generated along with reduced anti-oxidant immune response, and larger interleukin-10 and toll-like receptor 4 gene expression are seen verses healthy controls. Many of these immune responses correlate with the symptom of post-exertional malaise.[46]

Diagnosis

There are no characteristic laboratory abnormalities to diagnose CFS,[47] so testing is used to rule out other potential causes for symptoms.[48] When symptoms are attributable to certain other conditions, the diagnosis of CFS is excluded. Important conditions and disorders to exclude are current/active major depression, schizophrenia, eating disorders such as anorexia nervosa and bulimia, bipolar disorder, alcohol abuse or other substance abuse. Current morbid obesity and active medical diseases need to be resolved and excluded before a diagnosis of chronic fatigue syndrome can be made.[49]

Definitions

Main article: Clinical descriptions of chronic fatigue syndrome

Notable definitions include:[7]

  • Centers for Disease Control and Prevention (CDC) definition (1994),[48] the most widely used clinical and research description of CFS,[5] is also called the Fukuda definition and is a revision of the Holmes or CDC 1988 scoring system.[50] The 1994 criteria require the presence of four or more symptoms beyond fatigue, while the 1988 criteria require six to eight.[2]
  • The ME/CFS 2003 Canadian Clinical working definition[51] states: "A patient with ME/CFS will meet the criteria for fatigue, post-exertional malaise and/or fatigue, sleep dysfunction, and pain; have two or more neurological/cognitive manifestations and one or more symptoms from two of the categories of autonomic, neuroendocrine, and immune manifestations; and the illness persists for at least 6 months".

Clinical practice guidelines are generally based on case descriptions with the aim of improving diagnosis, management, and treatment. An example is the CFS/ME guideline for the National Health Service in England and Wales, produced in 2007 by the National Institute for Health and Clinical Excellence (NICE).[2]

Differential diagnoses

Certain medical conditions can cause chronic fatigue and must be ruled out before a diagnosis of CFS can be given. Hypothyroidism, anemia, diabetes and certain psychiatric disorders are a few of the diseases that must be ruled out if the patient presents with appropriate symptoms.[2][48][52]

People with fibromyalgia (FM, or fibromyalgia syndrome, FMS), like those with CFS, have muscle pain, severe fatigue and sleep disturbances. The presence of allodynia (abnormal pain responses to mild stimulation) and of extensive tender points in specific locations differentiates FM from CFS, though the two diseases often co-occur.[53] Fatigue and muscle pain occurs frequently in the initial phase of various hereditary muscle disorders and in several autoimmune, endocrine and metabolic syndromes; and are frequently labelled as CFS or fibromyalgia in the absence of obvious biochemical/metabolic abnormalities and neurological symptoms.[citation needed]

A 2006 review found that there was a lack of literature to establish the discriminant validity of undifferentiated somatoform disorder from CFS. The author stated that there is a need for proponents of chronic fatigue syndrome to distinguish it from undifferentiated somatoform disorder. The author also mentioned that the experience of fatigue as exclusively physical and not mental is captured by the definition of somatoform disorder but not CFS.[54] Hysterical diagnoses are not merely diagnoses of exclusion but require criteria to be met on the positive grounds of both primary and secondary gain.[55]

Multiple chemical sensitivity, Gulf War syndrome and post-polio syndrome have symptoms similar to those of CFS,[56][57] and the last is also theorized to have a common pathophysiology.[57]

Depressive symptoms, if seen in CFS, may be differentially diagnosed from primary depression due to the absence of anhedonia, decreased motivation, and guilt; and the presence of somatic symptoms such as sore throat, swollen lymph nodes, and exercise intolerance with postexertional exacerbation of symptoms.[52]

Management

Main article: Chronic fatigue syndrome treatment

Many people do not fully recover from CFS even with treatment.[58] Cognitive behavioural therapy (CBT) and graded exercise therapy (GET) have shown moderate effectiveness in a number of randomized controlled trials.[59][60][61][62] As many of the CBT and GET studies required visits to a clinic, those severely affected may not have been included.[60] Two large surveys of patients indicated that pacing is a helpful intervention, or is considered useful by 82-96% of participants.[63][64] A comprehensive rehabilitation programme only rarely results in full recovery.[65] Medication plays a minor role in management.[66] No intervention has been proven effective in restoring the ability to work.[60]

Cognitive behavioral therapy

Cognitive behavioral therapy is a moderately effective psychological therapy[59][60] when used to treat CFS. It is often used alone or with other therapies to "manage activity levels, stress, and symptoms."[67] CBT tries to help patients understand their individual symptoms and beliefs and develop strategies to improve day-to-day functioning. CBT is thought to help patients by eliminating unhelpful illness beliefs which may perpetuate the illness.[68]

A Cochrane Review meta-analysis of 15 randomized, controlled cognitive behavioral therapy trials with 1043 participants concluded that CBT reduced the symptom of fatigue. Four studies showed that CBT resulted in a clinical response for 40% of participants vs 26% treated with "usual care". Similarly, in 3 studies CBT worked better than other types of psychological therapies (48% vs 27%). The effects of CBT may diminish after therapy is completed; the reviewers write that "the evidence base at follow-up is limited to a small group of studies with inconsistent findings" and encourage further studies.[69] A 2007 meta-analysis of 5 CBT randomized controlled trials of chronic fatigue and chronic fatigue syndrome reported 33-73% of the patients improved to the point of no longer being clinically fatigued.[70]

A 2010 meta-analysis of trials that measured physical activity before and after CBT reported that although CBT effectively reduced fatigue, activity levels were not affected by CBT and changes in physical activity were not related to changes in fatigue. They conclude that the effect of CBT on fatigue is not influenced by a change in physical activity.[71] According to a 2014 systematic review on recovery, the lack of changes to objectively measured physical activity after intervention is contrary to the cognitive behavioural model of CFS and suggests that patients still avoided postexertional symptom exacerbations and adapted to the illness rather than recovered from it.[72]

CBT has been criticised by patients' organisations because multiple patient surveys of their members[73] have indicated that CBT can make people worse.[74] Some dispute the validity of the evidence base behind CBT as well as graded exercise therapy (below), and conclude that it would be unethical to use these treatments.[75]

Exercise

Graded exercise therapy is a form of physical therapy. A meta-analysis published in 2004 of five randomized trials found that patients who received exercise therapy were less fatigued after 12 weeks than the control participants, and the authors cautiously conclude that GET shows promise as a treatment. However, after 6 months the benefit became non-significant compared to the control group who did not receive GET, and functional work capacity was not significantly improved after therapy.[76] A systematic review published in 2006 included the same five RCTs, noting that "no severely affected patients were included in the studies of GET".[60] A 2012 systematic review concluded that despite the consistent positive outcomes of exercise therapy studies for CFS, "exercise therapy is not a cure for CFS", and "a comprehensive rehabilitation programme only rarely results in full recovery".[65]

Surveys conducted on behalf of patient organizations find adverse effects to be very common.[74][77][78][79] To avoid detrimental effects from GET, care must be taken to avoid the exacerbation of symptoms while catering the program to individual capabilities and the fluctuating nature of symptoms.[80] A 2015 Cochrane review found that exercise therapy may reduce fatigue among people with CFS, and concluded that the effects of exercise therapy were comparable to those of cognitive-behavioral therapy.[81]

Pacing

Pacing is an energy management strategy based on the observation that symptoms of the illness tend to increase following minimal exertion. There are two forms: symptom-contingent pacing, where the decision to stop (and rest or change an activity) is determined by an awareness of an exacerbation of symptoms; and time-contingent pacing, which is determined by a set schedule of activities which a patient estimates he or she is able to complete without triggering post-exertional malaise (PEM).[82] Thus the principle behind pacing for CFS is to avoid over-exertion and an exacerbation of symptoms. It is not aimed at treating the illness as a whole. Those whose illness appears stable may gradually increase activity and exercise levels but according to the principle of pacing, must rest if it becomes clear that they have exceeded their limits. Some programmes combine symptom and time-contingent approaches. A trial of one such programme reported limited benefits.[80] A larger, randomised controlled trial found that pacing had statistically better results than relaxation/flexibility therapy.[83][84] A 2009 survey of 828 Norwegian CFS patients found that pacing was evaluated as useful by 96% of the participants.[78]

Other

Other treatments of CFS have been proposed but their effectiveness has not been confirmed.[85] Medications thought to have promise in alleviating symptoms include antidepressant and immunomodulatory agents.[86] The evidence for antidepressants is mixed,[87] and their use remains controversial.[88] Many CFS patients are sensitive to medications, particularly sedatives, and some patients report chemical and food sensitivities.[8] CFS patients have a low placebo response, especially to psychological-psychiatric interventions, perhaps due to patient expectations.[89]

Prognosis

A systematic review of 14 studies that described improvement and occupational outcomes of people with CFS found that "the median full recovery rate was 5% (range 0–31%) and the median proportion of patients who improved during follow-up was 39.5% (range 8–63%). Return to work at follow-up ranged from 8 to 30% in the three studies that considered this outcome." .... "In five studies, a worsening of symptoms during the period of follow-up was reported in between 5 and 20% of patients." A good outcome was associated with less fatigue severity at baseline. Other factors were occasionally, but not consistently, related to outcome, including age at onset (5 of 16 studies), and attributing illness to a psychological cause and/or having a sense of control over symptoms (4 of 16 studies).[90] Another review found that children have a better prognosis than adults, with 54–94% having recovered by follow-up compared to less than 10% of adults returning to pre-illness levels of functioning.[91]

A 2014 systematic review reported that estimates of recovery from CFS ranged between 0 to 66% in intervention studies and 2.6 to 62% in naturalistic studies. There was a lack of consensus in the literature on how recovery should be defined. "Recovery" was often based on limited assessments, less than a full restoration of health, and self-reports with a general lack of more objective measures, which when used, did not find significant changes in physical activity. The authors suggested that patients were still avoiding post-exertion symptom exacerbation, and could be clinically improving to a limited extent or adapting to ongoing illness rather than recovering. It was recommended using stricter and more comprehensive definitions of recovery which capture fatigue, function, patient perceptions, and recovery time following physical and mental exertion.[92]

Epidemiology

A 2003 review states that studies have reported between 7 and 3,000 cases of CFS for every 100,000 adults.[5] Ranjith reviewed the epidemiological literature on CFS and suggested that the wide variance of the prevalence estimates may be due to the different definitions of CFS in use, the settings in which patients were selected, and the methodology used to exclude study participants with possible alternative diagnoses.[10] The Centers for Disease Control reports that more than 1 million Americans have CFS and approximately 80% of the cases are undiagnosed.[11] Approximately 250,000 people in the UK are affected with the illness according to the National Health Service.[12]

History

Main article: History of chronic fatigue syndrome

In 1934, an outbreak then referred to as atypical poliomyelitis (at the time it was considered a form of polio) occurred at the Los Angeles County Hospital. It strongly resembled what Ramsay and Acheson would later describe as ME (in 1934, there were no follow-up data to indicate chronicity and it is not known how many of those affected remained ill). Of note are the neurological symptoms, the link with a polio outbreak and the fact that most of the patients were hospital staff.[93] During 1955, there were many similar outbreaks, the best known of which affected several hospitals that formed part of the Royal Free group in London. It also featured neurological signs and affected mostly the hospital staff.[94] CFS excludes these outbreaks by definition, though many patients have a post-viral onset and the literature relating to ME is considered relevant to the study of CFS. In 1969, benign myalgic encephalomyelitis was first classified into the International Classification of Diseases under Diseases of the nervous system.[95]

The name chronic fatigue syndrome was used in the medical literature in 1987[96] to describe a condition resembling "chronic active Epstein-Barr virus (EBV) infection" but which presented no evidence of active EBV as its cause. The initial case definition of CFS was published in 1988, "Chronic fatigue syndrome: a working case definition", (the Holmes definition), and displaced the name chronic Epstein-Barr virus syndrome. This research case definition was published after US Centers for Disease Control and Prevention epidemiologists examined the Lake Tahoe outbreak.[97][98][99] In 2006, the CDC commenced a national program to educate the American public and health care professionals about CFS.[100]

In 2009 the journal Science[101] published a study that identified the XMRV retrovirus in a population of people with CFS. Other studies failed to reproduce this finding,[102][103][104] and in 2011 the editor of Science formally retracted its XMRV paper[105] while the Proceedings of the National Academy of Sciences similarly retracted a 2010 paper which had appeared to support the finding of a connection between XMRV and CFS.[106]

Society and culture

Naming

Main article: Alternative names for chronic fatigue syndrome

Chronic fatigue syndrome is the most commonly used designation,[1] but widespread approval of a name is lacking.[73] Different authorities on the illness view CFS as a central nervous system, metabolic, infectious or post-infectious, cardiovascular, immune system or psychiatric disorder, and different symptom profiles may be caused by various disorders.[107]

Over time and in different countries, many names have been associated with the condition(s). Aside from CFS, some other names used include Akureyri disease, benign myalgic encephalomyelitis, chronic fatigue immune dysfunction syndrome, chronic infectious mononucleosis, epidemic myalgic encephalomyelitis, epidemic neuromyasthenia, Iceland disease, myalgic encephalomyelitis, myalgic encephalitis, myalgic encephalopathy, post-viral fatigue syndrome, raphe nucleus encephalopathy, Royal Free disease, Tapanui flu, and yuppie flu (the last considered pejorative).[108][109] Many patients would prefer a different name such as "myalgic encephalomyelitis", believing the name "chronic fatigue syndrome" trivializes the condition, prevents it from being seen as a serious health problem, and discourages research.[15][110][111]

A 2001 review referenced myalgic encephalomyelitis symptoms in a 1959 article by Acheson, stating ME could be a distinct syndrome from CFS. A 1999 review explained that the Royal Colleges of Physicians, Psychiatrists, and General Practitioners in 1996 advocated the use of chronic fatigue syndrome instead of myalgic encephalomyelitis or ME, which was in wide use in the United Kingdom, "because there is, so far, no recognized pathology in muscles and in the central nervous system as is implied by the term ME".[1][112] An editorial noted that the 1996 report received some acceptance, but also criticism from those advocating the use of different naming conventions, suggesting the report was biased, dominated by psychiatrists, and that dissenting voices were excluded.[113] In 2002, a Lancet commentary noted the recent report by the "Working Group on CFS/ME"[114] used the compromise name CFS/ME stating, "The fact that both names for the illness were used symbolises respect for different viewpoints whilst acknowledging the continuing lack of consensus on a universally acceptable name."[73]

A 2015 report from the Institute of Medicine proposes the illness be renamed "systemic exertion intolerance disease" and suggests new diagnostic criteria for it. Many patients, clinicians and researchers believe lengthy disproportionate exhaustion after physical or mental exertion is a core symptom (also known as post-exertional malaise).[4][115]

Economic impact

Reynolds et al. (2004)[116] estimated that the illness caused about $20,000 per person with CFS in lost productivity which totals to $9.1 billion per year in the United States.[107] This is comparable to other chronic illnesses that extract some of the biggest medical and socioeconomic costs.[49] A 2008 study[117] calculated that the total annual cost burden of ME/CFS to society in the US was extensive, and could approach $24.0 billion.[118]

Social issues

A study found that CFS patients report a heavy psychosocial burden.[119] A survey by the Tymes Trust reported that children with CFS often state that they struggle for recognition of their needs or they feel bullied by medical and educational professionals.[120]

Social support

Individuals with CFS may receive a poorer quality of social support than in those with other illnesses. One study found that CFS patients reported an increased incidence of negative/unsatisfying interactions with family, friends, colleagues and doctors, when compared with healthy controls and breast cancer patients currently in remission.[121]

Awareness day

May 12 is designated as International Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Awareness Day (ME/CFS). The day is observed so that stakeholders have an occasion to improve the knowledge of "the public, policymakers, and healthcare professionals about the symptoms, diagnosis, and treatment of ME/CFS, as well as the need for a better understanding of this complex illness."[122][123]

Doctor–patient relations

Some in the medical community do not recognize CFS as a real condition, nor is there agreement on its prevalence.[124][125][126] There has been much disagreement over proposed causes, diagnosis, and treatment of the illness.[127][128][129][130][131] This uncertainty can significantly affect doctor-patient relations. A 2006 survey of general medical practitioners in southwest England found that despite more than two thirds accepting CFS/ME as a recognizable clinical entity, nearly half did not feel confident with making the diagnosis and/or treating the disease. Three other key factors that were significantly, positively associated with GPs' attitudes were knowing someone socially with CFS/ME, being male and seeing more patients with the condition in the last year. [132]

From the patient perspective, one 1997 study found that 77% of individuals with ME/CFS reported negative experiences with health care providers.[133] In a more recent metanalysis of qualitative studies, a major theme identified in patient discourses was that they felt severely ill, yet blamed and dismissed.[134] Another recent study of themes in patient newsgroup postings noted key themes relating to denial of social recognition of suffering and feelings of being accused of "simply faking it". Another theme that emerged strongly was that achieving diagnosis and acknowledgement requires tremendous amounts of "hard work" by patients.[126][135]

Blood donation

Based on the possible link between CFS and XMRV, in 2010 a variety of national blood banks adopted measures to discourage or prohibit individuals diagnosed with CFS from donating blood. Organizations adopting these or similar measures included the Canadian Blood Services,[136] the New Zealand Blood Service,[137] the Australian Red Cross Blood Service[138] and the American Association of Blood Banks,[139] In November 2010, the UK National Blood Service introduced a permanent deferral of donation from ME/CFS patients based on the potential harm to those patients that may result from their giving blood.[140] Donation policy in the UK now states, "CFS is generally diagnosed by excluding other conditions and may follow an infection that may or may not have been viral and which may be carried by the affected individual."[140]

Controversy

Main article: Controversies related to chronic fatigue syndrome

There has been much contention over the etiology, pathophysiology,[40] nomenclature,[111] and diagnostic criteria of chronic fatigue syndrome.[127][128] Historically, many professionals within the medical community were unfamiliar with CFS, or did not recognize it as a real condition; nor was there agreement on its prevalence or seriousness.[125][126][141] Controversies still exist over funding for research and treatment of physiological versus psychological/psychosocial aspects of the illness.[142] Researchers who investigate CFS from a psychiatric perspective are often the target of critics who believe that CFS has a physical cause, and some researchers have been subject to verbal abuse, death threats and other harassment.[143][144]

Research

The different case definitions used to research the illness influence the types of patients selected for studies,[47] and research also suggests subtypes of patients may exist within a heterogeneous population.[107][145][146][147] In one of the definitions, symptoms are accepted that may suggest a psychiatric disorder while others specifically exclude primary psychiatric disorders.[7]

Funding

In November 2006, an unofficial inquiry by an ad hoc group of parliamentarians in the United Kingdom, set up and chaired by former MP, Dr Ian Gibson, called the Group on Scientific Research into ME,[148] was addressed by a government minister claiming that few good biomedical research proposals have been submitted to the Medical Research Council (MRC) in contrast to those for psychosocial research. They were also told by other scientists of proposals that have been rejected, with claims of bias against support for biomedical research.

The MRC confirmed to the Group that, from April 2003 to November 2006, it has turned down 10 biomedical applications relating to CFS/ME and funded five applications relating to CFS/ME, mostly in the psychiatric/psychosocial domain.

In 2008, the MRC set up an expert group to consider how the MRC might encourage new high-quality research into CFS/ME and partnerships between researchers already working on CFS/ME and those in associated areas. It currently lists CFS/ME with a highlight notice, inviting researchers to develop high-quality research proposals for funding.[149] In February 2010, the All-Party Parliamentary Group on ME (APPG on ME) produced a legacy paper, which welcomed the recent MRC initiative, but felt that there has been far too much emphasis in the past on psychological research with insufficient attention to biomedical research and that it is vital that further biomedical research be undertaken to help discover a cause and more effective forms of management for this disease.[150]

References

  1. ^ a b c Evengård B, Schacterle RS, Komaroff AL; Schacterle; Komaroff (Nov 1999). "Chronic fatigue syndrome: new insights and old ignorance". Journal of Internal Medicine. 246 (5): 455–469. doi:10.1046/j.1365-2796.1999.00513.x. PMID 10583715. Retrieved 2009-10-21.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ a b c d e Guideline 53: Chronic fatigue syndrome/myalgic encephalomyelitis (or encephalopathy). London: National Institute for Health and Clinical Excellence. 2007. ISBN 1-84629-453-3.
  3. ^ "Chronic Fatigue Syndrome: Case Definition". CDC. 2006-05-03. Retrieved 2009-01-22.
  4. ^ a b Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome; Board on the Health of Select Populations; Institute of, Medicine (10 February 2015). "Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness": 20. PMID 25695122. {{cite journal}}: Cite journal requires |journal= (help)
  5. ^ a b c d e f g Afari N, Buchwald D; Buchwald (2003). "Chronic fatigue syndrome: a review". Am J Psychiatr. 160 (2): 221–36. doi:10.1176/appi.ajp.160.2.221. PMID 12562565.
  6. ^ "Chronic Fatigue Syndrome Causes". Centers for Disease Control and Prevention. October 15, 2010. Retrieved 2012-12-20.
  7. ^ a b c Wyller VB (2007). "The chronic fatigue syndrome--an update". Acta neurologica Scandinavica. Supplementum. 187: 7–14. doi:10.1111/j.1600-0404.2007.00840.x. PMID 17419822.
  8. ^ a b c d e f "Chronic Fatigue Syndrome (CFS), Symptoms". Centers for Disease Control and Prevention. 2012-05-14. Retrieved 2012-09-23.
  9. ^ a b Anderson JS, Ferrans CE; Ferrans (June 1997). "The quality of life of persons with chronic fatigue syndrome". J Nerv Ment Dis. 185 (6): 359–67. doi:10.1097/00005053-199706000-00001. PMID 9205421.
  10. ^ a b c Ranjith G (2005). "Epidemiology of chronic fatigue syndrome". Occup Med (Lond). 55 (1): 13–29. doi:10.1093/occmed/kqi012. PMID 15699086.
  11. ^ a b c d "Chronic Fatigue Syndrome Basic Facts". Centers for Disease Control and Prevention. May 9, 2006. Retrieved 2008-02-07.
  12. ^ a b "Chronic fatigue syndrome". The National Health Service. 2009-06-29. Retrieved 2010-05-14.
  13. ^ a b Gallagher AM, Thomas JM, Hamilton WT, White PD; Thomas; Hamilton; White (2004). "Incidence of fatigue symptoms and diagnoses presenting in UK primary care from 1990 to 2001". J R Soc Med. 97 (12): 571–5. doi:10.1258/jrsm.97.12.571. PMC 1079668. PMID 15574853.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  14. ^ a b c d "Chronic Fatigue Syndrome Who's at risk?". Centers for Disease Control and Prevention. February 14, 2013. Retrieved 2013-09-25.
  15. ^ a b Ottati, Victor C. (2002). The social psychology of politics. New York: Kluwer Academic/Plenum. pp. 159–160. ISBN 0-306-46723-2. Retrieved 2009-08-11.
  16. ^ a b Salit IE (1997). "Precipitating factors for the chronic fatigue syndrome". J Psychiatr Res. 31 (1): 59–65. doi:10.1016/S0022-3956(96)00050-7. PMID 9201648.
  17. ^ Hatcher S, House A; House (2003). "Life events, difficulties and dilemmas in the onset of chronic fatigue syndrome: a case-control study" (PDF). Psychol Med. 33 (7): 1185–92. doi:10.1017/S0033291703008274. PMID 14580073.
  18. ^ Theorell T, Blomkvist V, Lindh G, Evengård B; Blomkvist; Lindh; Evengård (1999). "Critical life events, infections, and symptoms during the year preceding chronic fatigue syndrome (CFS): an examination of CFS patients and subjects with a nonspecific life crisis". Psychosom Med. 61 (3): 304–10. doi:10.1097/00006842-199905000-00009. PMID 10367610.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  19. ^ Hickie I, Davenport T, Wakefield D, Vollmer-Conna U, Cameron B, Vernon SD, Reeves WC, Lloyd A; Davenport; Wakefield; Vollmer-Conna; Cameron; Vernon; Reeves; Lloyd; Dubbo Infection Outcomes Study Group (2006). "Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study". BMJ. 333 (7568): 575. doi:10.1136/bmj.38933.585764.AE. PMC 1569956. PMID 16950834.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  20. ^ a b c "CDC - Chronic Fatigue Syndrome (CFS) - Diagnosis". Cdc.gov. Retrieved 2012-07-22.
  21. ^ articles with dead external links%5d%5d%5b%5bCategory:Articles with dead external links from April 2015%5d%5d[%5b%5bWikipedia:Link rot|dead link%5d%5d] "CDC, Chronic Fatigue Syndrome (CFS), Making a Diagnosis". Cdc.gov. Retrieved 2011-01-28. {{cite web}}: Check |url= value (help)
  22. ^ Carruthers, B. M.; Van De Sande, M. I.; De Meirleir, K. L.; Klimas, N. G.; Broderick, G.; Mitchell, T.; Staines, D.; Powles, A. C. P.; Speight, N.; Vallings, R.; Bateman, L.; Baumgarten-Austrheim, B.; Bell, D. S.; Carlo-Stella, N.; Chia, J.; Darragh, A.; Jo, D.; Lewis, D.; Light, A. R.; Marshall-Gradisbik, S.; Mena, I.; Mikovits, J. A.; Miwa, K.; Murovska, M.; Pall, M. L.; Stevens, S. (Aug 2011). "Myalgic encephalomyelitis: International Consensus Criteria". Journal of Internal Medicine. 270 (4): 327–338. doi:10.1111/j.1365-2796.2011.02428.x. PMC 3427890. PMID 21777306.
  23. ^ Vanness JM, Snell CR, Strayer DR, Dempsey L, Stevens SR; Snell; Strayer; Dempsey l; Stevens (2003). "Subclassifying chronic fatigue syndrome through exercise testing". Med Sci Sports Exerc. 35 (6): 908–13. doi:10.1249/01.MSS.0000069510.58763.E8. PMID 12783037.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  24. ^ a b Ross SD, Estok RP, Frame D, Stone LR, Ludensky V, Levine CB; Estok; Frame; Stone; Ludensky; Levine (2004). "Disability and chronic fatigue syndrome: a focus on function". Arch Intern Med. 164 (10): 1098–107. doi:10.1001/archinte.164.10.1098. PMID 15159267.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  25. ^ Ho-Yen DO, McNamara I; McNamara (1991). "General practitioners' experience of the chronic fatigue syndrome". Br J Gen Pract. 41 (349): 324–6. PMC 1371754. PMID 1777276.
  26. ^ Meeus M, Nijs J, Meirleir KD; Nijs; Meirleir (2007). "Chronic musculoskeletal pain in patients with the chronic fatigue syndrome: A systematic review". Eur J Pain. 11 (4): 377–386. doi:10.1016/j.ejpain.2006.06.005. PMID 16843021.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  27. ^ McCully KK, Sisto SA, Natelson BH; Sisto; Natelson (1996). "Use of exercise for treatment of chronic fatigue syndrome". Sports Med. 21 (1): 35–48. doi:10.2165/00007256-199621010-00004. PMID 8771284.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  28. ^ Burton C, Knoop H, Popovic N, Sharpe M, Bleijenberg G; Knoop; Popovic; Sharpe; Bleijenberg (June 2009). "Reduced complexity of activity patterns in patients with Chronic Fatigue Syndrome: a case control study". Biopsychosoc Med. 3 (1): 7. doi:10.1186/1751-0759-3-7. PMC 2697171. PMID 19490619.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  29. ^ Solomon L, Nisenbaum R, Reyes M, Papanicolaou DA, Reeves WC; Nisenbaum; Reyes; Papanicolaou; Reeves (2003). "Functional status of persons with chronic fatigue syndrome in the Wichita, Kansas, population". Health Qual Life Outcomes. 1 (1): 48–58. doi:10.1186/1477-7525-1-48. PMC 239865. PMID 14577835.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  30. ^ Mark, Loveless, MD, congressional testimony of, May 12, 1995, as reported in Hillary Johnson. (1996). Osler's Web: Inside the Labyrinth of the Chronic Fatigue Syndrome Epidemic. Crown Publishers, New York. ISBN 0-517-70353-X. pp.364-365
  31. ^ Komaroff AL, Fagioli LR, Doolittle TH, Gandek B, Gleit MA, Guerriero RT, Kornish RJ, Ware NC, Ware JE, Bates DW; Fagioli; Doolittle; Gandek; Gleit; Guerriero; Kornish Rj; Ware; Ware Jr; Bates (September 1996). "Health status in patients with chronic fatigue syndrome and in general population and disease comparison groups". Am. J. Med. 101 (3): 281–90. doi:10.1016/S0002-9343(96)00174-X. PMID 8873490.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  32. ^ Cockshell SJ, Mathias JL; Mathias (January 2010). "Cognitive functioning in chronic fatigue syndrome: a meta-analysis". Psychol Med. 40 (8): 1–15. doi:10.1017/S0033291709992054. PMID 20047703.
  33. ^ Friedberg F, Jason LA; Jason (2001). "Chronic fatigue syndrome and fibromyalgia: clinical assessment and treatment". J Clin Psychol. 57 (4): 433–55. doi:10.1002/jclp.1040. PMID 11255201.
  34. ^ Prins J, Bleijenberg G, Rouweler EK, van der Meer J; Bleijenberg; Rouweler; Van Der Meer (2005). "Effect of psychiatric disorders on outcome of cognitive-behavioural therapy for chronic fatigue syndrome". Br J Psychiatry. 187 (2): 184–5. doi:10.1192/bjp.187.2.184. PMID 16055833.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  35. ^ Aaron LA, Herrell R, Ashton S, Belcourt M, Schmaling K, Goldberg J, Buchwald D; Herrell; Ashton; Belcourt; Schmaling; Goldberg; Buchwald (2001). "Comorbid Clinical Conditions in Chronic Fatigue: A Co-Twin Control Study". Journal of general internal medicine. 16 (1): 24–31. doi:10.1111/j.1525-1497.2001.03419.x. PMC 1495162. PMID 11251747.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  36. ^ Sinaii N, Cleary SD, Ballweg ML, Nieman LK, Stratton P; Cleary; Ballweg; Nieman; Stratton (2002). "High rates of autoimmune and endocrine disorders, fibromyalgia, chronic fatigue syndrome and atopic diseases among women with endometriosis: a survey analysis". Hum Reprod. 17 (10): 2715–24. doi:10.1093/humrep/17.10.2715. PMID 12351553.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  37. ^ Dinos, S; Khoshaba, B; Ashby, D; White, PD; Nazroo, J; Wessely, S; Bhui, KS (2009). "A systematic review of chronic fatigue, its syndromes and ethnicity: prevalence, severity, co-morbidity and coping". International Journal of Epidemiology. 38 (6): 1554–70. doi:10.1093/ije/dyp147. PMID 19349479.
  38. ^ Walsh CM, Zainal NZ, Middleton SJ, Paykel ES; Zainal; Middleton; Paykel (2001). "A family history study of chronic fatigue syndrome". Psychiatr Genet. 11 (3): 123–8. doi:10.1097/00041444-200109000-00003. PMID 11702053.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  39. ^ "Chronic Fatigue Syndrome—Who's at Risk?". Centers for Disease Control and Prevention. February 14, 2013. Retrieved 2014-12-12.
  40. ^ a b Hempel S, Chambers D, Bagnall AM, Forbes C; Chambers; Bagnall; Forbes (July 2008). "Risk factors for chronic fatigue syndrome/myalgic encephalomyelitis: a systematic scoping review of multiple predictor studies". Psychol Med. 38 (7): 915–26. doi:10.1017/S0033291707001602. PMID 17892624.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  41. ^ Sanders P, Korf J; Korf (2008). "Neuroaetiology of chronic fatigue syndrome: an overview". World Journal of Biological Psychiatry. 9 (3): 165–71. doi:10.1080/15622970701310971. PMID 17853290.
  42. ^ Patarca-Montero R, Antoni M, Fletcher MA, Klimas NG; Antoni; Fletcher; Klimas (2001). "Cytokine and other immunologic markers in chronic fatigue syndrome and their relation to neuropsychological factors". Appl Neuropsychol. 8 (1): 51–64. doi:10.1207/S15324826AN0801_7. PMID 11388124.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  43. ^ Kuratsune H (June 2007). "[Overview of chronic fatigue syndrome focusing on prevalence and diagnostic criteria]". Nippon Rinsho (in Japanese). 65 (6): 983–90. PMID 17561686.
  44. ^ Vercoulen JH, Swanink CM, Galama JM, Fennis JF, Jongen PJ, Hommes OR, van der Meer JW, Bleijenberg G; Swanink; Galama; Fennis; Jongen; Hommes; Van Der Meer; Bleijenberg (1998). "The persistence of fatigue in chronic fatigue syndrome and multiple sclerosis: development of a model". J Psychosom Res. 45 (6): 507–17. doi:10.1016/S0022-3999(98)00023-3. PMID 9859853.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  45. ^ Papadopoulos, Andrew S.; Cleare, Anthony J. (27 September 2011). "Hypothalamic–pituitary–adrenal axis dysfunction in chronic fatigue syndrome". Nature Reviews Endocrinology. 8 (1): 22–32. doi:10.1038/nrendo.2011.153. PMID 21946893.
  46. ^ "Altered immune response to exercise in patients with chronic fatigue syndrome/myalgic encephalomyelitis: a systematic literature review" (PDF). Exerc Immunol Rev. 20: 94–116. 2014. PMID 24974723. Retrieved 2015-06-19. {{cite journal}}: Cite uses deprecated parameter |authors= (help)
  47. ^ a b Reeves WC, Lloyd A, Vernon SD, Klimas N, Jason LA, Bleijenberg G, Evengard B, White PD, Nisenbaum R, Unger ER; Lloyd; Vernon; Klimas; Jason; Bleijenberg; Evengard; White; Nisenbaum; Unger; International Chronic Fatigue Syndrome Study Group (2003). "Identification of ambiguities in the 1994 chronic fatigue syndrome research case definition and recommendations for resolution". BMC Health Serv Res. 3 (1): 25. doi:10.1186/1472-6963-3-25. PMC 317472. PMID 14702202.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  48. ^ a b c Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A; Straus; Hickie; Sharpe; Dobbins; Komaroff (15 Dec 1994). "The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group". Ann Intern Med. 121 (12): 953–9. doi:10.1059/0003-4819-121-12-199412150-00009. PMID 7978722. {{cite journal}}: Unknown parameter |doi_brokendate= ignored (|doi-broken-date= suggested) (help)CS1 maint: multiple names: authors list (link)
  49. ^ a b Avellaneda Fernández A, Pérez Martín A, Izquierdo Martínez M, Arruti Bustillo M, Barbado Hernández FJ, de la Cruz Labrado J, Díaz-Delgado Peñas R, Gutiérrez Rivas E, Palacín Delgado C, Rivera Redondo J, Ramón Giménez JR; Pérez Martín; Izquierdo Martínez; Arruti Bustillo; Barbado Hernández; de la Cruz Labrado J; Díaz-Delgado Peñas; Gutiérrez Rivas; Palacín Delgado; Rivera Redondo; Ramón Giménez (2009). "Chronic fatigue syndrome: aetiology, diagnosis and treatment". BMC Psychiatry. 9 Suppl 1: S1. doi:10.1186/1471-244X-9-S1-S1. PMC 2766938. PMID 19857242.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  50. ^ Holmes GP, Kaplan JE, Gantz NM, Komaroff AL, Schonberger LB, Straus SE, Jones JF, Dubois RE, Cunningham-Rundles C, Pahwa S; Kaplan; Gantz; Komaroff; Schonberger; Straus; Jones; Dubois; Cunningham-Rundles; Pahwa (1988). "Chronic fatigue syndrome: a working case definition". Ann Intern Med. 108 (3): 387–9. doi:10.7326/0003-4819-108-3-387. PMID 2829679.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  51. ^ Carruthers BM, Jain AK, De Meirleir KL, Peterson DL, Klimas NG; et al. (2003). "Myalgic encephalomyalitis/chronic fatigue syndrome: Clinical working definition, diagnostic and treatment protocols" (PDF). Journal of Chronic Fatigue Syndrome. 11 (1): 7–97. doi:10.1300/J092v11n01_02. {{cite journal}}: Explicit use of et al. in: |author2= (help); Unknown parameter |displayauthors= ignored (|display-authors= suggested) (help)CS1 maint: multiple names: authors list (link)
  52. ^ a b Craig T, Kakumanu S; Kakumanu (Mar 2002). "Chronic fatigue syndrome: evaluation and treatment". Am Fam Physician. 65 (6): 1083–90. PMID 11925084.
  53. ^ Bradley LA, McKendree-Smith NL, Alarcón GS; McKendree-Smith; Alarcón (2000). "Pain complaints in patients with fibromyalgia versus chronic fatigue syndrome". Curr Rev Pain. 4 (2): 148–57. doi:10.1007/s11916-000-0050-2. PMID 10998728.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  54. ^ van Staden WC (2006). "Conceptual issues in undifferentiated somatoform disorder and chronic fatigue syndrome". Curr Opin Psychiatry. 19 (6): 613–8. doi:10.1097/01.yco.0000245753.83502.d9. PMID 17012941.
  55. ^ Jenkins R, Mowbray J, ed. Post-viral Fatigue Syndrome. 1991 John Wiley & Sons Ltd
  56. ^ Vojdani A, Thrasher JD; Thrasher (2004). "Cellular and humoral immune abnormalities in Gulf War veterans". Environ Health Perspect. 112 (8): 840–6. doi:10.1289/ehp.6881. PMC 1242010. PMID 15175170.
  57. ^ a b Bruno RL, Creange SJ, Frick NM; Creange; Frick (1998). "Parallels between post-polio fatigue and chronic fatigue syndrome: a common pathophysiology?". Am J Med. 105 (3A): 66S–73S. doi:10.1016/S0002-9343(98)00161-2. PMID 9790485.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  58. ^ Rimes KA, Chalder T; Chalder (2005). "Treatments for chronic fatigue syndrome". Occupational Medicine. 55 (1): 32–39. doi:10.1093/occmed/kqi015. PMID 15699088.
  59. ^ a b Whiting P, Bagnall AM, Sowden AJ, Cornell JE, Mulrow CD, Ramírez G; Bagnall; Sowden; Cornell; Mulrow; Ramírez (September 2001). "Interventions for the treatment and management of chronic fatigue syndrome: a systematic review". JAMA. 286 (11): 1360–8. doi:10.1001/jama.286.11.1360. PMID 11560542.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  60. ^ a b c d e Chambers D, Bagnall AM, Hempel S, Forbes C; Bagnall; Hempel; Forbes (2006). "Interventions for the treatment, management and rehabilitation of patients with chronic fatigue syndrome/myalgic encephalomyelitis: an updated systematic review". Journal of the Royal Society of Medicine. 99 (10): 506–20. doi:10.1258/jrsm.99.10.506. PMC 1592057. PMID 17021301.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  61. ^ Raine R, Haines A, Sensky T, Hutchings A, Larkin K, Black N; Haines; Sensky; Hutchings; Larkin; Black (2002). "Systematic review of mental health interventions for patients with common somatic symptoms: can research evidence from secondary care be extrapolated to primary care?". BMJ. 325 (7372): 1082. doi:10.1136/bmj.325.7372.1082. PMC 131187. PMID 12424170.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  62. ^ Reid S, Chalder T, Cleare A, Hotopf M, Wessely S; Chalder; Cleare; Hotopf; Wessely (2000). "Chronic fatigue syndrome". BMJ. 320 (7230): 292–6. doi:10.1136/bmj.320.7230.292. PMC 1117488. PMID 10650029.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  63. ^ "Survey Summary Report 2008" (PDF). Action for ME. 2008. p. 13. Retrieved 12 October 2013.
  64. ^ Bjørkum T, Wang CE, Waterloo K; Wang; Waterloo (June 2009). "Pasienterfaringer med ulike tiltak ved kronisk utmattelsessyndrom". Tidsskrift for Den norske legeforening (in Norwegian). 129 (12): 1214–6. doi:10.4045/tidsskr.09.35791. PMID 19521443. {{cite journal}}: Unknown parameter |trans_title= ignored (|trans-title= suggested) (help)CS1 maint: multiple names: authors list (link)
  65. ^ a b Van Cauwenbergh D, De Kooning M, Ickmans K, Nijs J; De Kooning; Ickmans; Nijs (2012). "How to exercise people with chronic fatigue syndrome: evidence-based practice guidelines". Eur J Clin Invest. 42 (10): 1136–4. doi:10.1111/j.1365-2362.2012.02701.x. PMID 22725992.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  66. ^ Van Houdenhove B, Pae CU, Luyten P; Pae; Luyten (February 2010). "Chronic fatigue syndrome: is there a role for non-antidepressant pharmacotherapy?". Expert opinion on pharmacotherapy. 11 (2): 215–23. doi:10.1517/14656560903487744. PMID 20088743.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  67. ^ "Improving Health and Quality of Life". Centers for Disease Control and Prevention. February 14, 2013. Retrieved 12 October 2013.
  68. ^ Wolfe F; Chalmers A; Littlejohn GO & Salit I (1995). Fibromyalgia, Chronic Fatigue Syndrome, and Repetitive Strain Injury: Current Concepts in Diagnosis, Management, Disability, and Health Economics. New York: Haworth Medical Press. p. 142. ISBN 1-56024-744-4.{{cite book}}: CS1 maint: multiple names: authors list (link)
  69. ^ Price JR, Mitchell E, Tidy E, Hunot V; Mitchell; Tidy; Hunot (2008). Price, Jonathan R (ed.). "Cognitive behaviour therapy for chronic fatigue syndrome in adults". Cochrane Database Syst Rev (3): CD001027. doi:10.1002/14651858.CD001027.pub2. PMID 18646067.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  70. ^ Malouff JM, Thorsteinsson EB, Rooke SE, Bhullar N, Schutte NS; Thorsteinsson; Rooke; Bhullar; Schutte (June 2008). "Efficacy of cognitive behavioral therapy for chronic fatigue syndrome: a meta-analysis". Clin Psychol Rev. 28 (5): 736–45. doi:10.1016/j.cpr.2007.10.004. PMID 18060672.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  71. ^ Wiborg JF, Knoop H, Stulemeijer M, Prins JB, Bleijenberg G; Knoop; Stulemeijer; Prins; Bleijenberg (January 2010). "How does cognitive behaviour therapy reduce fatigue in patients with chronic fatigue syndrome? The role of physical activity". Psychol Med. 40 (8): 1–7. doi:10.1017/S0033291709992212. PMID 20047707.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  72. ^ Adamowicz JL, Caikauskaite I, Friedberg F; Caikauskaite; Friedberg (Nov 2014). "Defining recovery in chronic fatigue syndrome: a critical review". Qual Life Res. 23 (9): 2407–16. doi:10.1007/s11136-014-0705-9. PMID 24791749.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  73. ^ a b c Clark C, Buchwald D, MacIntyre A, Sharpe M, Wessely S; Buchwald; MacIntyre; Sharpe; Wessely (January 2002). "Chronic fatigue syndrome: a step towards agreement". Lancet. 359 (9301): 97–8. doi:10.1016/S0140-6736(02)07336-1. PMID 11809249.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  74. ^ a b White PD, Sharpe MC, Chalder T, DeCesare JC, Walwyn R; Sharpe; Chalder; Decesare; Walwyn; Pace Trial (2007). "Protocol for the PACE trial: A randomised controlled trial of adaptive pacing, cognitive behaviour therapy, and graded exercise as supplements to standardised specialist medical care versus standardised specialist medical care alone for patients with the chronic fatigue syndrome/myalgic encephalomyelitis or encephalopathy". BMC Neurol. 7: 6. doi:10.1186/1471-2377-7-6. PMC 2147058. PMID 17397525.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  75. ^ Twisk FN, Maes M; Maes (2009). "A review on cognitive behavorial therapy (CBT) and graded exercise therapy (GET) in myalgic encephalomyelitis (ME) / chronic fatigue syndrome (CFS): CBT/GET is not only ineffective and not evidence-based, but also potentially harmful for many patients with ME/CFS". Neuro Endocrinol. Lett. 30 (3): 284–99. PMID 19855350.
  76. ^ Edmonds M, McGuire H, Price J; McGuire; Price (2004). Price, Jonathan R (ed.). "Exercise therapy for chronic fatigue syndrome". Cochrane Database Syst Rev (3): CD003200. doi:10.1002/14651858.CD003200.pub2. PMID 15266475.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  77. ^ Clark C, Buchwald D, MacIntyre A, Sharpe M, Wessely S; Buchwald; MacIntyre; Sharpe; Wessely (2002). "Chronic fatigue syndrome: a step towards agreement". Lancet. 359 (9301): 97–8. doi:10.1016/S0140-6736(02)07336-1. PMID 11809249.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  78. ^ a b Bjørkum T, Wang CE, Waterloo K; Wang; Waterloo (June 2009). "Patients' experience with treatment of chronic fatigue syndrome". Tidsskr nor Laegeforen. 129 (12): 1214–6. doi:10.4045/tidsskr.09.35791. PMID 19521443.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  79. ^ Working Party on CFS/ME (January 2002). "Report of the Working Party on CFS/ME to the Chief Medical Officer for England and Wales". Department of Health. Archived from the original on 2012-01-07.
  80. ^ a b Nijs J, Paul L, Wallman K; Paul; Wallman (April 2008). "Chronic fatigue syndrome: an approach combining self-management with graded exercise to avoid exacerbations". J Rehabil Med. 40 (4): 241–7. doi:10.2340/16501977-0185. PMID 18382818.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  81. ^ Larun, L; Brurberg, KG; Odgaard-Jensen, J; Price, JR (10 February 2015). "Exercise therapy for chronic fatigue syndrome". The Cochrane database of systematic reviews. 2: CD003200. doi:10.1002/14651858.CD003200.pub3. PMID 25674924.
  82. ^ Goudsmit EM, Nijs J, Jason LA, Wallman KE; Nijs; Jason; Wallman (19 December 2011). "Pacing as a strategy to improve energy management in myalgic encephalomyelitis/chronic fatigue syndrome: a consensus document". Disability and Rehabilitation. Early Online (13): 1–8. doi:10.3109/09638288.2011.635746. PMID 22181560.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  83. ^ Wallman KE, Morton AR, Goodman C, Grove R, Guilfoyle AM; Morton; Goodman; Grove; Guilfoyle (May 2004). "Randomised controlled trial of graded exercise in chronic fatigue syndrome". Med. J. Aust. 180 (9): 444–8. PMID 15115421.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  84. ^ Nijs J, Meeus M, De Meirleir K; Meeus; De Meirleir (August 2006). "Chronic musculoskeletal pain in chronic fatigue syndrome: recent developments and therapeutic implications". Man Ther. 11 (3): 187–91. doi:10.1016/j.math.2006.03.008. PMID 16781183.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  85. ^ Prins JB, van der Meer JW, Bleijenberg G; Van Der Meer; Bleijenberg (2006). "Chronic fatigue syndrome". Lancet. 367 (9507): 346–55. doi:10.1016/S0140-6736(06)68073-2. PMID 16443043.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  86. ^ Covelli V, Passeri ME, Leogrande D, Jirillo E, Amati L; Passeri; Leogrande; Jirillo; Amati (2005). "Drug targets in stress-related disorders". Curr. Med. Chem. 12 (15): 1801–9. doi:10.2174/0929867054367202. PMID 16029148.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  87. ^ Jackson JL, O'Malley PG, Kroenke K; O'Malley; Kroenke (January 30, 2006). "Antidepressants and cognitive-behavioral therapy for symptom syndromes". CNS Spectr. 11 (3): 212–22. PMID 16575378.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  88. ^ Pae CU, Marks DM, Patkar AA, Masand PS, Luyten P, Serretti A; Marks; Patkar; Masand; Luyten; Serretti (July 2009). "Pharmacological treatment of chronic fatigue syndrome: focusing on the role of antidepressants". Expert Opin Pharmacother. 10 (10): 1561–70. doi:10.1517/14656560902988510. PMID 19514866.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  89. ^ Cho HJ, Hotopf M, Wessely S; Hotopf; Wessely (2005). "The placebo response in the treatment of chronic fatigue syndrome: A systematic review and meta-analysis". Psychosom Med. 67 (2): 301–13. doi:10.1097/01.psy.0000156969.76986.e0. PMID 15784798. Retrieved 2008-12-12.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  90. ^ Cairns R, Hotopf M; Hotopf (2005). "A systematic review describing the prognosis of chronic fatigue syndrome". Occupational medicine (Oxford, England). 55 (1): 20–31. doi:10.1093/occmed/kqi013. PMID 15699087.
  91. ^ Joyce J, Hotopf M, Wessely S; Hotopf; Wessely (1997). "The prognosis of chronic fatigue and chronic fatigue syndrome: a systematic review". QJM. 90 (3): 223–33. doi:10.1093/qjmed/90.3.223. PMID 9093600.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  92. ^ "Defining recovery in chronic fatigue syndrome: a critical review". Quality of Life Research. 23: 2407–16. Nov 2014. doi:10.1007/s11136-014-0705-9. PMID 24791749.
  93. ^ Ramsay AM. Myalgic encephalomyelitis and postviral fatigue states. Second Ed. 1988
  94. ^ Acheson ED (1959). "The clinical syndrome variously called benign myalgic encephalomyelitis, Iceland disease and epidemic neuromyasthenia". The American Journal of Medicine. 26 (4): 569–95. doi:10.1016/0002-9343(59)90280-3. PMID 13637100.
  95. ^ International Classification of Diseases. Vol. I. World Health Organization. 1969. pp. 158, (vol 2, pp. 173).
  96. ^ Buchwald D, Sullivan JL, Komaroff AL; Sullivan; Komaroff (1987). "Frequency of 'chronic active Epstein-Barr virus infection' in a general medical practice". JAMA: the Journal of the American Medical Association. 257 (17): 2303–7. doi:10.1001/jama.257.17.2303. PMID 3033338.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  97. ^ Holmes GP, Kaplan JE, Gantz NM, Komaroff AL, Schonberger LB, Straus SE, Jones JF, Dubois RE, Cunningham-Rundles C, Pahwa S; Kaplan; Gantz; Komaroff; Schonberger; Straus; Jones; Dubois; Cunningham-Rundles; Pahwa (1988). "Chronic fatigue syndrome: A working case definition". Annals of internal medicine. 108 (3): 387–9. doi:10.7326/0003-4819-108-3-387. PMID 2829679.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  98. ^ Sharpe M & Campling F (2000). Chronic Fatigue Syndrome (CFS/ME): TheFacts. Oxford: Oxford Press. pp. 14, 15. ISBN 0-19-263049-0. Retrieved 2008-04-02.
  99. ^ Packard RM, Berkelman RL, Brown PJ, Frumkin H (2004). Emerging Illnesses and Society. JHU Press. p. 156. ISBN 0-8018-7942-6. Retrieved 2008-04-02.{{cite book}}: CS1 maint: multiple names: authors list (link)
  100. ^ "Press Briefing Transcripts". Centers for Disease Control and Prevention. November 3, 2006. Retrieved 2013-10-12.
  101. ^ Lombardi VC; Ruscetti FW; Das Gupta J; et al. (October 2009). "Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome". Science. 326 (5952): 585–9. Bibcode:2009Sci...326..585L. doi:10.1126/science.1179052. PMID 19815723. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help) (Retracted, see  [doi:10.1126/science.334.6063.1636-a])
  102. ^ Erlwein O; et al. (2010). Nixon, Douglas F (ed.). "Failure to detect the novel retrovirus XMRV in chronic fatigue syndrome". PLoS ONE. 5 (1): e8519. Bibcode:2010PLoSO...5.8519E. doi:10.1371/journal.pone.0008519. PMC 2795199. PMID 20066031.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  103. ^ Harriet C T Groom, Virginie C Boucherit, Kerry Makinson, Edward Randal, Sarah Baptista, Suzanne Hagan, John W Gow, Frank M Mattes, Judith Breuer, Jonathan R Kerr, Jonathan P Stoye, Kate N Bishop (2010). "Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome". Retrovirology. 7 (1): 10. doi:10.1186/1742-4690-7-10. PMC 2839973. PMID 20156349.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  104. ^ van Kuppeveld FJ; Jong AS; Lanke KH; et al. (2010). "Prevalence of xenotropic murine leukaemia virus-related virus in patients with chronic fatigue syndrome in the Netherlands: retrospective analysis of samples from an established cohort". BMJ. 340: c1018. doi:10.1136/bmj.c1018. PMC 2829122. PMID 20185493. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
  105. ^ Alberts B (December 2011). "Retraction". Science. 334 (6063): 1636. Bibcode:2011Sci...334.1636A. doi:10.1126/science.334.6063.1636-a. PMID 22194552.
  106. ^ Lo SC, Pripuzova N, Li B; et al. (January 2012). "Retraction for Lo et al., Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors". Proc. Natl. Acad. Sci. U.S.A. 109 (1): 346. Bibcode:2012PNAS..109..346.. doi:10.1073/pnas.1119641109. PMC 3252929. PMID 22203980. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  107. ^ a b c Jason LA, Corradi K, Torres-Harding S, Taylor RR, King C; Corradi; Torres-Harding; Taylor; King (March 2005). "Chronic fatigue syndrome: the need for subtypes". Neuropsychol Rev. 15 (1): 29–58. doi:10.1007/s11065-005-3588-2. PMID 15929497.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  108. ^ NORD (June 23, 2008). "Chronic Fatigue Syndrome/Myalgic Encephalomyelitis". National Organization for Rare Disorders, Inc. Retrieved 2008-07-01.
  109. ^ Donoghue, PJ; Siegel ME (1992). Sick And Tired Of Feeling Sick And Tired: Living with Invisible Chronic Illness. W. W. Norton & Company. p. 15. ISBN 0-393-03408-9. Retrieved 2008-09-17.
  110. ^ Sharpe M (2002). "The report of the Chief Medical Officer's CFS/ME working group: what does it say and will it help?". Clin Med. 2 (5): 427–9. doi:10.7861/clinmedicine.2-5-427. PMID 12448589.
  111. ^ a b Tuller, David (2008-05-30). "Chronic Fatigue Syndrome No Longer Seen as 'Yuppie Flu'". The New York Times. Retrieved 2015-06-29.
  112. ^ Royal Colleges of Physicians, Psychiatrists and General Practitioners (1996). Chronic fatigue syndrome; Report of a joint working group of the Royal Colleges of Physicians, Psychiatrists and General Practitioners. London, UK: Royal College of Physicians of London. ISBN 1-86016-046-8.
  113. ^ The Lancet (Oct 1996). "Frustrating survey of chronic fatigue". Lancet. 348 (9033): 971. doi:10.1016/S0140-6736(05)64917-3. PMID 8855845.
  114. ^ Working Party on CSF/ME (January 2002). "Report of the Working Party on CSF/ME to the Chief Medical Officer for England and Wales" (PDF). Department of Health. Archived from the original (PDF) on 2003-03-22. Retrieved 2009-01-25.
  115. ^ Chronic Fatigue Syndrome Gets a New Name By David Tuller February 10, 2015 11:01 am New York Times
  116. ^ Reynolds KJ, Vernon SD, Bouchery E, Reeves WC; Vernon; Bouchery; Reeves (2004). "The economic impact of chronic fatigue syndrome". Cost effectiveness and resource allocation : C/E. 2 (1): 4. doi:10.1186/1478-7547-2-4. PMC 449736. PMID 15210053.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  117. ^ Jason LA, Benton MC, Valentine L, Johnson A, Torres-Harding S; Benton; Valentine; Johnson; Torres-Harding (2008). "The Economic impact of ME/CFS: Individual and societal costs". Dyn Med. 7: 6. doi:10.1186/1476-5918-7-6. PMC 2324078. PMID 18397528.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  118. ^ Broderick G, Craddock TJ; Craddock (2013). "Systems biology of complex symptom profiles: Capturing interactivity across behavior, brain and immune regulation". Brain, Behavior, and Immunity. 29: 1–8. doi:10.1016/j.bbi.2012.09.008. PMC 3554865. PMID 23022717.
  119. ^ Van Houdenhove B, Neerinckx E, Onghena P, Vingerhoets A, Lysens R, Vertommen H; Neerinckx; Onghena; Vingerhoets; Lysens; Vertommen (2002). "Daily hassles reported by chronic fatigue syndrome and fibromyalgia patients in tertiary care: a controlled quantitative and qualitative study". Psychother Psychosom. 71 (4): 207–13. doi:10.1159/000063646. PMID 12097786.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  120. ^ Colby J (2007). "Special problems of children with myalgic encephalomyelitis/chronic fatigue syndrome and the enteroviral link". J Clin Pathol. 60 (2): 125–8. doi:10.1136/jcp.2006.042606. PMC 1860612. PMID 16935964. 16935964.
  121. ^ Prins JB, Bos E, Huibers MJ, Servaes P, van der Werf SP, van der Meer JW, Bleijenberg G; Bos; Huibers; Servaes; Van Der Werf; Van Der Meer; Bleijenberg (2004). "Social support and the persistence of complaints in chronic fatigue syndrome". Psychother Psychosom. 73 (3): 174–82. doi:10.1159/000076455. PMID 15031590.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  122. ^ Lee, Nancy. "Dr. Nancy Lee on International Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Awareness Day". U.S. Department of Health & Human Services. Retrieved 2013-10-12.
  123. ^ Poulton, Sonia (2012-05-08). "All in the mind? Why critics are wrong to deny the existence of chronic fatigue". Mail Online. Dail Mail. Retrieved 2014-02-07.
  124. ^ "'Torrent of abuse' hindering ME research". BBC. 2011-07-29. Retrieved 2011-07-31.
  125. ^ a b Wallace PG, Sharpe M (October 1991). "Post-viral fatigue syndrome. Epidemiology: a critical review" (PDF). Br Med Bull. 47 (4): 942–951. PMID 1794092.
  126. ^ a b c Mounstephen A, Sharpe M; Sharpe (1997). "Chronic fatigue syndrome and occupational health". Occupational Medicine. 47 (4): 217–27. doi:10.1093/occmed/47.4.217. PMID 9231495.
  127. ^ a b Hooge J (1992). "Chronic fatigue syndrome: cause, controversy and care". Br J Nurs. 1 (9): 440–1, 443, 445–6. PMID 1446147.
  128. ^ a b Sharpe M (1996). "Chronic fatigue syndrome". Psychiatr. Clin. North Am. 19 (3): 549–73. doi:10.1016/S0193-953X(05)70305-1. PMID 8856816.
  129. ^ Denz-Penhey H, Murdoch JC; Murdoch (1993). "General practitioners acceptance of the validity of chronic fatigue syndrome as a diagnosis". N. Z. Med. J. 106 (953): 122–4. PMID 8474729.
  130. ^ Greenlee JE, Rose JW; Rose (2000). "Controversies in neurological infectious diseases". Semin Neurol. 20 (3): 375–86. doi:10.1055/s-2000-9429. PMID 11051301.
  131. ^ Horton-Salway M (2007). "The ME Bandwagon and other labels: constructing the genuine case in talk about a controversial illness". Br J Soc Psychol. 46 (Pt 4): 895–914. doi:10.1348/014466607X173456. PMID 17535450.
  132. ^ Bowen, J; Pheby, D; Charlett, A; McNulty, C (August 2005). "Chronic Fatigue Syndrome: a survey of GPs' attitudes and knowledge". Family practice. 22 (4): 389–93. doi:10.1093/fampra/cmi019. PMID 15805128.
  133. ^ Anderson, JS; Ferrans, CE (June 1997). "The quality of life of persons with chronic fatigue syndrome". The Journal of Nervous and Mental Disease. 185 (6): 359–67. doi:10.1097/00005053-199706000-00001. PMID 9205421.
  134. ^ Larun, L; Malterud, K (December 2007). "Identity and coping experiences in Chronic Fatigue Syndrome: a synthesis of qualitative studies". Patient education and counseling. 69 (1–3): 20–8. doi:10.1016/j.pec.2007.06.008. PMID 17698311.
  135. ^ Dumit J (2005-08-08). "Illnesses you have to fight to get: facts as forces in uncertain, emergent illnesses". Soc Sci Med. Feb, 62 (3): 577–90. doi:10.1016/j.socscimed.2005.06.018. PMID 16085344.
  136. ^ "No blood from chronic fatigue donors: agency". CBC. 2010-04-07. Retrieved 2010-06-25.
  137. ^ Atkinson, K (2010-04-21). "Chronic Fatigue Set To Disqualify Blood Donors". Voxy.co.nz. Retrieved 2010-06-25.
  138. ^ "Blood Service updates CFS donor policy". Australian Red Cross Blood Service. Retrieved 2013-07-07.
  139. ^ "Recommendation on Chronic Fatigue Syndrome and Blood Donation". American Association of Blood Banks. 2010-06-18. Retrieved 2010-06-25.
  140. ^ a b NHS Blood and Transplant (2010-11-05). "ME/CFS sufferers permanently deferred from giving blood". Retrieved 2011-10-09. Cite error: The named reference "NHSBT" was defined multiple times with different content (see the help page).
  141. ^ Jason LA, Richman JA, Friedberg F, Wagner L, Taylor R, Jordan KM; Richman; Friedberg; Wagner; Taylor; Jordan (1997). "Politics, science, and the emergence of a new disease. The case of chronic fatigue syndrome". Am Psychol. 52 (9): 973–83. doi:10.1037/0003-066X.52.9.973. PMID 9301342.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  142. ^ Couper J (2000). "Chronic fatigue syndrome and Australian psychiatry: lessons from the UK experience". Aust N Z J Psychiatry. 34 (5): 762–9. doi:10.1046/j.1440-1614.2000.00810.x. PMID 11037362.
  143. ^ Hawkes, N. (22 June 2011). "Dangers of research into chronic fatigue syndrome". BMJ. 342 (jun22 1): d3780–d3780. doi:10.1136/bmj.d3780.
  144. ^ "Chronic fatigue syndrome researchers face death threats from militants". The Guardian. 2011-08-21. Retrieved 2015-08-25.
  145. ^ Whistler T, Unger ER, Nisenbaum R, Vernon SD; Unger; Nisenbaum; Vernon (December 2003). "Integration of gene expression, clinical, and epidemiologic data to characterize Chronic Fatigue Syndrome". J Transl Med. 1 (1): 10. doi:10.1186/1479-5876-1-10. PMC 305360. PMID 14641939.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  146. ^ Kennedy G, Abbot NC, Spence V, Underwood C, Belch JJ; Abbot; Spence; Underwood; Belch (February 2004). "The specificity of the CDC-1994 criteria for chronic fatigue syndrome: comparison of health status in three groups of patients who fulfill the criteria". Ann Epidemiol. 14 (2): 95–100. doi:10.1016/j.annepidem.2003.10.004. PMID 15018881.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  147. ^ Aslakson E, Vollmer-Conna U, White PD; Vollmer-Conna; White (April 2006). "The validity of an empirical delineation of heterogeneity in chronic unexplained fatigue". Pharmacogenomics. 7 (3): 365–73. doi:10.2217/14622416.7.3.365. PMID 16610947.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  148. ^ "Erythos.com" (PDF). Retrieved 2011-01-28.
  149. ^ "Chronic Fatigue Syndrome/Myalgic Encephalomyelitis". MRC.ac.uk. Retrieved 2011-01-28.
  150. ^ "APPGME.org.uk" (PDF). Retrieved 2011-01-28.

Further reading

External links


Retrieved from "https://en.wikipedia.org/w/index.php?title=Myalgic_encephalomyelitis/chronic_fatigue_syndrome&oldid=677977479"